Navigation Links
Cutting edge research into drug side effects could save NHS money and make more drugs safely available

Severe side effects account for one in sixteen NHS hospital admissions and take up four per cent of hospital bed capacity1. Many of these are preventable. Research to better understand drug side effects is now finding solutions that will prevent side effects derailing the development of new drugs, and avoid severe side effects from currently-available drugs.

Today, the MRC Centre for Drug Safety Science2 at the University of Liverpool is launching a public guide, Making Sense of Drug Safety Science3, in collaboration with the charity Sense About Science4. The guide explains why there is no such thing as a 'side effect free drug', and sets out how understanding more about side effects can help us tailor drugs to patients.

Drugs are currently withdrawn from use if there are reports of severe side effects5. This has already included painkillers, anti-diabetic and anti-HIV drugs. Although severe side effects are usually rare, if a drug is withdrawn because one person in 10,000 suffers, that means 9,999 people have to stop using a medicine that works. By first identifying which rare drug side effects can be predicted, researchers can develop tests that will tell doctors which patients can safely be given a drug.

Scientists at the MRC Centre for Drug Safety Science are developing predictive tests to identify those people who will suffer extreme drug side effects. These will also allow the drugs to be given safely to other patients.

  • Some tests developed in this way are already being used: The anti-HIV drug, abacavir, stopped being prescribed because it was linked to a small number of severe skin reactions. It was discovered that only patients with a specific genetic variant were susceptible, allowing drug safety researchers to develop a predictive genetic test. Now the severe rashes have been dramatically cut and abacavir continues to be used as an effective drug for the majority of patients.
  • Other tests are currently being developed based on recent scientific discoveries: Carbamazepine is a drug used to treat epilepsy and bipolar but a rare side effect of this medicine is a life-threatening skin condition, called Stevens Johnson Syndrome (SJS)6. Patients who developed SJS when taking this drug were identified to carry a specific genetic variant. Scientists are now evaluating whether this genetic variant can be used to predict whether patients are likely to develop SJS following carbamazepine therapy7.
  • Predictive tests are also used during drug development. Recent scientific advances from the study of drug-induced liver injury have led to the development of new experimental tools. These tools are being used to develop tests that can identify whether new candidate drugs have the potential to cause injury before they are tested in humans8.


Patricia Roberts who suffered from a disease caused by severe drug side effect: "When the symptoms started, I had no idea about Stevens-Johnson Syndrome and that it was caused by the drug I was taking. Although it is rare, it can be fatal in just a few hours so you need immediate treatment. I feel passionately that more people need to know about the enormity of this condition so they can get the right treatment quickly enough; but, most importantly, we need prevention."

***Patient case study is available in full from Sense About Science***

Professor Kevin Park, director of the MRC Centre for Drug Safety Science "Our research is increasing what we know about drug safety and helping us to give people better information about the risks associated with medicines. Improving our understanding of the mechanisms that lead to serious adverse side effects will lead to existing medicines being prescribed more safely and new medicines being developed more effectively. Through this guide we want to share with patients, GPs and other health professionals why drug safety science matters to everyone."

Emily Jesper, co-editor of the guide, Sense About Science: "Experiencing side effects is unpleasant, and not understanding them is frustrating. While it's impossible to have a drug with no side effects, we want to demystify why they happen and what can be done about them."

Martyn Lobley, GP and medical journalist: "Show me a drug with no side effects and I'll show you a drug with no benefits. When you take a medicine you're entering into a bargain. The prescriber, to the best of their knowledge, gives you a medicine that will do you more good than harm, but you have to accept the risk that it may do you more harm than good. For some medicines, we understand the risks and can mitigate them, but for others the knowledge is just not there yet."


Contact: Emily Jesper
SAGE Publications

Related medicine news :

1. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
2. More cutting-edge cancer research supported by industry
3. AGA presents cutting-edge research during DDW®
4. ASHA grant funds cutting-edge AIDS research at Tel Aviv University
5. New national clinical trials network for neurological disorders to foster cutting-edge treatments
6. Cutting-edge approaches to ensuring biologic drug quality focus of forum on bioassays
7. InnoVision and The Danse Team Up to Tell the Story of Cutting Edge Technology Through 3D Animation
8. Study: Curbing car travel could be as effective as cutting calories
9. InnoVative Capital Closes $41 Million FHA 242 Refinancing, Cutting Morehead Memorial Hospital's Loan Rate by 21% and Reducing Debt Service by $5 Million
10. Top Road Rage Triggers: Cutting In, Weaving
11. Director of the Center for Craniofacial & Dental Sleep Medicine Provides New Cutting Edge Technology for Patients Suffering with Obstructive Sleep Apnea
Post Your Comments:
(Date:1/27/2020)... ... January 27, 2020 , ... Controlled Contamination Services is ... the East/Central Regions. As Vice President of the East/Central Regions, she will be responsible ... has been with CCS since 2015 and has been an integral part of the ...
(Date:1/27/2020)... ... 2020 , ... ResMed Launches AirFit F30i, Its First Tube-up Full Face CPAP ... launch of the AirFit F30i, Its First Tube-up Full Face ResMed CPAP Mask. The ... tube-down connection, compact under-the-nose or traditional over-the-nose cushion styles, and even memory foam versus ...
(Date:1/24/2020)... ... January 24, 2020 , ... A new study ... Bellefonte Hospital (OLBH) achieved a 59 percent decrease in hospital onset CDI. This ... Disease Control and Prevention. , The retrospective pre-post [study recently published ...
(Date:1/24/2020)... (PRWEB) , ... January 24, 2020 , ... ... teaming up with celebrity fitness expert and best-selling nutrition author Jorge Cruise to ... and intermittent fasting. , “I’m an enthusiastic advocate of intermittent fasting, that is ...
(Date:1/23/2020)... ... January 23, 2020 , ... A January 7 article ... rid of them. The article quotes the president of the American Society of Plastic ... They can be caused by a person’s facial structure including an undefined jawline, a ...
Breaking Medicine News(10 mins):
(Date:1/24/2020)... NEW YORK (PRWEB) , ... January 24, 2020 , ... ... the U.S. to implement a systematic reform of the health care system. Recently, practicing ... Doherty, Senior Vice President of Governmental Affairs and Public Policy at ACP, teamed with ...
(Date:1/23/2020)... , ... January 23, 2020 , ... ... have trusted Australian Dream® for effective relief. Now, the company is ... , Australian Dream sought to develop a new design that better communicates the ...
(Date:1/23/2020)... ... January 23, 2020 , ... ... holds true for the complex architecture providing function to a person’s hand, wrist, ... – not just an orthopedic surgeon -- when anything goes wrong up or ...
Breaking Medicine Technology: