Navigation Links
Cutting Phosphate May Protect Kidney Patients From Heart Trouble
Date:4/23/2008

High levels are major source of cardiovascular death risk in those with chronic disease

WEDNESDAY, April 23 (HealthDay News) -- Readily available phosphate-binding drugs could help prevent heart disease in people with chronic kidney disease (CKD), a new study finds.

Researchers at Washington University School of Medicine in St. Louis noted that patients with chronic kidney disease (CKD) are at high risk of death from cardiovascular disease, and that recent studies have shown that a high level of phosphate in the blood is a major source of cardiovascular death risk in these patients.

In tests on mice with CKD, the researchers found that high blood phosphate levels directly stimulate calcification of blood vessels and that phosphate-binding drugs can decrease this vascular calcification. This means drugs that reduce phosphate levels may help protect CKD patients from cardiovascular disease, the researchers said.

The study was published in the Journal of the American Society of Nephrology.

"One of the kidney's functions is to help maintain a constant balance of phosphate in the bloodstream," senior author Dr. Keith A. Hruska, director of the Division of Pediatric Nephrology and professor of pediatrics, medicine and of cell biology and physiology, said in a prepared statement.

"When kidney failure occurs, an excess of serum phosphate develops. It turns out that high phosphate serves as a signal that stimulates cells within blood vessel walls to become bone-forming cells and to deposit calcium crystals. That produces vascular stiffness that is a cause of cardiovascular mortality," Hruska explained.

Based on the evidence from this and other studies, the U.S. Food and Drug Administration recently decided to extend the label of phosphate-binding drugs on the market. These drugs -- calcium acetate (PhosLo), sevelamer (Renagel) and lanthanum carbonate (Fosrenol) -- will now be labeled to indicate they are approved for treatment of high serum phosphate levels in CKD patients.

About 19 million Americans have chronic kidney disease.

Hruska and his colleagues also found that a growth factor called BMP-7 (bone morphogenic factor-7) reduced phosphate levels and calcification of blood vessels in mice with CKD.

"Elderly osteoporosis patients and people with diabetes have high rates of cardiovascular disease and high levels of vascular calcification. So, our findings may have importance even beyond patients with CKD," study co-author Dr. Suresh Mathew, an instructor in pediatrics, said in a prepared statement.

More information

The American Academy of Family Physicians has more about CKD.



-- Robert Preidt



SOURCE: Washington University School of Medicine in St. Louis, news release, April 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. RIVAs Cutting Edge Technology To Help Intermountain Healthcare Enhance Medication Delivery Safety
2. Billians HealthDATA(R) Continues to Delight Their Customers with Comprehensive Cutting Edge Healthcare Market Intelligence
3. Cutting Back on Salt Cuts Down on Sodas With Kids
4. Verizon teams with MCG to test cutting-edge technology
5. Cutting caffeine may help control diabetes
6. New Democracy Corps Battleground Poll of Swing Districts Finds Strong, Bi-Partisan Opposition to Cutting Medicare-Funded Nursing Home Care
7. FDA Mulls Cutting Salt in Processed Foods
8. Financial incentives may hold key to cutting child malaria deaths
9. Cutting Edge CyberKnife Cancer Treatment Center to Open in Tampa Bay Area
10. The era of global aging: GSA showcases cutting-edge San Francisco meeting topics
11. Fern Tree, The Spa at Half Moon, Jamaicas Premier Spa, Opens With Ceremonial Ribbon Cutting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ... two ostomy patients, standing as living proof that attitude and determination can combine ... and issues that spike around the holidays. This campaign will offer patients a ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is proud to ... which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that are helping ... prolonging life 6 years in the last 3 decades,” says Dr. Valentine Fuster, ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal Medical Systems, Inc. ... the first company to offer robotic imaging to veterinary medicine is sponsoring the ... 941 for the American Association of Equine Practitioners 62nd Annual Convention from December ...
(Date:12/2/2016)... ... ... Yisrayl Hawkins, at The House of Yahweh in Abilene, Texas, has published ... Yisrayl says this generation, known as the Last Generation, started in 1934 A.Y. (After ... up exactly with Bible Prophecy – a protected way for those who will believe. ...
(Date:12/2/2016)... ... December 02, 2016 , ... On ... individuals and families from eight different sites throughout Miami-Dade and Broward counties. This ... volunteers worked very hard on Thanksgiving morning by putting together individual meals via ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... National Pharmacy Services, LLC ("Maxor"), today announced that it has ... of Texas -based Maxor Specialty / IV ... both company,s clinical expertise and high-touch patient service models to ... About Maxor ... , , Established ...
(Date:12/2/2016)... , Dec. 2, 2016 Boston Scientific Corporation ... agreement to acquire certain manufacturing assets and capabilities of ... NVC) advanced biological tissue business, as well as a ... $75 million in cash. The Neovasc advanced biological tissue ... the Boston Scientific Lotus™ Valve System. * Upon ...
(Date:12/2/2016)... N.J. , Dec. 2, 2016   CytoSorbents ... immunotherapy leader commercializing its European Union approved CytoSorb ... and cardiac surgery patients worldwide, announced that Dr. ... the 9th Annual LD Micro Main Event ... , 2016 at the Luxe Sunset Boulevard Hotel in ...
Breaking Medicine Technology: