Navigation Links
Current and former smokers at risk for recurrent hepatitis post-liver transplantation

Transplant recipients who smoke or have smoked increase their risk of viral hepatitis reinfection following liver transplantation according to new research available in the July issue of Liver Transplantation, a journal published by Wiley on behalf of American Association for the Study of Liver Diseases. Findings suggest that tobacco in cigarettes may adversely affect immune system response in patients transplanted for viral hepatitis.

According to the Centers for Disease Control and Prevention (CDC), tobacco use causes more than five million deaths per year worldwide, with estimates suggesting that annual mortality rates could climb to more than eight million by 2030. Previous research reports that nearly 34% of liver transplant recipients are active or former tobacco users. Moreover, medical evidence has shown that smoking increased biliary and vascular complications in the short-term, and elevated risk of all-cause, cardiovascular and sepsis-related mortality in the long-term among those receiving livers.

"Organs available for transplantation are scarce, with livers particularly in short supply," explains Dr. Mamatha Bhat from McGill University in Canada. "Transplant centers need to take an active role in identifying and minimizing risks to the success of liver transplantation." In the present study, researchers assessed the impact of smoking on incidence of complications, such as recurrent viral hepatitis, following liver transplantation.

Analysis of demographic characteristics and post-transplantation complications was performed on data from primary liver transplant recipients over a 14-year period. Using data from the McGill University Health Centre (MUHC) Liver Transplant database, the team identified 444 patients who received liver transplants between 1990 and 2004, of which 63 were repeat transplants. The mean age of liver recipients was 55 years and 66% were male with a mean body mass index (BMI) of 27.

Results show that 23% of transplant recipients were active or ex-smokers and 78% were non-smokers. Of those who ever smoked, 78% were male and 88% were Caucasian. The cause of liver disease was likely to be alcohol related in 29% of smokers or ex-smokers compared to 16% non-smokers. Researchers estimated the median survival time for smokers following transplantation was just over 13 years.

Further analysis shows that the recurrent viral hepatitis-free survival time was less than one year for smokers and close to five years for non-smokers. The team found that patient survival, and time to biliary complications, first rejection and depression post-transplantation was not linked to smoking status. However, recurrent viral hepatitis-free survival was strongly associated with smoking.

"Our findings suggest that recurrence of viral hepatitis may be more frequent among liver transplant recipients who are active or former smokers," concludes Dr. Bhat. "Encouraging preoperative smoking cessation may be beneficial in improving patient outcomes following transplantation." The authors stress that their findings do not suggest the denial of liver transplantation, but that transplant specialists be more vigilant in monitoring for complications in those candidates who continue to smoke. They call for validation of their results in larger studies that examine the effects of smoking and other potential modifiable risks.

Contact: Dawn Peters

Related medicine news :

1. Why current strategies for fighting obesity are not working
2. Triple negative breast cancer symposium highlights current advances
3. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
4. New coral reef crustacean described and named after late reggae performer Bob Marley
5. Researchers offer new approach to track former prisoners access to community HIV care
6. Special Needs Spotlight: Former SFMTA Board Member Bruce Oka Receives Treatment with San Francisco Sedation Dentist Dr. David Blende
7. Former Athlete Credits Sports for Surviving Horrible Car Accident and Lengthy Coma
8. Former Vikings and NFL Greats Tackle Sleep Apnea at Upcoming Minneapolis Event
9. New Electronic Cigarette Free Trial Kit Adds More Years to Smokers Life by Making it Easy to Quit Smoking
10. A better way to help high-risk pregnant smokers
11. Graphic Cig Pack Labels Make Smokers Think, Study Finds
Post Your Comments:
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
Breaking Medicine Technology: