Navigation Links
Current HPV vaccine may not help some women with immune problems
Date:4/7/2013

WASHINGTON, DC (April 7, 2013)Women with HIV acquire cancer-causing forms of the human papillomavirus (HPV) that are not included in the current HPV vaccines Gardasil and Cervarix, according to new research from Fox Chase Cancer Center being presented at the AACR Annual Meeting 2013 on Sunday, April 7.

"People with issues in their immune system such as HIV will be at risk of acquiring HPV, as well and the current vaccine may not fully protect them," says study author Elizabeth Blackman, MPH, research specialist at Fox Chase.

Women who had been taking HIV medications for at least 4 years, however, were less likely to carry cancer-causing forms of HPV, suggesting that treating HIV may also protect women from the consequences of HPV. "Protecting the immune system may prevent other diseases," says Blackman.

More than 40 types of HPV can infect the genital areas and at least 15 of these types are considered "high risk," meaning they can cause changes in cells that can lead to cancer. In the U.S., approximately 4,000 women die each year from cervical cancer, which almost always stems from HPV infection.

But HPV is very commonpractically every sexually active person will acquire it at some point. In most cases, these infections do not lead to cancer, says Blackman, because a healthy immune system can normally clear the virus on its own. "But if your immune system is compromised, such as in HIV, you will not be able to fight off the infection," she says. "Over time, persistent infection with HPV can lead to cancer."

During the study, Blackman and her colleagues tested 176 HIV-positive women living in the Bahamas for the presence of high risk forms of HPV. They chose this population, she explains, because different strains of HPV are prominent in different geographic regions.

Around three-quarters of the women tested carried high-risk forms of HPV and approximately 30% had precancerous cervical cells, as well. The current vaccines for HPV prevent infections from 16, and 18, the most common types attributed to 70% of all cervical cancer world-wide. But Blackman and her colleagues found that many HIV-positive women living in the Bahamas who had precancerous cervical cells carried HPV types 16 and 18 but also had prominent infections with HPV types 52 and 58, which are high-risk but not protected by the current vaccines.

Previous research has also shown that other populations of women with immune system problems can acquire atypical cancer-causing forms of HPV, says Blackman.

Women who had been taking highly active retroviral therapy (HAART) to treat their HIV for at least 4 years were less likely to have high-risk forms of HPV, suggesting that controlling the immune system may curb additional infections. "If women take medications for a long enough time, their immune system may prevent other diseases from developing," Blackman suggests.


'/>"/>

Contact: Diana Quattrone
diana.quattrone@fccc.edu
215-815-7828
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Global burden of dengue is triple current estimates
2. d'Oliveira & Associates Issues New Infographic on Xarelto Providing Current FDA and Medical Study Information
3. Current and past smokers face greater risk for hip replacement failure
4. About 15 percent of patients with Wolfram syndrome do not meet current diagnostic criteria
5. Lung Cancer Asbestos Victims Center Now Urges Current Lung Cancer Victims Who Were Exposed to Asbestos at Work to Call Them About What Might be Significant Compensation
6. 5-ALA fluorescence guides resection of recurrent glioblastoma multiforme
7. d’Oliveira & Associates Issues Webpage With Current Information On Mirena IUD Lawsuits
8. Rooting out recurrent breast cancer
9. Study drug is first to help patients with recurrent low-grade ovarian cancer
10. Tomorrows life-saving medications may currently be living at the bottom of the sea
11. d’Oliveira & Associates Releases Webpage With Current Information on Fresenius Lawsuits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... April 26, 2017 , ... The National Business ... National Registry of Emergency Medical Technicians and welcomes this organization to ... Dr. Jan G. West, Ph.D. , CEO & Organizational Psychologist at NBRI. “This ...
(Date:4/26/2017)... ... April 26, 2017 , ... Want to ... website ( CRISPRCas.pioneer.com ) that demonstrates how this advanced plant breeding technology is ... better food, with fewer resources. It highlights the business’ principles, research and collaboration ...
(Date:4/25/2017)... ... 25, 2017 , ... Bellus Medical, a leader in medical ... new class of photodynamic cosmetics (PDC). , Allumera® is the first PDC cream ... of aging, and minimize the appearance of pores – all with minimal downtime ...
(Date:4/25/2017)... ... April 25, 2017 , ... A stressful work environment can ... also decrease overall productivity and performance in the workplace. The goal of Clearview Resolution ... last few weeks of April, Clearview Resolution Services will be shutting down the office ...
(Date:4/25/2017)... Lutz, FL (PRWEB) , ... April 25, 2017 , ... ... transform their smiles by using Invisalign® in Lutz, FL. With the help ... oral health and aesthetics with fewer potential complications, more discretion and less pain. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... CRH) (NYSE MKT: CRHM) (the "Company"), announces that it will participate ... the Sheraton Hotel in Toronto, Ontario . ... is scheduled to present on Tuesday, May 2 at 10:00 am. ... the Board, Tony Holler will also attend the event. ... For more details about the ...
(Date:4/19/2017)... Global Surgical Drainage Device Market: Overview ... remove excess liquid and air. The fluid to be ... lymph. Surgical drains are used in a wide variety ... cardiovascular surgery, neurosurgery, plastic surgery etc. Common use of ... of fluid e.g. blood or pus. Surgical drains are ...
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
Breaking Medicine Technology: