Navigation Links
Current HPV vaccine may not help some women with immune problems

WASHINGTON, DC (April 7, 2013)Women with HIV acquire cancer-causing forms of the human papillomavirus (HPV) that are not included in the current HPV vaccines Gardasil and Cervarix, according to new research from Fox Chase Cancer Center being presented at the AACR Annual Meeting 2013 on Sunday, April 7.

"People with issues in their immune system such as HIV will be at risk of acquiring HPV, as well and the current vaccine may not fully protect them," says study author Elizabeth Blackman, MPH, research specialist at Fox Chase.

Women who had been taking HIV medications for at least 4 years, however, were less likely to carry cancer-causing forms of HPV, suggesting that treating HIV may also protect women from the consequences of HPV. "Protecting the immune system may prevent other diseases," says Blackman.

More than 40 types of HPV can infect the genital areas and at least 15 of these types are considered "high risk," meaning they can cause changes in cells that can lead to cancer. In the U.S., approximately 4,000 women die each year from cervical cancer, which almost always stems from HPV infection.

But HPV is very commonpractically every sexually active person will acquire it at some point. In most cases, these infections do not lead to cancer, says Blackman, because a healthy immune system can normally clear the virus on its own. "But if your immune system is compromised, such as in HIV, you will not be able to fight off the infection," she says. "Over time, persistent infection with HPV can lead to cancer."

During the study, Blackman and her colleagues tested 176 HIV-positive women living in the Bahamas for the presence of high risk forms of HPV. They chose this population, she explains, because different strains of HPV are prominent in different geographic regions.

Around three-quarters of the women tested carried high-risk forms of HPV and approximately 30% had precancerous cervical cells, as well. The current vaccines for HPV prevent infections from 16, and 18, the most common types attributed to 70% of all cervical cancer world-wide. But Blackman and her colleagues found that many HIV-positive women living in the Bahamas who had precancerous cervical cells carried HPV types 16 and 18 but also had prominent infections with HPV types 52 and 58, which are high-risk but not protected by the current vaccines.

Previous research has also shown that other populations of women with immune system problems can acquire atypical cancer-causing forms of HPV, says Blackman.

Women who had been taking highly active retroviral therapy (HAART) to treat their HIV for at least 4 years were less likely to have high-risk forms of HPV, suggesting that controlling the immune system may curb additional infections. "If women take medications for a long enough time, their immune system may prevent other diseases from developing," Blackman suggests.


Contact: Diana Quattrone
Fox Chase Cancer Center

Related medicine news :

1. Global burden of dengue is triple current estimates
2. d'Oliveira & Associates Issues New Infographic on Xarelto Providing Current FDA and Medical Study Information
3. Current and past smokers face greater risk for hip replacement failure
4. About 15 percent of patients with Wolfram syndrome do not meet current diagnostic criteria
5. Lung Cancer Asbestos Victims Center Now Urges Current Lung Cancer Victims Who Were Exposed to Asbestos at Work to Call Them About What Might be Significant Compensation
6. 5-ALA fluorescence guides resection of recurrent glioblastoma multiforme
7. d’Oliveira & Associates Issues Webpage With Current Information On Mirena IUD Lawsuits
8. Rooting out recurrent breast cancer
9. Study drug is first to help patients with recurrent low-grade ovarian cancer
10. Tomorrows life-saving medications may currently be living at the bottom of the sea
11. d’Oliveira & Associates Releases Webpage With Current Information on Fresenius Lawsuits
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert ... Organizations, One Beat ” campaign. The partnership between the two groups began in 2014 ... MAP International’s cause. , MAP International was founded in 1954 and is an international ...
(Date:11/25/2015)... ... ... On November 25, 2015, officials of Narconon Arrowhead , the drug rehabilitation ... new cutting edge recovery program that has been 50 years in the making. ... with the purpose to free addicts from the symptoms and negative behaviors of addiction. ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study conducted by an ... IL, UV Angel is evaluating the efficacy of its product and its disinfection protocol. ... 30 beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical ...
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
(Date:11/25/2015)...  Today AVACEN Medical announced the issue of United States patent No. ... ". This patent shields the company,s AVACEN 100 dry heat therapy medical device and specific methods ... Photo - ... ... ...
(Date:11/25/2015)... , Nov. 25, 2015 USP 800 ... drug preparations (e.g. pharmacists, pharmacy technicians, nurses, physicians, ... technicians). The chapter also covers all entities which ... pharmacies, hospitals, other healthcare institutions, patient treatment clinics, ... --> --> What is ...
Breaking Medicine Technology: