Navigation Links
Curcumin shows promise in attacking Parkinson's disease
Date:3/20/2012

EAST LANSING, Mich. Curcumin, a compound found in the spice turmeric, is proving effective at preventing clumping of a protein involved in Parkinson's disease, says a Michigan State University researcher.

A team of researchers led by Basir Ahmad, an MSU postdoctoral researcher, demonstrated earlier this year that slow-wriggling alpha-synuclein proteins are the cause of clumping, or aggregation, which is the first step of diseases such as Parkinson's. A new study led by Ahmad, which appears in the current issue of the Journal of Biological Chemistry, shows that curcumin can help prevent clumping.

"Our research shows that curcumin can rescue proteins from aggregation, the first steps of many debilitating diseases," said Lisa Lapidus, MSU associate professor of physics and astronomy who co-authored the paper with Ahmad. "More specifically, curcumin binds strongly to alpha-synuclein and prevents aggregation at body temperatures."

Lapidus' lab uses lasers to study protein folding. Proteins are chains of amino acids that do most of the work in cells. Scientists understand protein structure, but they don't know how they are built a process known as folding. Lapidus' team is shedding light on the process by correlating the speed at which protein folds with its tendency to clump or bind with other proteins.

When curcumin attaches to alpha-synuclein it not only stops clumping, but it also raises the protein's folding or reconfiguration rate. By bumping up the speed, curcumin moves the protein out of a dangerous speed zone allowing it to avoid clumping with other proteins.

Finding a compound that can fix a protein when it first begins to misfold can lead scientists to identify drugs that can treat certain diseases. Doctors won't be prescribing curcumin pills any time soon, though, Lapidus said.

"Curcumin's usefulness as an actual drug may be pretty limited since it doesn't go into the brain easily where this misfolding is taking place," she said. "But this kind of study showcases the technique of measuring reconfiguration and opens the door for developing drug treatments."


'/>"/>

Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Related medicine news :

1. Curcumin compound improves effectiveness of head and neck cancer treatment, U-M study finds
2. Curcumin nanoparticles open up resistant cancers
3. Newborn screening for DMD shows promise as an international model
4. Mothers of Kids With Autism Earn Less, Study Shows
5. Study shows air emissions near fracking sites may impact health
6. Half of Stroke Victims Dont Call 911, Research Shows
7. Largest ever study of childhood ALL shows improving survival
8. New study shows promise for developing new treatments for breast cancer
9. HIV/AIDS vaccine shows long-term protection against multiple exposures in non-human primates
10. NEJM study shows combination treatments benefit melanoma patient
11. Experimental Drug Shows Promise Against Cushings Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... NJ (PRWEB) , ... May 31, 2016 , ... Dr. ... Medicine and Dentistry of New Jersey in the class of 1986, where he graduated ... cosmetic dentistry at his current location in Livingston since 1989. He has been a ...
(Date:5/31/2016)... ... 2016 , ... CURE Media Group , the nation’s ... Cancer and Careers to its Advocacy Spotlight Partnership program ... careers while fighting cancer. , As partners, both organizations will supply timely information ...
(Date:5/30/2016)... ... May 30, 2016 , ... ... inside of FCPX," said Christina Austin - CEO of Pixel Film Studios. ... within Final Cut Pro X. Choose from abstract transitions to more simple wipes ...
(Date:5/30/2016)... ... ... Another ER facility operated by First Choice Emergency Room opened ... and is open 24 hours daily. , First Choice Emergency Room hosted a ribbon ... Jasper High School band entertained attendees and accepted First Choice Emergency Room’s donation on ...
(Date:5/29/2016)... ... , ... "With 30 unique self-animating web themed intros and complete control over ... said Christina Austin - CEO of Pixel Film Studios. , ProIntro Web Volume ... Final Cut Pro X. Pixel Film Studios’ minimalistic titles allow users to add a ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... BANGALORE , May 30, 2016 - ... Limb Ischemia due to Buerger,s disease - Stempeucel® becomes ... body, anywhere in the world - Buerger,s Disease (also ... India and Globally - Prevalence ... India and 2 per 10,000 persons in the European ...
(Date:5/27/2016)... 27, 2016  A new study highlights the necessity of health literacy within the ... the American College of Radiology , a majority of oncology patients undergo imaging screenings ... http://photos.prnewswire.com/prnh/20160527/373022 ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... -- Hutchison China MediTech (Chi-Med) (HCM) ... highly lucrative global oncology and immunology markets. HCM ... or best-in-class tyrosine kinase inhibitor (TKI) drugs, some ... HCM,s profitable Chinese healthcare business continues to benefit ... of the mid-to-late-stage pipeline during 2016-17 (including US ...
Breaking Medicine Technology: