Navigation Links
Curcumin compound improves effectiveness of head and neck cancer treatment, U-M study finds
Date:5/19/2011

ANN ARBOR, Mich. A primary reason that head and neck cancer treatments fail is the tumor cells become resistant to chemotherapy drugs. Now, researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from the Indian spice curcumin can help cells overcome that resistance.

When researchers added a curcumin-based compound, called FLLL32, to head and neck cancer cell lines, they were able to cut the dose of the chemotherapy drug cisplatin by four while still killing tumor cells equally as well as the higher dose of cisplatin without FLLL32.

The study appears this week in the Archives of Otolaryngology Head and Neck Surgery.

"This work opens the possibility of using lower, less toxic doses of cisplatin to achieve an equivalent or enhanced tumor kill. Typically, when cells become resistant to cisplatin, we have to give increasingly higher doses. But this drug is so toxic that patients who survive treatment often experience long-term side effects from the treatment," says senior study author Thomas Carey, Ph.D., professor of otolaryngology and pharmacology at the U-M Medical School and co-director of the Head and Neck Oncology Program at the U-M Comprehensive Cancer Center.

That tumors become resistant to cisplatin is a major reason why head and neck cancer patients frequently see their cancer return or spread. It also plays a big role in why five-year survival for head and neck cancer has not improved in the past three decades.

FLLL32 is designed to sensitize cancer cells at a molecular level to the antitumor effects of cisplatin. It targets a key type of protein called STAT3 that is seen at high levels in about 82 percent of head and neck cancers. High levels of STAT3 are linked to problems with normal cell death processes, which allow cancer cells to survive chemotherapy treatment. STAT3 activation has been associated with cisplatin resistance in head and neck cancer.

Curcumin is known to inhibit STAT3 function, but it is not well-absorbed by the body. FLLL32 was developed by researchers at Ohio State University to be more amenable to use in people. The current study used the compound only in cell lines in the laboratory.

In the current study, researchers compared varying doses of cisplatin alone with varying doses of cisplatin plus FLLL32 against two sets of head and neck cancer cells: one line that was sensitive to cisplatin and one line that was resistant.

They found that FLLL32 decreased the activation levels of STAT3, sensitizing both resistant and sensitive tumor cells to cisplatin. Further, lower doses of cisplatin with FLLL32 were equally effective at killing cancer cells as the higher doses of cisplatin alone.

Separate studies suggest FLLL32 may not be well-absorbed by the body and researchers are developing a next generation compound that they hope improves on that. The U-M team plans to further study this newer compound for its potential as part of head and neck cancer treatment. Clinical trials using this compound are not currently available.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. Curcumin nanoparticles open up resistant cancers
2. Compound shows promise against intractable heart failure
3. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
4. Chemotherapy plus synthetic compound provides potent anti-tumor effect in pancreatic cancers
5. New pyrimidine compounds may lead to improved treatments for childhood brain cancer
6. Researchers find compound effective in destroying antibiotic-resistant biofilms
7. Compound enhances cancer-killing properties of agent in trials
8. Concentration, timing and interactions are key when it comes to dietary compounds
9. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
10. Plant compound resveratrol shown to suppresses inflammation, free radicals in humans
11. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Curcumin compound improves effectiveness of head and neck cancer treatment, U-M study finds
(Date:5/4/2016)... ... 04, 2016 , ... IsoComforter, Inc., one of the Nations ... newly improved Iso-Hip Wrap. The newly designed hip wrap has been specifically ... enables the patient to enjoy the benefits of cold therapy while resting, sitting, ...
(Date:5/4/2016)... ... May 04, 2016 , ... A new collaboration will give ... Duke Clinical Research Institute (DCRI) and analytics leader SAS will provide researchers worldwide with ... by the Duke University Health System. , The DCRI and SAS share the ...
(Date:5/4/2016)... ... May 04, 2016 , ... Slepkow Slepkow & ... one of the top website design companies to create a state of the ... to the law firm's main practice areas. These practice areas include: real estate, ...
(Date:5/4/2016)... , ... May 04, 2016 , ... Francesca Loparco, Co-Founder ... her life forever with a same-day LASIK procedure at Christenbury Eye Center. ... Dr. Jonathan Christenbury performed her surgery the same day as her in-office consultation and ...
(Date:5/4/2016)... CA (PRWEB) , ... May 04, 2016 , ... Advanced ... technology to help restore its patients’ health, is hosting a free seminar on stem ... will be held at Advanced Spine & Sport, 4601 Telephone Road, Suite 110, Ventura, ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 4, 2016 According to a ... Computer Interface Market - Global Industry Analysis, Size, Share, ... computer interface (BCI) market  is expected to reach a ... estimated to expand at a CAGR of 14.9 % ... A BCI device provides collaboration between the brain ...
(Date:5/4/2016)... upgrade. There are many medical recorders on the market but none like this. Through ...  offers unparalleled connectivity and functionality.  Ampronix  is a renowned authorized reseller of the medical ... Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
(Date:5/4/2016)... ZIONA, Israel , May 4, 2016 /PRNewswire/ ... announced today that BiondVax,s CEO, Dr. Ron Babecoff , ... New York City . On ... at Pioneers 2016, a conference presented by Joseph Gunner ... Hotel. The BiondVax presentation that Dr. Babecoff will ...
Breaking Medicine Technology: