Navigation Links
Cultured CTCs reveal genetic profile, potential drug susceptibility of breast cancer cells
Date:7/10/2014

Circulating tumor cells captured with a microchip-based device developed at the Massachusetts General Hospital (MGH) Center for Engineering in Medicine and the MGH Cancer Center can be cultured to establish cell lines for genetic analysis and drug testing. In the July 11 issue of Science, an MGH research team reports that the cultured cells accurately reflect a tumor's genetic mutation over time and changing susceptibility to therapeutic drugs.

"We now can culture cells from the blood that represent those present in metastatic deposits, which allows testing for drug susceptibility as the tumor evolves and acquires new mutations," says Shyamala Maheswaran, PhD, of the MGH Cancer Center, co-senior author of the Science paper. "We need to improve culture techniques before this is ready for clinical use, and we are working on doing that right now."

Circulating tumor cells (CTCs) are living solid-tumor cells that break off from either a primary or metastatic tumor and are carried through the bloodstream in extremely small quantities. The current version of the MGH-developed device, called the CTC-iChip, does not rely on prior identification of marker proteins on the surface of tumor cells, a limitation of previous versions of the MGH device and of the only commercially available device for capturing CTCs. Cell-surface proteins can change as tumors mutate during metastasis or in response to treatment, raising the possibility that methods targeting specific proteins may not reveal the full spectrum of CTCs.

The current study was designed to verify the ability of the CTC-iChip first described in an April 2013 Science Translational Medicine report to capture viable CTCs in a way that enables the establishment of cell lines that accurately represent the genetic status of all existing tumor sites and can be used for the testing of therapeutic drugs. The researchers first isolated CTCs from the blood of 36 patients with met
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Benefits of Cultured Vegetables and Probiotics for Immune Health Published by in new Article eProbiotics.com
2. Study reveals protective role for specialized cells in intestinal and respiratory systems
3. Infant toenails reveal in utero exposure to low-level arsenic, Dartmouth study finds
4. New study reveals how tumors remodel their surroundings to grow
5. Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
6. Unsuspected aspect of immune regulation revealed
7. Nanoscale ruler reveals organization of the cell membrane
8. Survey reveals consumers pecan preferences
9. Penn study reveals a common genetic link in fatal autoimmune skin disease
10. Seemingly invincible cancers stem cells reveal a weakness
11. First survey of ACOs reveals surprising level of physician leadership
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Sound Telecom, a leader in the call center industry, just ... they wonder, “Should I use an answering service?” The graphic ... a series of yes or no questions that ultimately ends ... many considerations and scenarios that come into play when deciding ... This decision infographic serves as a bit of a map ...
(Date:10/30/2014)... -- Scientists who used stem cells to create miniature ... provide a new way to learn more about the ... used human pluripotent stem cells -- which can become ... grow the functional miniature stomachs, to study infection by ... ulcers and stomach cancer. The miniature stomachs offer ...
(Date:10/30/2014)... Thompson HealthDay Reporter WEDNESDAY, ... could be bad for your health, a new study reports. ... can help strengthen bones and prevent osteoporosis. These benefits to ... as part of a healthy diet. But this new ... protect men or women from bone fractures, and was linked ...
(Date:10/30/2014)... WEDNESDAY, Oct. 29, 2014 (HealthDay News) -- Eating a ... difficult to treat, according to new research. ... or modified Atkins diet, that focuses on foods like ... could help reduce seizures in adults whose condition doesn,t ... the 35 percent of people with epilepsy whose seizures ...
(Date:10/30/2014)... -- A new vaccine that could help prevent some ... the U.S. Food and Drug Administration on Wednesday. ... of 10 and 25 from invasive meningococcal disease caused ... The bacteria can infect the bloodstream (sepsis) and the ... is a leading cause of bacterial meningitis, and infection ...
Breaking Medicine News(10 mins):Health News:Sound Telecom Produces Decision Infographic to Aid Businesses 2Health News:Is Milk Your Friend or Foe? 2Health News:Is Milk Your Friend or Foe? 3Health News:High-Fat, Low-Carb Diet May Help With Tough-to-Treat Epilepsy 2Health News:High-Fat, Low-Carb Diet May Help With Tough-to-Treat Epilepsy 3Health News:FDA Approves New Vaccine to Protect Against Meningitis 2
... Sri Ravishankar has said practising yoga, pranayam and meditation will ... // ,'Youths crave for something different and it ... to them,' he said while interacting with reporters last evening ... km from here., ,Ravi Shankar appealed to the youths ...
... to the researchers at the Harvard Medical School it is ... of chronically infected cystic fibrosis (CF) patients. // Pseudomonas aeruginosa ... in the CF patients says Joseph Mougous, lead author of ... ‘In the case of Pseudomonas aeruginosa, the host may be ...
... became orphaned after their HIV-infected parents died four years ... at a function here tomorrow.// ,The function, ... care of the children's health, education and welfare, would ... K Sreemati, who at a recent Cabinet meeting mooted ...
... and lung cancer has now been found to cause ... Institute of Medicine revealed this finding in its report. ... but not sufficient’ evidence to point out conclude mineral ... cancer. However there was insufficient evidence to relate asbestos ...
... A new US government report has found that risky health ... rash motor vehicle driving are declining among the American youth ... trend needs to be steeper and the disparities between racial ... ,As director of the division of adolescent and school health ...
... at the Johns Hopkins Bloomberg School of Public Health ... ward off bacterial// pathogens and plasmodium parasites. The study ... proteins in the immune system of mosquitoes. ... limiting infection by the malaria parasites were also important ...
Cached Medicine News:Health News:Treatment of Bacterial Infection Paves the Way to Treat CF Infection 2Health News:Laryngeal Cancer Added to Asbestos’ Crime Lis 2Health News:US Teens turn Wiser to Risky Behavior 2Health News:US Teens turn Wiser to Risky Behavior 3Health News:What Ticks the Mosquito immune system? 2
(Date:10/30/2014)... LOS ANGELES , Oct. 29, 2014 /PRNewswire/ ... pharmaceutical company devoted to bringing new products to ... 2015. ViaDerma has developed an innovative, ... for rapid mass transfer of pharmaceutical active ingredients ... to provide immediate localized therapy. The transdermal delivery ...
(Date:10/30/2014)... Oct. 30, 2014 Today Eli Lilly and ... its long-standing technology transfer program to increase the global ... 2003, the effort included Lilly donating manufacturing technology and ... China , India , ... Africa – all MDR-TB ,hot spots., It ...
(Date:10/27/2014)... , Oct. 27, 2014  Demonstrations by ... devices are being featured this week in ... Scientific Assembly where more than 7,000 emergency physicians ... and participating in educational courses. These ... drop of true-to-life emergency department environments, including three ...
Breaking Medicine Technology:ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3Lilly Shares Insights from Decade-Long Technology Transfer Experience 2Lilly Shares Insights from Decade-Long Technology Transfer Experience 3Lilly Shares Insights from Decade-Long Technology Transfer Experience 4Emergency Medicine of the Future Demonstrated at ACEP14 2Emergency Medicine of the Future Demonstrated at ACEP14 3Emergency Medicine of the Future Demonstrated at ACEP14 4Emergency Medicine of the Future Demonstrated at ACEP14 5Emergency Medicine of the Future Demonstrated at ACEP14 6Emergency Medicine of the Future Demonstrated at ACEP14 7Emergency Medicine of the Future Demonstrated at ACEP14 8Emergency Medicine of the Future Demonstrated at ACEP14 9Emergency Medicine of the Future Demonstrated at ACEP14 10Emergency Medicine of the Future Demonstrated at ACEP14 11Emergency Medicine of the Future Demonstrated at ACEP14 12Emergency Medicine of the Future Demonstrated at ACEP14 13Emergency Medicine of the Future Demonstrated at ACEP14 14Emergency Medicine of the Future Demonstrated at ACEP14 15
Pipetman P is a fully adjustable, air-displacement pipette with the selected volume shown on a digital indicator (volumeter). Eight models cover the full range of volumes from 0.2 L to 10 mL....
... Since 1991 Intersurgical Incorporated ... filters, heat and moisture ... therapy products, hand-held nebulizers ... of accessories and connectors ...
Research Series 2100 Adjustable-volume Pipette, 2.0-20 l, single-channel with adjustable-volume setting...
The Leader in ICU Humidification., ,Available Configurations: , Gas Sampling Port, Straight Flex Tube, Poppel Flex Tube, Luer Port for Pressure, Monitoring/Secretion Removal, Special Use Devices, M...
Medicine Products: