Navigation Links
Crystallography reveals the 3-D structure of mammalian sperm receptor
Date:12/4/2008

Scientists at the Swedish medical university Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for the interaction between the mammalian egg coat and sperm. The findings, presented in Nature, gives a first glimpse into the molecular architecture of animal egg coats, with important implications for the future of human reproductive medicine and the possibility of developing novel contraceptives.

The beginning of every new life starts with fertilization, the most crucial step of which is the initial species-specific recognition between egg and sperm. The receptors for sperm, proteins ZP3 and ZP2, contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein Crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N domain.

"ZP3 was identified almost 30 years ago, but obtaining structural information on this key reproductive protein has been technically challenging due to its high heterogeneity", says Luca Jovine.

The zona pellucida is essential for natural fertilization in mammals. The Karolinska Institutet researchers hope that X-ray crystallographic characterization of a region of ZP3 that is important for its ability to polymerize could help explaining cases of human infertility, as well as lead to the development of novel targeted, non-hormonal contraceptives. The research made on the ZP-N domain has also provided insights that extend beyond the field of reproduction. Among other things, an unexpected parallel has been uncovered with molecular features that are involved in speciation among invertebrates.

Moreover, ZP-N domains are also found in many other extracellular proteins that are unrelated to fertilization, but play important roles in human diseases such as non-syndromic deafness, renal and vascular disorders, and cancer. In the Nature paper, an example is discussed that shows how the structure of ZP-N can be used to understand the molecular basis of some of these disorders.

"Mammalian fertilization involves a highly complex series of events. Our findings pave the way for future investigations into this fascinating subject by providing a first snapshot of the beginning of life at atomic resolution", says Luca Jovine.


'/>"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. Survey reveals disparities in skin cancer knowledge, protection among high school students
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. Inc. Magazine Reveals Its 26th Annual List of Americas 500 Fastest-Growing Private Companies
5. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
6. New Survey Reveals Kidney Patients Concern About Medicare Policies
7. UCSD study reveals the regulatory mechanism of key enzyme
8. UCSD study reveals the regulatory mechanism of key enzyme
9. Poll reveals public awareness of nanotech stuck at low level
10. Survey reveals ignorance and confusion about cancer amongst the elderly
11. Story Reveals How Isabel and Her Family Learn About Bone Health and Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... TherapySites, the leading website and ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to extend ... exclusive benefits and promotional offers. , "TCA is extremely excited about this new ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: