Navigation Links
Crystallography reveals the 3-D structure of mammalian sperm receptor
Date:12/4/2008

Scientists at the Swedish medical university Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for the interaction between the mammalian egg coat and sperm. The findings, presented in Nature, gives a first glimpse into the molecular architecture of animal egg coats, with important implications for the future of human reproductive medicine and the possibility of developing novel contraceptives.

The beginning of every new life starts with fertilization, the most crucial step of which is the initial species-specific recognition between egg and sperm. The receptors for sperm, proteins ZP3 and ZP2, contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein Crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N domain.

"ZP3 was identified almost 30 years ago, but obtaining structural information on this key reproductive protein has been technically challenging due to its high heterogeneity", says Luca Jovine.

The zona pellucida is essential for natural fertilization in mammals. The Karolinska Institutet researchers hope that X-ray crystallographic characterization of a region of ZP3 that is important for its ability to polymerize could help explaining cases of human infertility, as well as lead to the development of novel targeted, non-hormonal contraceptives. The research made on the ZP-N domain has also provided insights that extend beyond the field of reproduction. Among other things, an unexpected parallel has been uncovered with molecular features that are involved in speciation among invertebrates.

Moreover, ZP-N domains are also found in many other extracellular proteins that are unrelated to fertilization, but play important roles in human diseases such as non-syndromic deafness, renal and vascular disorders, and cancer. In the Nature paper, an example is discussed that shows how the structure of ZP-N can be used to understand the molecular basis of some of these disorders.

"Mammalian fertilization involves a highly complex series of events. Our findings pave the way for future investigations into this fascinating subject by providing a first snapshot of the beginning of life at atomic resolution", says Luca Jovine.


'/>"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. Survey reveals disparities in skin cancer knowledge, protection among high school students
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. Inc. Magazine Reveals Its 26th Annual List of Americas 500 Fastest-Growing Private Companies
5. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
6. New Survey Reveals Kidney Patients Concern About Medicare Policies
7. UCSD study reveals the regulatory mechanism of key enzyme
8. UCSD study reveals the regulatory mechanism of key enzyme
9. Poll reveals public awareness of nanotech stuck at low level
10. Survey reveals ignorance and confusion about cancer amongst the elderly
11. Story Reveals How Isabel and Her Family Learn About Bone Health and Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... Boston, MA and Orlando, FL (PRWEB) , ... ... ... Strohbusch, Orbita PR Director, beth[at]orbitahealth[dot]com, +1 (414) 213-8818 , Orbita, Inc., a leading ... ™, a complete software-as-a-service solution for increasing patient engagement and optimizing care journey ...
(Date:2/20/2017)... Plano, Texas (PRWEB) , ... February 20, 2017 ... ... vital signs technology, welcomes you to stop by for a visit this week ... IT professionals, clinicians and executives from around the globe. Sensogram will be featured ...
(Date:2/20/2017)... (PRWEB) , ... February 20, 2017 , ... Chuck E. ... Sensory Sensitive Sundays, a joint event at Chuck E. Cheese’s locations throughout New England, ... other special needs, the opportunity to experience the fun of visiting Chuck E. Cheese’s ...
(Date:2/19/2017)... ... , ... ProBrand Glitch is a set of 30 glitch distortion logo reveals made exclusively for ... logo with a glitch reveal in just a few clicks of a mouse. Customizable glitch ... each preset. Use these presets to add a uniquely animated logo to any photos or ...
(Date:2/18/2017)... ... February 17, 2017 , ... Butler Mobility invited Ken ... Stairlift and other Butler products. Ken was impressed with the safety and reliability ... endorse the product on his show. This endorsement by Ken Matthews can be ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... LONDON , February 20, 2017 Acute, Chronic ... is expected to grow at a CAGR of 7% from 2016-2021 and ... a CAGR of 6% from 2016 to 2027. The market is estimated ... ... Read on to discover how you can exploit the future business ...
(Date:2/19/2017)... , February 18, 2017 ... agreement to purchase a Medical Delivery Service with the ... cannabis transactions between qualified patients and caregivers. The delivery ... , located in the Coachella Valley, California ... Greater Los Angeles area to the West, ...
(Date:2/18/2017)... , Feb. 17, 2017 Research and Markets ... Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Latin America ... the period 2015 through 2022. Also, a six-year historic analysis is provided ...
Breaking Medicine Technology: