Navigation Links
Crystallography reveals the 3-D structure of mammalian sperm receptor
Date:12/4/2008

Scientists at the Swedish medical university Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for the interaction between the mammalian egg coat and sperm. The findings, presented in Nature, gives a first glimpse into the molecular architecture of animal egg coats, with important implications for the future of human reproductive medicine and the possibility of developing novel contraceptives.

The beginning of every new life starts with fertilization, the most crucial step of which is the initial species-specific recognition between egg and sperm. The receptors for sperm, proteins ZP3 and ZP2, contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein Crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N domain.

"ZP3 was identified almost 30 years ago, but obtaining structural information on this key reproductive protein has been technically challenging due to its high heterogeneity", says Luca Jovine.

The zona pellucida is essential for natural fertilization in mammals. The Karolinska Institutet researchers hope that X-ray crystallographic characterization of a region of ZP3 that is important for its ability to polymerize could help explaining cases of human infertility, as well as lead to the development of novel targeted, non-hormonal contraceptives. The research made on the ZP-N domain has also provided insights that extend beyond the field of reproduction. Among other things, an unexpected parallel has been uncovered with molecular features that are involved in speciation among invertebrates.

Moreover, ZP-N domains are also found in many other extracellular proteins that are unrelated to fertilization, but play important roles in human diseases such as non-syndromic deafness, renal and vascular disorders, and cancer. In the Nature paper, an example is discussed that shows how the structure of ZP-N can be used to understand the molecular basis of some of these disorders.

"Mammalian fertilization involves a highly complex series of events. Our findings pave the way for future investigations into this fascinating subject by providing a first snapshot of the beginning of life at atomic resolution", says Luca Jovine.


'/>"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. Survey reveals disparities in skin cancer knowledge, protection among high school students
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. Inc. Magazine Reveals Its 26th Annual List of Americas 500 Fastest-Growing Private Companies
5. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
6. New Survey Reveals Kidney Patients Concern About Medicare Policies
7. UCSD study reveals the regulatory mechanism of key enzyme
8. UCSD study reveals the regulatory mechanism of key enzyme
9. Poll reveals public awareness of nanotech stuck at low level
10. Survey reveals ignorance and confusion about cancer amongst the elderly
11. Story Reveals How Isabel and Her Family Learn About Bone Health and Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... ... Everseat digital self-scheduling readily available to physicians. The integration will enable Allscripts ... and select appointments via Everseat’s free mobile app. , The partnership gives Everseat ...
(Date:2/10/2016)... ... ... Workrite Ergonomics, who is celebrating their 25th year of business in 2016, is ... recognized leader in their industry. , "We are very proud of our heritage and ... “Workrite recognized the importance of good ergonomics before most of our competition even knew ...
(Date:2/10/2016)... Puente, California (PRWEB) , ... February 09, 2016 ... ... Medicine students, faculty and staff helped give free oral screenings to 150 children ... Feb. 5, 2016. , The College of Dental Medicine joined Chinese American Dental ...
(Date:2/10/2016)... ... February 10, 2016 , ... It’s that time of year when most people ... the Interscholastic Athletic Association of Maryland (IAAM), Hall of Fame athlete and Garrison Forest ... cast aside. , That’s why one of her first decisions when her IAAM two-year ...
(Date:2/9/2016)... ... February 09, 2016 , ... February is Heart Awareness ... Rate Variability scans throughout the month to the American Heart Association, New Mexico chapter. ... signs of heart disease and Health Quest’s INSiGHT Pulse Wave Profiler utilizes a non-invasive ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... YORK , Feb. 9, 2016 The life ... Langone Medical Center, has been anything but ordinary.  Twists of ... of World War II and the constraints of communist Czechoslovakia ... 1960s; there, he would go on to make history by ... the three best-selling drugs in the world, Remicade.  Dr. Vilcek ...
(Date:2/9/2016)... LONDON , Feb. 9, 2016 The new report ... Forecast: 2015-2019" by Spearhead Acuity Business Research & Consulting group reveals ... fetal and neonatal market with a share of 36.4% in 2014 ... North America , the report also covers market analysis for ... Europe , Asia-Pacific , ...
(Date:2/9/2016)... report "Global Anti-Bacterial Drugs Market Assessment & Forecast: 2015 - 2019" ... North America continued to lead global anti-bacterial ... into revenues worth US$ 16,907.3 million. North ... , Latin America , Middle-East ... market is inclined towards North America and ...
Breaking Medicine Technology: