Navigation Links
Crystallography reveals the 3-D structure of mammalian sperm receptor
Date:12/4/2008

Scientists at the Swedish medical university Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for the interaction between the mammalian egg coat and sperm. The findings, presented in Nature, gives a first glimpse into the molecular architecture of animal egg coats, with important implications for the future of human reproductive medicine and the possibility of developing novel contraceptives.

The beginning of every new life starts with fertilization, the most crucial step of which is the initial species-specific recognition between egg and sperm. The receptors for sperm, proteins ZP3 and ZP2, contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein Crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N domain.

"ZP3 was identified almost 30 years ago, but obtaining structural information on this key reproductive protein has been technically challenging due to its high heterogeneity", says Luca Jovine.

The zona pellucida is essential for natural fertilization in mammals. The Karolinska Institutet researchers hope that X-ray crystallographic characterization of a region of ZP3 that is important for its ability to polymerize could help explaining cases of human infertility, as well as lead to the development of novel targeted, non-hormonal contraceptives. The research made on the ZP-N domain has also provided insights that extend beyond the field of reproduction. Among other things, an unexpected parallel has been uncovered with molecular features that are involved in speciation among invertebrates.

Moreover, ZP-N domains are also found in many other extracellular proteins that are unrelated to fertilization, but play important roles in human diseases such as non-syndromic deafness,
'/>"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. Survey reveals disparities in skin cancer knowledge, protection among high school students
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. Inc. Magazine Reveals Its 26th Annual List of Americas 500 Fastest-Growing Private Companies
5. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
6. New Survey Reveals Kidney Patients Concern About Medicare Policies
7. UCSD study reveals the regulatory mechanism of key enzyme
8. UCSD study reveals the regulatory mechanism of key enzyme
9. Poll reveals public awareness of nanotech stuck at low level
10. Survey reveals ignorance and confusion about cancer amongst the elderly
11. Story Reveals How Isabel and Her Family Learn About Bone Health and Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... (PRWEB) February 28, 2015 A study ... promising new gene therapy procedure for the treatment of ... in patients. Authored by Dr. Robert MacLaren, ... published in the Lancet Medical Journal on January 16, ... choroideremia, a rare genetic disorder that mostly affects men ...
(Date:2/28/2015)... February 28, 2015 Pioneer Millworks reclaimed ... Japan Architecture & Construction Materials Show, an annual, premier ... than 1,000 suppliers and top manufacturers of the latest ... wood products sourced and manufactured by Pioneer Millworks ... popularity in Japan at restaurants, hotels, retailers, and corporate ...
(Date:2/28/2015)... India Network Foundation, a US ... programs for visitors coming to the United States for ... to the United States are suffering from one or ... These diseases are so common among the elderly population ... conditions. There were 66.8 million cases of diabetes in ...
(Date:2/28/2015)... How would you describe your leadership ... all kinds of different leaders, each with their ... advantages and applications of different leadership styles, Ohio-based ... product this spring called The Leadership Report that ... personality type, leadership, and success. The Leadership Report ...
(Date:2/28/2015)... Toronto, ON (PRWEB) February 28, 2015 ... the Art of Facial Surgery was recently featured in ... 82 of the magazine, Dr. David Ellis was featured ... He discussed the various cosmetic enhancements that Kim Cattrall ... skin. , “Her forehead is smooth without horizontal ...
Breaking Medicine News(10 mins):Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2Health News:US Reclaimed Wood from Pioneer Millworks to be Featured at Architecture & Construction Materials Show in Tokyo. 2Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 2Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 3Health News:PeopleKeys Launches The Leadership Report 2Health News:PeopleKeys Launches The Leadership Report 3Health News:Dr. David Ellis Featured In Elevate Magazine 2
... Function Drinks,announced today the launch of their ... on supporting sexual health. Function: Night Life ... amino acid, tyrosine, to provide,the building blocks ... with reward and desire. Epimedium, niacin and,cnidium ...
... for ... consumers, PRINCETON, N.J., June ... care products,announced today that its key product line, MEDIHONEY(TM) Wound & Burn,Dressings ... counter (OTC) sales. This will provide consumers with expanded,access to the products ...
... Kiner has,been named vice president and general manager ... In this new role, Stewart is responsible for,providing ... senior market lines of business, including Medicare Advantage ... Kiner will report to,Karen Vigil, senior vice president ...
... 24 Speaker Nancy Pelosi,issued the following statement ... Act, which passed the House this afternoon by ... bipartisan and veto-proof vote sends a strong signal ... for providers will not,be held hostage to the ...
... Zuccari,President & CEO of Hamilton Insurance Agency is featured ... Health Care Association this,June for his recent work with ... by the AHCA," said Alan J. Zuccari. "I,am proud ... focus is providing quality care.", Below is the ...
... supply, study suggests , , TUESDAY, June 24 (HealthDay News) ... help reduce a form of brain injury that affects ... study. , Hypoxic-ischemia, a compromise of the brain,s ... and cognitive/behavioral problems. , In experiments with rats that ...
Cached Medicine News:Health News:Function Drinks Launches New Product to Support Sexual Health 2Health News:Derma Sciences Receives FDA Clearance to Sell MEDIHONEY(TM) Over the Counter 2Health News:Derma Sciences Receives FDA Clearance to Sell MEDIHONEY(TM) Over the Counter 3Health News:Blue Shield of California Appoints Industry Veteran as New Vice President and General Manager for Senior Market 2Health News:Alan J. Zuccari Featured by the American Health Care Association as a June PAC Member 2Health News:Alzheimer's Drug May Reduce Preemie Brain Injury 2
(Date:2/27/2015)...  Uroplasty, Inc. (NASDAQ: UPI ), a medical ... products to treat voiding dysfunctions, today announced that it ... Tuesday, March 10, 2015. Rob Kill , President ... Officer, will present at 4:00 p.m. Pacific Time and ... at the Ritz Carlton in Laguna Niguel, ...
(Date:2/27/2015)... 27, 2015  Two mass spectrometry technologies ... as their effectiveness is established, according to ... Information says that while mass spectrometry (mass ... tool in proteomic biomarker discovery and validation, ... traditional techniques has struggled to elucidate molecular ...
(Date:2/26/2015)... , Feb. 26, 2015  Tandem Diabetes Care®, Inc. ... and manufacturer of the t:slim® and t:flex™ Insulin Pumps, ... of 5,250,000 shares of its common stock at a ... net proceeds to Tandem from this offering are expected ... commissions and other estimated offering expenses payable by Tandem. ...
Breaking Medicine Technology:Uroplasty to Participate in the 27th Annual ROTH Conference 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 2Tandem Diabetes Care Announces Pricing of Underwritten Public Offering of Common Stock 3
... LONDON, March 2, 2012  ConvaTec, a world-leading developer ... and hospital care today announced that Amcare Ltd, ... has acquired SureCalm Healthcare Holdings Ltd and subsidiaries ... specialises in the home delivery of prescribable stoma ...
... Mich., March 2, 2012 Rubicon Genomics, Inc., ... to improve the capabilities and performance of DNA ... has selected Velesco Pharmaceutical Services to manufacture the ... with Agendia,s breast cancer diagnostics.  Velesco is a ...
Cached Medicine Technology:ConvaTec Announces Acquisition of SureCalm Healthcare 2Rubicon Genomics Selects Velesco to Manufacture its TransPLEX® RNA Amplification Kits for Clinical Diagnostic Use 2Rubicon Genomics Selects Velesco to Manufacture its TransPLEX® RNA Amplification Kits for Clinical Diagnostic Use 3
... a centimeter ruler etched into the gel tray ... includes apparatus, connecting cables, three 7x10 cm gel ... three 14-well combs. The Chameleon can accomodate up ... of a maximum of 120 samples with a ...
... of a Separation-Control unit for system control ... gel staining. The optional PhastTransfer Kit quickly ... unit. Electrophoresis is performed on a thermostatic ... 0 to +70 C. Multi-step programming capability ...
... The SEA 2000 apparatus and ready-to-use gels ... for analysis of nucleic acids by submerged ... complete this system, offering full compatibility and ... Besides the SEA 2000 and a unique ...
... SEA 2000 apparatus and ready-to-use gels are ... analysis of nucleic acids by submerged gel ... this system, offering full compatibility and optimal ... the SEA 2000 and a unique staining ...
Medicine Products: