Navigation Links
Crystallography reveals the 3-D structure of mammalian sperm receptor
Date:12/4/2008

Scientists at the Swedish medical university Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for the interaction between the mammalian egg coat and sperm. The findings, presented in Nature, gives a first glimpse into the molecular architecture of animal egg coats, with important implications for the future of human reproductive medicine and the possibility of developing novel contraceptives.

The beginning of every new life starts with fertilization, the most crucial step of which is the initial species-specific recognition between egg and sperm. The receptors for sperm, proteins ZP3 and ZP2, contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein Crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N domain.

"ZP3 was identified almost 30 years ago, but obtaining structural information on this key reproductive protein has been technically challenging due to its high heterogeneity", says Luca Jovine.

The zona pellucida is essential for natural fertilization in mammals. The Karolinska Institutet researchers hope that X-ray crystallographic characterization of a region of ZP3 that is important for its ability to polymerize could help explaining cases of human infertility, as well as lead to the development of novel targeted, non-hormonal contraceptives. The research made on the ZP-N domain has also provided insights that extend beyond the field of reproduction. Among other things, an unexpected parallel has been uncovered with molecular features that are involved in speciation among invertebrates.

Moreover, ZP-N domains are also found in many other extracellular proteins that are unrelated to fertilization, but play important roles in human diseases such as non-syndromic deafness, renal and vascular disorders, and cancer. In the Nature paper, an example is discussed that shows how the structure of ZP-N can be used to understand the molecular basis of some of these disorders.

"Mammalian fertilization involves a highly complex series of events. Our findings pave the way for future investigations into this fascinating subject by providing a first snapshot of the beginning of life at atomic resolution", says Luca Jovine.


'/>"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. Survey reveals disparities in skin cancer knowledge, protection among high school students
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. Inc. Magazine Reveals Its 26th Annual List of Americas 500 Fastest-Growing Private Companies
5. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
6. New Survey Reveals Kidney Patients Concern About Medicare Policies
7. UCSD study reveals the regulatory mechanism of key enzyme
8. UCSD study reveals the regulatory mechanism of key enzyme
9. Poll reveals public awareness of nanotech stuck at low level
10. Survey reveals ignorance and confusion about cancer amongst the elderly
11. Story Reveals How Isabel and Her Family Learn About Bone Health and Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... , ... February 27, 2017 , ... Robert E. Burke, ... medical group. But his impoverished upbringing and life experiences could have led him down ... Physician: Insightful and Inspirational Tales of Parenting, Perseverance and Pediatrics,” Dr. Burke shares a ...
(Date:2/27/2017)... TN (PRWEB) , ... February 27, 2017 , ... The ... Clayton went to work for a company involved in the underground testing of nuclear ... In “Dying for Answers: Expendable Workers of the Cold War Nuclear Testing,” Clayton exposes ...
(Date:2/27/2017)... , ... February 27, 2017 , ... ... an overview on laser diffraction analysis as a tool to characterize particle size ... and potential to obtain improved results and novel scientific findings. It describes methods ...
(Date:2/27/2017)... TX (PRWEB) , ... February 27, 2017 , ... ... 75,000 customer threshold mark last week. In addition, Discount Power's RCE (Residential Customer ... Energy LLC in March 2014. The company had 800 customers and 2,250 RCEs ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair ... to announce an upgrade to the company's Yelp listing. Bay Area residents struggling ... as diverse as Platelet Rich Plasma (PRP) therapy, hair transplantation techniques such as ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... 27, 2017 Now in its seventh ... that are most successful at developing and commercialising innovation. ... The Index ... same molecule to two different companies in early phase, which ... systematic, objective analysis of each company,s performance between 2011 and 2016, the ...
(Date:2/27/2017)... -- CTI BioPharma Corp. (CTI BioPharma) (NASDAQ and MTA: CTIC) today ... as President and Chief Executive Officer (CEO) and member of ... succeeds Richard Love , interim President and CEO who ... Dr. Craig has over 20 years of experience in hematology, ... Europe . "On behalf of CTI ...
(Date:2/27/2017)... , Feb 27, 2017 The ... by NATO for use at the security level RESTRICTED. The ... the NATO organization for the communication of classified information. ... Sectra and ... with an eavesdrop-secure smartphone solution. Sectra Tiger/R is developed by ...
Breaking Medicine Technology: