Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuti...( NEW YORK Sept. 11 /- Crystal Rese...),Health

NEW YORK, Sept. 11 /PRNewswire/ -- Crystal Research Associates, LLC announced today that it has issued an Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuticals, Inc. (Nasdaq: TPPH). The full 60-page report can be found at http://www.crystalra.com.

Tapestry Pharmaceuticals, Inc. ("Tapestry" or "the Company") is a biopharmaceutical company developing New Chemical Entities that may be effective in treating a broad spectrum of cancers. The Company's lead compound, TPI 287, is a novel, proprietary, third-generation taxane. Although taxanes have been used as cancer therapies for many years, treatment with these drugs is often plagued by undesirable effects, the most notable of which is the emergence of multi-drug resistance (MDR). To address this, Tapestry is developing TPI 287, which has shown the ability to overcome MDR in preclinical experiments.

In particular, TPI 287 targets MDR-1 (the primary mechanism responsible for tumor resistance to taxanes). TPI 287 has also shown efficacy in preclinical studies in a broad range of cell lines versus comparator drugs. Furthermore, in animal models, TPI 287 has shown greater oral bioavailability than paclitaxel, an approved taxane.

The Company filed an Investigational New Drug (IND) application for TPI 287 with the U.S. Food and Drug Administration (FDA) and commenced two Phase 1 studies, each with a different dosing regimen. The first Phase 1 study, which began in January 2005, employed a Q7D X3 regimen (dosing every seven days for three weeks), while the second Phase 1 study, which started in January 2006, used a Q21D (dosing every 21 days) regimen. The objectives of these Phase 1 trials we
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