Navigation Links
Crucial sex hormones re-routed by missing molecule
Date:11/29/2010

A hormone responsible for the onset of puberty can end up stuck in the wrong part of the body if the nerve pathways responsible for its transport to the brain fail to develop properly, according to research funded by the Biotechnology and Biological Sciences Research Council (BBSRC).

By tracking how nerve cells responsible for regulating sexual reproduction in mice find their way from their birth place in the foetal nose to their site of action in the adult brain, scientists from University College London (UCL) have found that if a certain molecule is missing, then these pathways are not formed correctly and gonadotropin releasing hormone (GnRH) can become lodged in the nose or the forehead, rather than in the brain, where it is needed to control the menstrual cycle in females and testosterone production in males.

Speaking about the findings, published today (29 November) in Human Molecular Genetics, co-investigator Dr Christiana Ruhrberg explains: "We discovered that a molecule essential for the growth of the nerve cables that transmit odour and pheromone signals from the nose to the brain is also crucial in the development of the highways responsible for transporting other nerve cells that make the sex hormone GnRH. We found that in mice with an inherited deficiency in the molecule SEMA3A, these highways did not lead to the brain, but instead formed impenetrable tangles outside the brain. This means that the nerve cells making GnRH are unable to get to their final destination and instead become stuck in the nose or forehead."

As a result the researchers found that the testes of mice lacking SEMA3A did not grow properly and the adult males were infertile. These findings have important implications for the study of Kallmann's syndrome and related genetic disorders that causes infertility.

Professor Douglas Kell, BBSRC Chief Executive said "This study highlights the importance of understanding the very earliest developmental processes of the brain, including how and where cells develop, how they migrate and how and where they mature. Such fundamental bioscience research helps drive medical advances by providing clues about the development of a variety of disorders which present huge challenges to individuals, their families and our wider society."


'/>"/>

Contact: Mike Davies
mike.davies@bbsrc.ac.uk
01-793-442-042
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. NIH Recovery Act awards enable crucial health research technologies
2. Study finds that cancer-causing gene crucial in stem cell development
3. Water management and malnutrition crucial issues at McGill food conference
4. A high-fat diet alters crucial aspects of brain dopamine signaling
5. Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports
6. A more active lifestyle crucial for day-to-day function in COPD patients
7. Concord Coalition Reacts To Health Care Bill Passage: Cost Control Vigilance is Now Crucial
8. Organic Clothing can be as Crucial to Your Health as Organic Food or Yoga
9. Study finds why some women are sub-fertile with a poor response to ovarian stimulating hormones
10. Upcoming Simulcast to Teach Women How to Lose Weight and Naturally Balance Hormones with Polycystic Ovarian Syndrome
11. Women with Polycystic Ovarian Syndrome and Insulin Resistance can Lose Weight and Balance Hormones Naturally with Katie Humphrey's New E-book
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and ... and financial preparation services, is providing an update on a charitable event that ... City Rescue is a locally recognized nonprofit that provides shelter and care for ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/19/2017)... venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound ... ... Jim Bertolina, PhD ... Tom Tefft ... device executive Josh Stopek , PhD, who has led R&D and business development teams ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
Breaking Medicine Technology: