Navigation Links
Cross-species transplant in rhesus macaques is step toward diabetes cure for humans
Date:10/18/2007

ccess of the transplants.

As a treatment for diabetes in people, pig insulin typically works as well as the human form. Before recombinant DNA technology enabled pharmaceutical companies to manufacture human insulin in the 1980s, pig and cow insulin were routinely given to diabetic patients.

The primates in the current study had type 1 diabetes, the form that occurs when islet cells in the pancreas stop producing insulin all together. The Washington University researchers transplanted 19 embryonic pig pancreatic primordia into each diabetic monkey. Each primordium is smaller than the diameter of a period that ends a sentence and is transplanted into a membrane that envelops the intestines and other digestive organs.

The transplanted cells were retrieved from the pig embryos early in their development, which is believed to render them "invisible" to the primates' immune system or induce a state of tolerance, either of which eliminates the need for immune suppression.

The researchers determined by multiple methods that the transplanted cells became established within the primates. And as the cells matured, they began to release pig insulin. "We found using every method that the cells engraft long-term and, thus, are not rejected by the animals' immune systems," Hammerman says. "It's been more than two years since our first transplant was carried out. That particular primate doesn't produce any primate insulin, but has pig insulin circulating in its bloodstream that has reduced by more than 50 percent the amount of injected insulin the animal needs, compared to levels before the transplant. The animals have never received immune suppression drugs."

Two of the macaques remain healthy. One, however, became anemic about six weeks post-transplant and was euthanized a month later after developing acute respiratory distress. The researchers could not find a link between this animal's illness and the pancreatic cell transplants.

The two remaining m
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Infant receives first bloodless liver transplant
2. Liver donors can thrive after transplant
3. ATG useful in transplant patients as substitute for steroids
4. Transplant helps diabetes
5. Larynx transplant restores patients voice after 20 years
6. Baby Lennox Gets Liver Transplant
7. Chinese Girl To Undergo Face Transplant Surgery
8. Stem cell transplantation of eye
9. Woman gets cancer from transplanted kidney
10. Parasite infections linked to organ transplants
11. Vitamins enhances recuperation of organ transplant patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... (PRWEB) February 28, 2015 The ... its annual awards at the International Symposium on Malignant ... be held at the Hyatt Regency Bethesda in Bethesda, ... their dedicated work and commitment to the mission to ... Year Award will be presented to Miriam Ratner. Miriam ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 A case ... testosterone lawsuits that have been filed by law firms ... second week in March, the Firm notes. , ... parties involved in the federal litigation will meet on ... related to prescription therapy treatments designed to raise levels ...
(Date:2/28/2015)... The noted Toronto plastic surgeon Dr. David Ellis ... in the January/February 2015 issue of Elevate magazine. On ... featured in an article entitled “Get the Look: Kim ... Cattrall has possibly undergone to maintain her youthful appearance ... horizontal lines or frown line creases, which can be ...
(Date:2/28/2015)... February 28, 2015 Memphis, TN: MedixSafe ... 2015, for a new security reader named Guardian ... reader is a new biometric scanner that significantly ... new features, the new biometric scanner provides fast ... administrators. , MedixSafe narcotics lockers with ...
(Date:2/27/2015)... Wireless Analytics, an award-winning ... of the founders of the wireless expense ... within their CLEAN Platform™ (Communications Lifecycle Expense Analytics) ... newly developed Bell Mobility Data Loader enables unprecedented ... carrier’s business customers. , Wireless Analytics cites customer ...
Breaking Medicine News(10 mins):Health News:Cancer Research Foundation Honors Award Recipients 2Health News:Cancer Research Foundation Honors Award Recipients 3Health News:Cancer Research Foundation Honors Award Recipients 4Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 2Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 3Health News:Bernstein Liebhard LLP Notes Approaching Conference in Federal Litigation that Includes Numerous Testosterone Lawsuits Filed by the Firm 4Health News:Dr. David Ellis Featured In Elevate Magazine 2Health News:New Name Announced For Newest MedixSafe Readers – MedixSafe Vanguard 2Health News:Bell Mobility Gains Traction With Enterprises; Is Added to Wireless Analytics’ CLEAN Platform™ 2Health News:Bell Mobility Gains Traction With Enterprises; Is Added to Wireless Analytics’ CLEAN Platform™ 3
... SALT LAKE CITY, Dec. 17 Dynatronics Corporation (Nasdaq: ... board of directors and the execution of an agreement ... aid in strategic planning and improved corporate profitability. On ... with Vici Capital Partners for consulting services through its ...
... al. released this week and scheduled to be published in ... Medicine , concluded that while screening colonoscopy is associated with ... to deaths from cancer developing in the left side of ... a screening test and clarifies a possible weakness: detecting ...
... Researchers at Thomas Jefferson University have found that ... acoustic neuromas results in better hearing preservation and ... a higher dose of therapy. The study appeared ... Oncology*Biology*Physics . , "We previously had not determined ...
... between facilities also had higher mortality rates, study says ... those lacking insurance, make up the bulk of children ... , The study, published in a recent issue of ... that children who were transferred between hospitals died in ...
... SURGERY,S WORK COMES TO LIFE , , ... surgery. In fact, Maria Siemionow, MD, who performed this country,s ... reconstructive plastic surgeon. Facial transplantation plastic surgery offers great hope ... , "The nation,s first face transplant ...
... A new U.S. study has found that being circumcised ... African American men known to have been exposed to ... clinical trials in Africa, where interventional use of adult ... in heterosexual men. The findings of the new study, ...
Cached Medicine News:Health News:Dynatronics Announces Changes to Board and Launches Operational Improvement Process 2Health News:Annals colonoscopy study underscores importance of quality standards 2Health News:Lower-dose fractionated stereotactic radiotherapy results in better hearing preservation 2Health News:Newborn Hospital Deaths Highest for Those Without Insurance 2Health News:Plastic Surgery Experts Available to Comment on Face Transplant Surgery 2Health News:Circumcision reduces the risk of HIV infection in heterosexual US men 2
(Date:2/27/2015)... , Feb. 27, 2015  Following a ... Committee that moved H.R. 284, the Medicare DMEPOS ... American Association for Homecare (AAHomecare) released a statement ... action to pass the legislation. "Today,s ... the House Ways and Means Committee is a ...
(Date:2/27/2015)... -- Securities lawyers at Dunnam & Dunnam ... SLXP ) in connection with a buyout ... encouraged to contact attorney Hamilton Lindley by clicking ... the shareholder value of the transaction. Under terms of ... per share in cash. At least one analyst has ...
(Date:2/27/2015)... HOUSTON, TX , Feb. 27, 2015 /PRNewswire/ - ESSA ... Bloom Burton & Co. Ltd. ("Bloom Burton") today announced ... "Lock-Up") 2,353,130 common shares of the Company ("Common Shares") ... the Lock-Up. Of the Common Shares released from the ... release from the Lock-Up while the remainder will be ...
Breaking Medicine Technology:Bidding Fix Takes Major Step Forward After Bipartisan Vote of House Ways and Means Committee 2ESSA Pharma and Bloom Burton announce additional release of shares from voluntary lock-up agreement 2ESSA Pharma and Bloom Burton announce additional release of shares from voluntary lock-up agreement 3ESSA Pharma and Bloom Burton announce additional release of shares from voluntary lock-up agreement 4
... Sleep, the West Coast,s largest and fastest growing independent ... sleep clinic in Oakland, California.  Located one block from ... open for business. Services include sleep physician consultations, diagnostic ... other therapies for patients diagnosed with Obstructive Sleep Apnea ...
... Nov. 14, 2011 NeuroCog Trials, Inc. and Advance ... recordings of neurocognitive testing in a large international clinical ... errors in test administration and scoring.  This video recording ... accurate, unbiased assessment of neuropsychological effects of new drugs. ...
Cached Medicine Technology:Bay Sleep Clinic Continues Growth in California and Beyond 2NeuroCog Trials Captures Video Recordings of Neurocognitive Testing in a Multinational Clinical Trial 2NeuroCog Trials Captures Video Recordings of Neurocognitive Testing in a Multinational Clinical Trial 3
... a new implant. It's a new material, ... debris can be greatly reduced . The ... needs of the nickel-sensitive patient. Hardness, lubricity ... Oxinium is available in our two already ...
... anatomic knee system was ... minimize polyethylene wear between ... minimize contact stress associated ... achieve a well balanced ...
Simplified Design-Based on 15 Years of Experience...
... of more than a decade of in-vivo ... a comprehensive study of knee kinematics through ... insert retrieval analysis.,As a result of this ... motion patterns in total knees, the 3DKnee ...
Medicine Products: