Navigation Links
Critical protein discovered for healthy cell growth in mammals
Date:1/27/2014

A team of researchers from Penn State University and the University of California has discovered a protein that is required for the growth of tiny, but critical, hair-like structures called cilia on cell surfaces. The discovery has important implications for human health because lack of cilia can lead to serious diseases such as polycystic kidney disease, blindness and neurological disorders.

"If we want to better understand and treat diseases related to cilium development, we need to identify important regulators of cilium growth and learn how those regulators function," said co-author Aimin Liu, associate professor of biology at Penn State. "This work gives us significant insight into one of the earliest steps in cilium formation."

The researchers describe their findings in a paper that will be published online in the Proceedings of the National Academy of Sciences during the week of 27 January 2014. In addition to Liu, authors include Penn State cellular biologists Xuan Ye, Huiqing Zeng and Gang Ning, as well as Jeremy F. Reiter, a biophysicist at the University of California - San Francisco.

Cilia, which are present on the surface of almost all mammalian cells, are responsible for sending, receiving, and processing information within the body. "You could think of cilia as the cells' antennae," Liu said. "Without cilia, the cells can't sense what's going on around them, and they can't communicate." Cilia also perform important filtering and cleansing functions. For example, cilia inside the trachea, or windpipe, trap and prevent bacteria from entering the lungs.

In a previous study, Liu and his colleagues learned that a protein called C2cd3 is important for cilium formation because mice that lacked this protein exhibited severe developmental problems typically associated with the lack of cilia. "At the time we knew only that if we get rid of the protein, the cells in the animal would not grow cilia," Liu said. "We didn't understand why, but now we do."

A cilium grows from a centriole, a structure that clings to the inner surface of the cell and serves as an anchor for the cilium. Before a cell can grow a cilium, it needs to assemble a set of appendages at one end of the centriole. These appendages can then connect the centriole to the cell surface, allowing the outgrowth of a cilium. Just how these appendages are assembled, though, remained a mystery for more than four decades since their discovery in 1962. Liu and his colleagues found that appendages were not assembled at the end of the centriole when the C2cd3 protein is not present. As a result, the centriole is not associated with the cell membrane and cannot recruit other proteins for the further growth of the cilium. "So our protein is required for the very first step of putting a cilium together," Liu explained. "Without those appendages, the cilium growth cannot happen."

The researchers hope their discovery will lead to greater knowledge of the process of cilium development and, eventually, to treatments for a wide range of health problems that fall under the label of ciliopathy. "Ciliopathy is a scientific term that covers a lot of diseases," Liu said. As well as contributing to cystic disorders in the kidney and liver, lack of cilia can lead to blindness or deafness, since cilia in the retina serve as receptors that process light stimulation and cilia within the ear are required in neurons that translate sound waves into neural signals.


'/>"/>

Contact: Barbara K. Kennedy
sciencew@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Related medicine news :

1. Need for Mosquito Control Becoming More Critical
2. Life Insurance To Cover Funeral Costs Or Critical Illness Plans? What Should Seniors Choose?
3. Is Critical Bench Program The Effective Solution For Building Muscle? – Vinamy
4. Critical Bench: Review Exposes Mike Westerdal’s Muscle and Strength Building Program
5. Middle East Critical Infrastructure Protection (CIP) Market (Technology, Solutions, Services) Worth $13.07 Billion by 2018 - New Report by MarketsandMarkets
6. Human neural stem cells could meet the clinical problem of critical limb ischemia
7. UC Irvine Health Appoints William C. Wilson, MD, as Director of Critical Care Services
8. Global Food Exchange Responds to Critical Need in the Philippines
9. UC Irvine Health Appoints William C. Wilson, MD, as Hospital Director of Critical Care Services, Division of the Department of Anesthesiology & Perioperative Care
10. Discover Innovative Upper Body Exercises With The “Critical Bench” Course – Vkoolelite
11. Critical Care Medicine Expert from The Children’s Hospital of Philadelphia Receives Distinguished Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Critical protein discovered for healthy cell growth in mammals
(Date:12/8/2016)... ... ... Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the launch of ... headquarters of Omni La Costa Resort & Spa in San Diego. , Chopra FIT ... development, a healthy lifestyle, or mental and physical healing. The week-long wellness program combines ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... development continuity to its innovative Unified Instance Manager architecture, meeting the needs ... this new version optimizes the unattended auto-dialing system without agents, Presence Robodialer, ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... Center has been recognized for adherence to the highest standards of trauma, ... accreditation organizations, announced the center's president and CEO, Dr. Daniel Messina. , Among ...
(Date:12/8/2016)... ... December 08, 2016 , ... California Senate Bill (SB) 863, ... workers’ compensation claim in 2013 and 2014, according to CompScope™ Medical Benchmarks for ... . , According to the study, medical payments per claim in California decreased 4 ...
(Date:12/8/2016)... Charlotte, NC (PRWEB) , ... December 08, 2016 ... ... repeal Medicare and the Affordable Care Act. Dr. Botelho advocates for the mass ... A story movement gives people ongoing opportunities to share their unfortunate experiences; such ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... CITY , Dec. 8, 2016 ... US patents for improving the accuracy, reproducibility and ... images in long and small bone orthopaedic applications. ... approach to creating personalized orthopaedic restorations based on ... personalized orthopaedic restorations, the company harnesses the world,s ...
(Date:12/8/2016)... Dec. 8, 2016  EIP Pharma, LLC ( ... proof-of-mechanism for neflamapimod (previously code named VX-745), with ... clinical trials that demonstrated significant Alzheimer,s disease relevant ... treatment) and Study 303 (6-week treatment) are the ... Alzheimer,s Disease (CTAD) scientific conference in ...
(Date:12/8/2016)... Dignitana, a world leader in medical scalp-cooling ... creator of the award-winning, patented Boa® system, to produce ... DigniCap® scalp cooling system. DigniCap® was cleared by the ... is the first medical scalp cooling device to receive ... features a patented tight-fitting silicone cooling cap that is ...
Breaking Medicine Technology: