Navigation Links
Critical protein discovered for healthy cell growth in mammals
Date:1/27/2014

A team of researchers from Penn State University and the University of California has discovered a protein that is required for the growth of tiny, but critical, hair-like structures called cilia on cell surfaces. The discovery has important implications for human health because lack of cilia can lead to serious diseases such as polycystic kidney disease, blindness and neurological disorders.

"If we want to better understand and treat diseases related to cilium development, we need to identify important regulators of cilium growth and learn how those regulators function," said co-author Aimin Liu, associate professor of biology at Penn State. "This work gives us significant insight into one of the earliest steps in cilium formation."

The researchers describe their findings in a paper that will be published online in the Proceedings of the National Academy of Sciences during the week of 27 January 2014. In addition to Liu, authors include Penn State cellular biologists Xuan Ye, Huiqing Zeng and Gang Ning, as well as Jeremy F. Reiter, a biophysicist at the University of California - San Francisco.

Cilia, which are present on the surface of almost all mammalian cells, are responsible for sending, receiving, and processing information within the body. "You could think of cilia as the cells' antennae," Liu said. "Without cilia, the cells can't sense what's going on around them, and they can't communicate." Cilia also perform important filtering and cleansing functions. For example, cilia inside the trachea, or windpipe, trap and prevent bacteria from entering the lungs.

In a previous study, Liu and his colleagues learned that a protein called C2cd3 is important for cilium formation because mice that lacked this protein exhibited severe developmental problems typically associated with the lack of cilia. "At the time we knew only that if we get rid of the protein, the cells in the animal would not grow cilia," Liu said. "We didn't understand why, but now we do."

A cilium grows from a centriole, a structure that clings to the inner surface of the cell and serves as an anchor for the cilium. Before a cell can grow a cilium, it needs to assemble a set of appendages at one end of the centriole. These appendages can then connect the centriole to the cell surface, allowing the outgrowth of a cilium. Just how these appendages are assembled, though, remained a mystery for more than four decades since their discovery in 1962. Liu and his colleagues found that appendages were not assembled at the end of the centriole when the C2cd3 protein is not present. As a result, the centriole is not associated with the cell membrane and cannot recruit other proteins for the further growth of the cilium. "So our protein is required for the very first step of putting a cilium together," Liu explained. "Without those appendages, the cilium growth cannot happen."

The researchers hope their discovery will lead to greater knowledge of the process of cilium development and, eventually, to treatments for a wide range of health problems that fall under the label of ciliopathy. "Ciliopathy is a scientific term that covers a lot of diseases," Liu said. As well as contributing to cystic disorders in the kidney and liver, lack of cilia can lead to blindness or deafness, since cilia in the retina serve as receptors that process light stimulation and cilia within the ear are required in neurons that translate sound waves into neural signals.


'/>"/>

Contact: Barbara K. Kennedy
sciencew@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Related medicine news :

1. Need for Mosquito Control Becoming More Critical
2. Life Insurance To Cover Funeral Costs Or Critical Illness Plans? What Should Seniors Choose?
3. Is Critical Bench Program The Effective Solution For Building Muscle? – Vinamy
4. Critical Bench: Review Exposes Mike Westerdal’s Muscle and Strength Building Program
5. Middle East Critical Infrastructure Protection (CIP) Market (Technology, Solutions, Services) Worth $13.07 Billion by 2018 - New Report by MarketsandMarkets
6. Human neural stem cells could meet the clinical problem of critical limb ischemia
7. UC Irvine Health Appoints William C. Wilson, MD, as Director of Critical Care Services
8. Global Food Exchange Responds to Critical Need in the Philippines
9. UC Irvine Health Appoints William C. Wilson, MD, as Hospital Director of Critical Care Services, Division of the Department of Anesthesiology & Perioperative Care
10. Discover Innovative Upper Body Exercises With The “Critical Bench” Course – Vkoolelite
11. Critical Care Medicine Expert from The Children’s Hospital of Philadelphia Receives Distinguished Career Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Critical protein discovered for healthy cell growth in mammals
(Date:2/13/2016)... (PRWEB) , ... February 13, 2016 , ... In the ... forward. They’ll groom themselves to perfection, go out of their way to be romantic, ... – just take a look at any online dating profile. , A recent ...
(Date:2/12/2016)... , ... February 12, 2016 , ... According to an ... are beginning to account for a significant portion of hernia repairs throughout the United ... the Beverly Hills Hernia Center notes that this trend has not only been expected, ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & ... purpose of these scholarships is to encourage applicants to pursue a degree in their ... these two parishes. , “We have available jobs in St. Landry and Evangeline ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... South Florida’s philanthropic community at its 10th anniversary Fashion Luncheon on Monday, February ...
(Date:2/12/2016)... ... 12, 2016 , ... Fixed Dose Combination Drug Development: , ... http://www.fdanews.com/fixeddosecombination , Fixed dose combination products are a ... from all stakeholders in the development of new chemical entities. , However, the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... N.J. , Feb. 12, 2016  Innophos Holdings, Inc. ... and nutritional specialty ingredients, today announced that it will host ... 10:00 am ET to discuss its fourth quarter and full ... --> The press release detailing fourth quarter and full ... after market close. --> ...
(Date:2/12/2016)... Inc., a medical device company that pioneered the use of the ... device indicated for fusion for certain disorders of the sacroiliac (SI) ... Contractor (MAC) covering the states of Connecticut , ... Massachusetts , Minnesota , ... Rhode Island , Vermont and ...
(Date:2/12/2016)... 12, 2016 On Thursday, Feb. 11, 2016, ... St. David,s North Austin Medical Center successfully completed the ... Xi ® Surgical System with Trumpf Medical,s advanced ... Thiru Lakshman , M.D., colorectal surgeon at the Texas ... Integrated Table Motion technology, which seamlessly combines the da ...
Breaking Medicine Technology: