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Criteria based on CT imaging after chemotherapy may help predict survival
Date:12/1/2009

ined margins into homogeneous lesions with sharp borders. These criteria were validated with a separate group of 82 patients with unresectable (unable to be removed by surgery) colorectal liver metastases treated with bevacizumab-containing chemotherapy.

The researchers found that "morphologic criteria correlated strongly with the percentage of residual tumor cells and also with pathologic response stratified as complete, major, or minor using 50 percent residual tumor cells as the cutoff value between major and minor pathologic response. Optimal morphologic response to preoperative therapy translated into a survival benefit after hepatic resection. In a separate validation cohort of patients with unresectable colorectal liver metastases, response by morphologic criteria was also associated with improved overall survival."

The authors add that although the sample size in the surgical group was small, "these results highlight the importance of response rather than baseline clinical factors in determining patient outcome after liver resection."

" our results indicate that morphologic response may be a useful, noninvasive surrogate marker of pathologic response and improved survival in patients with colorectal liver metastases receiving a bevacizumab-containing regimen. It provides complementary information to traditional size-based criteria in assessing CT response to bevacizumab in colorectal liver metastases."


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Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
JAMA and Archives Journals
Source:Eurekalert

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