Navigation Links
'Crime Boss' Gene May Spur Breast Cancer
Date:3/12/2008

Finding might explain why some tumors are aggressive and spread, researchers say

WEDNESDAY, March 12 (HealthDay News) -- Scientists have identified a gene they say can promote aggressive breast cancer by acting as a kind of "crime boss," capable of changing the behavior of more than 1,000 genes within tumor cells.

So far, the research has been limited to mice. But if the finding holds true in planned human studies, it may help doctors predict which breast cancers are likely to be aggressive and spread, said Terumi Kohwi-Shigematsu, a senior scientist at the Lawrence Berkeley National Laboratory at the University of California, Berkeley. She is the corresponding author of the study along with her husband, fellow researcher Yoshinori Kohwi, who's also with the Berkeley laboratory.

The gene, SATB1, "is a regulator of whether the cancer spreads," Kohwi-Shigematsu said. "SATB1 was cloned by us [at the Berkeley lab] in 1992. The gene is already known to be expressed in activated T-cells in animals as part of the immune system response."

SATB1's normal roll in the cell is to "organize" other genes. But when SATB1 is overactivated, the legions of growth-promoting genes that it regulates can run amok, Terumi Kohwi-Shigematsu explained.

Now, the researchers have pinpointed it as the gene that can promote aggressive breast cancer. "SATB1 is a genome organizer, which allows a global change in gene expressions," Kohwi-Shigematsu said. "When it is expressed in breast cancer cells, the cells acquire metastatic activity and growth advantage."

"Once it is expressed," she added, "cancer will spread." Conversely, if SATB1 is silent, cancer doesn't grow.

For the research, the study authors took an established line of breast cancer cells and injected them into laboratory mice. When the scientists disrupted the SATB1 and stopped the expression of the SATB1 protein from the gene, the cancer cells stopped gr
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. ViewPoint Bank Funds Senior Crimestoppers Program at Meadows Health and Rehab Center in Dallas
2. COX-2 expression is marker for cancer development in some benign breast biopsies
3. Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer
4. Late treatment with letrozole can reduce breast cancer recurrence risk
5. Cardiac effects associated with breast cancer treatment appear lower with dose-dense chemotherapy
6. Yoga Eases Menopause Symptoms in Breast Cancer Survivors
7. Drugs like aspirin could reduce breast cancer and help existing sufferers
8. Estrogen Levels in Blood Predict Breast Cancers Return
9. The Pennsylvania Breast Cancer Coalition Announces Last Chance to Enter Makeover for Mom Contest
10. New revelations in epigenetic control shed light on breast cancer
11. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Crime Boss' Gene May Spur Breast Cancer
(Date:6/2/2015)... FDA approved Orlistat for weight loss ... satisfactory doctor consultation. The less potent, over-the-counter version of Orlistat, ... has the longest track record as an FDA approved weight ... down fats in foods, Orlistat treatment prevents the body from ... be excreted through feces. , The most common ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Thermi, ... technology company has successfully transitioned into its new ... due to the company’s continued rapid worldwide expansion ... comprised of over 25 Thermi employees, including those ... development teams. , “As one of the fastest ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 While the ... adaptions of comic books, comic books themselves are stepping ... Comics Uniting Nations plans to produce educational comics in ... Global Goals for Sustainable Development - an international effort ... poverty, hunger, health, education, sustainable energy, inequality, climate change ...
(Date:6/2/2015)... SB 277 (CA Legislature, bit.ly/1Q0P8OY) will require ... public or private school. SB277 cleared three Senate policy ... Committee (Sacramento Bee, May 11, 2015, bit.ly/1Gh9jU7). It passed ... “We believe that this bill affects the education of ... will (the) affect public health of California.. It is ...
(Date:6/2/2015)... “We want men to realize the importance of protecting ... Phillips, owner of SunGrubbies.com, “that is why we offer ... that work well for outdoor activities.” , The effects of ... can take up to thirty years to develop. The ... cancer to occur. That is why the simple act ...
Breaking Medicine News(10 mins):Health News:Diet Doc Adds FDA Approved Orlistat to their Medically Supervised Diet Plans, Offering Their Patients another Option for Trimming Fat from the Hard to Reach Areas 2Health News:Diet Doc Adds FDA Approved Orlistat to their Medically Supervised Diet Plans, Offering Their Patients another Option for Trimming Fat from the Hard to Reach Areas 3Health News:Diet Doc Adds FDA Approved Orlistat to their Medically Supervised Diet Plans, Offering Their Patients another Option for Trimming Fat from the Hard to Reach Areas 4Health News:Thermi Moves to New Corporate Headquarters as Rapid Company Expansion Continues 2Health News:Can Comics Help the United Nations Save the World? 2Health News:Can Comics Help the United Nations Save the World? 3Health News:A Voice For Choice Releases A Statement As SB277 Is Referred To Single Assembly Committee And Bypasses Education and Judicial Scrutiny 2Health News:It is Time to Show Father Who Knows Best, Says SunGrubbies.com, a Leading Online Sun Protection Retailer 2
... Md., Aug. 12 The third annual Psoriasis Cure Now ... a theme of helping psoriasis patients connect with one another. ... patients to resist the social isolation that often results from ... with psoriasis and psoriatic arthritis to provide mutual support and ...
... French . , Montreal, August 12, 2009 Sounds ... according to a new Canadian study. In the online edition of ... PNAS ), scientists from the Universit de Montral and the Montreal ... in the brain allows people to distinguish between different types of ...
... ... of device, new trials , ... San Diego, CA (PRWEB) August 12, 2009 -- OcumatRx, an early stage ... permanent treatment of patients with Glaucoma, has announced the successful completion of clinical trials ...
... , , Milestone shows ... shows how much the culture has changed when reporting medical events , ... Safety Authority has collected over one million reports from Pennsylvania healthcare facilities ... events that did not cause harm to the patient. , , ...
... Hard to Treat Diseases (HTDS.PK) www.htdsmedical.com - ... 2009 http://www.pinksheets.com/pink/quote/quote.jsp?symbol=htds today at 10:30AM EST that ... correct the ownership of its intellectual property (IP) rights. ... five (5) issued patents, HTDS finds that the Company ...
... ROCHESTER, N.Y., Aug. 12 VirtualScopics, Inc. (Nasdaq: VSCP ... financial results for the quarter and six months ended June 30, 2009. ... Revenues for the second quarter of 2009 increased 47% to $2.5 million, compared ... Gross profit for the second quarter of 2009 increased 96% to $1.4 ...
Cached Medicine News:Health News:Psoriasis Video Contest Launched to Encourage Psoriasis Patients to Connect and Collaborate 2Health News:Human mind: Sound and vision wired through same 'black box' 2Health News:OcumatRx Announces Promising Clinical Trial Results for Implant with Potential to Permanently Treat Glaucoma 2Health News:OcumatRx Announces Promising Clinical Trial Results for Implant with Potential to Permanently Treat Glaucoma 3Health News:Pennsylvania Patient Safety Authority Marks Milestone With One Million Reports 2Health News:Pennsylvania Patient Safety Authority Marks Milestone With One Million Reports 3Health News:Pennsylvania Patient Safety Authority Marks Milestone With One Million Reports 4Health News:Hard To Treat Diseases (HTDS.PK) Completes IP Ownership Filings With U.S. Patent and Trademark Office 2Health News:Hard To Treat Diseases (HTDS.PK) Completes IP Ownership Filings With U.S. Patent and Trademark Office 3Health News:Hard To Treat Diseases (HTDS.PK) Completes IP Ownership Filings With U.S. Patent and Trademark Office 4Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 2Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 3Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 4Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 5Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 6Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 7Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 8Health News:VirtualScopics, Inc. Reports a Record Breaking Quarter 9
(Date:6/1/2015)... June 1, 2015 NSHOA Cancer Center ... today announced positive, top-line results from its recently ... efficacy and safety of the Company,s 5-HT 3 ... (granisetron injection, extended release) as part of a ... 1 ) receptor antagonist fosaprepitant and the IV ...
(Date:6/1/2015)... , June 1, 2015 Researchers from ... Case Western Reserve University School of Medicine will present ... a potential novel combination treatment for cancer patients with ... mutations in small cell lung cancer (SCLC), at the ... Annual Meeting in Chicago . ...
(Date:6/1/2015)... 1, 2015   OTC Markets Group Inc. ... Connected financial marketplaces for 10,000 U.S. and global ... San Diego -based biopharmaceutical company, on its ... only public venture market for entrepreneurial and development ... "We,re happy to congratulate ...
Breaking Medicine Technology:New cancer therapy study results - MAGIC Trial 2UH Case Medical Center Experts to Present Data at 51st ASCO Annual Meeting 2UH Case Medical Center Experts to Present Data at 51st ASCO Annual Meeting 3OTC Markets Group Congratulates OncoSec Medical on NASDAQ Listing 2
... of the Criterion precast gel system, allows you ... a single run. Criterion gels are wider and ... mini gel. They accommodate Bio-Rad's 11 cm ReadyStrip ... of separation and speed in 2-D electrophoretic applications. ...
... Mini-Vertical Gel System simplifies the process of separating ... It is able to run four gels at ... maximize utility and throughput, the 120 mini-vertical runs ... (W x L) at one time. The 120 ...
... High-Throughput (HTP) Protein Electrophoresis ... integrated pre-cast gel system ... protein analysis. It consists ... E-Base™ integrated power device, ...
... agarose gel electrophoresis into an automated, high-throughput ... bufferless, pre-cast system is ideal for analyzing ... and more. Fully automated, robot-compatible, and ready ... system makes your high-throughput screening assignments as ...
Medicine Products: