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Crescendo Bioscience to present multiple studies at 2014 EULAR Meeting
Date:6/10/2014

the Annals of Rheumatic Disease, further validate the finding that low/high scores of Vectra DA are associated with less/more joint damage over time.

Title: In early RA patients with non-response to methotrexate the change in multi-biomarker disease activity score is differentially associated with subsequent response to non-biological versus biological therapy.
Presenter: Karen Hambardzumyan
Date: June 13, 2014; 11:45 AM; Poster Area D, Level 4
Key Finding: This SWEFOT study suggests that changes in the Vectra DA score may help guide subsequent therapy. In DMARD-nave patients who had inadequate responses to 3 months of methotrexate, the changes in Vectra DA score at month 3 were associated with the likelihood of having a subsequent response to either anti-TNF or triple (DMARD) therapy.

Title: Validation of a multi-biomarker disease activity score in rheumatoid arthritis in relation to imaging inflammation and damage.
Presenter: Simon Krabbe
Date: June 13, 2014; 11:45 AM, Poster Area D, Level 4
Key Finding: Vectra DA correlated with imaging measures of joint inflammation and joint damage, providing further evidence that the test is associated with biological processes of disease in RA joints.

Title: Residual inflammatory activity assessed by a multi-biomarker disease activity blood test is linked to structural damage in RA patients in low disease activity/remission and normal C-reactivity protein level.
Presenter: Georg Schett
Date: June 12, 2014; 11:45 AM, Poster Area D, Level 4
Key Finding: In RA patients who were in clinical remission or low clinical disease activity, Vectra DA was found to correlate with erosive damage in joints, as detected by imaging with high-resolution CT scanning, suggesting that the inflammatory mediators measured by Vectra DA are linked to structural bone damage in RA.

Title: Effects of tofacitinib treatment on leptin and other components of the
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Contact: Ronald Rogers
rrogers@myriad.com
801-584-3065
Myriad Genetics, Inc.
Source:Eurekalert

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