Navigation Links
Course of West Nile Infection Charted
Date:3/18/2009

Scientists found levels of certain cytokines spiked during disease stage

WEDNESDAY, March 18 (HealthDay News) -- Scientists in South Africa recently had the rare opportunity to follow the West Nile virus from initial infection through symptoms and recovery in a 29-year-old lab worker who had accidentally jabbed herself with an infected needle.

In particular, the researchers followed the trajectory of cytokines, a type of signaling molecule in the body, as the patient progressed through the illness.

"There are currently no specific treatments for neurological West Nile virus infections," said Marietjie Venter, head of the respiratory and emerging neurological virus program in the department of medical virology at the University of Pretoria in South Africa and co-author of a letter in the March 19 issue of the New England Journal of Medicine. "Cytokines may serve as potential targets for treatment," Venter said.

Another expert said the importance of the report lies more in the basic science knowledge it provides for West Nile, which has been endemic in North America since its first appearance in 1999.

"They were able to link the course of the infection to basic science," said Dr. Pascal James Imperato, dean and distinguished service professor at State University of New York (SUNY) Downstate Medical Center in New York City. "The interest here lies in the range of cytokines which were produced and the levels at which they were produced at different points of time."

People infected with West Nile, which is typically passed from birds to mosquitoes to humans, can experience a range of symptoms, from mild, flu-like aches and pains to life-threatening encephalitis (inflammation of the brain).

These researchers, in effect, had the opportunity to carry out a serendipitous controlled trial when the 29-year-old woman, who was HIV-negative, pricked herself with the needle.

The woman's symptoms began one week after the needle mishap and included, at first, backache and stiffness in the neck. This was soon followed by a mild fever and symptoms of meningoencephalitis (inflammation of the brain and surrounding membrane) such as severe headache, sensitivity to light and joint pain.

The symptoms subsided in about three weeks, and the woman had completely recovered by day 26 post-infection.

Blood levels of 16 cytokines were measured on the day of infection and eight subsequent days, including the day of full recovery, and compared to a blood sample taken from the patient five years after her illness.

They found that levels of the cytokines interferon-alpha and interleukin-13, both of which have effects on the immune system, were elevated.

The authors speculated that increased levels of interferon-a might help treat neurological infection from West Nile, because interferon-a has a dampening effect on the inflammatory responses of the body.

According to Venter, two patients with West Nile Virus-related encephalitis had shown improvement when treated with interferon alpha.

"Our study confirms that this cytokine increases to high levels when symptoms became apparent in our patient and supports the use of interferon alpha 2 beta as a treatment," she said. "Other cytokines that have been highlighted in the course of this neurological case that warrant further research for their role in controlling West Nile Virus infection include interferon inducible protein 10 (IP10) and interleukin 13."

"The case study also highlights that this strain of the virus, West Nile virus lineage 2, which is endemic to Southern Africa, may cause severe disease and should be considered as a cause of neurological disease to patients living here and travelers to this area," Venter added. "This contradicts the general belief that West Nile Virus lineage 2 only causes mild disease but rather suggests that it may be an underappreciated cause of neurological infection in Southern Africa."

Also, the patient had received the Yellow Fever vaccine shortly before the accident, suggesting that the vaccine is not protective against West Nile, as had been suspected.

More information

The U.S. Centers for Disease Control and Prevention has more on West Nile virus.



SOURCES: Marietjie Venter, Ph.D., head, respiratory and emerging neurological virus program, department of medical virology, University of Pretoria, South Africa; Pascal James Imperato, M.D., dean, and distinguished service professor, graduate program in public health, State University of New York (SUNY) Downstate Medical Center, New York City; March 19, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research shows how chronic stress worsens neurodegenerative disease course
2. ABQAURP Announces Certificate Course in Medical Error Prevention
3. Speedier skis on course for World Cup glory
4. FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis
5. ABIH Approves Certification Credit for SSPC Training Courses
6. Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication
7. Pursuing parenthood: Discourses of persistence
8. Silverchair Learning Systems Updates and Develops New Courses
9. U.S. Career Institute Launches 1st Ever DETC Accredited Medical Assistant Course
10. Ortho Organizers(R) Announces the Launch of the Ancor Pro(TM) Orthodontic Anchorage System Hands-on Course
11. DRAXIS Announces Application for Normal Course Issuer Bid
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Course of West Nile Infection Charted
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance ... beginning of a new charity campaign. As part of their ongoing community involvement ... In the belief that children deserve a voice, and in the spirit of ...
(Date:2/8/2016)... ... February 08, 2016 , ... If you are feeling that ... you are not alone. According to the Center for Disease Control and Prevention (CDC), ... 2 diabetes and certain types of cancer, some of the leading causes of preventable ...
(Date:2/8/2016)... ... February 08, 2016 , ... Local insurance agency ... Venice, FL area, has initiated a fundraiser for a two year old little ... days after Christmas. To support this beautiful child who is facing life’s journey ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... frequently. While a significant number of women and men with eating disorders report ... itself, that best predicts the development of an eating disorder. , At ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Association of Home ... and the Home Health and Hospice ICD-10 Transition Workgroup are working closely with ... guidance and clarifications, to address concerns over the use of 'A' as the ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... NORRITON, Pa. , Feb. 8, 2016 /PRNewswire/ ... of November Research Group (NRG),s pharmacovigilance technology ... pharmacovigilance system-related consulting services and an Oracle Argus ... compliance services to Life Sciences companies. ... strengthens and expands HighPoint,s life sciences capabilities and ...
(Date:2/8/2016)... Switzerland and PALO ALTO, Calif. , Feb. ... and chemical manufacturing, and Kodiak Sciences Inc., a biopharmaceutical ... of retinal disease, announced today agreements for the clinical ... will manufacture material at multiple sites, including Slough (UK), ... --> --> Retinal diseases, such as ...
(Date:2/8/2016)... 2016  Avista Pharma Solutions ("Avista Pharma") announced today ... Financial Officer (CFO). Mr. Setzer is a finance and ... various roles within growing technology and life science companies. ... Executive Director of Finance at INC Research, a publicly ... . Previously, Mr. Setzer served as CFO of ...
Breaking Medicine Technology: