Navigation Links
Couples with fertility problems where the man is over 35 have increased difficulty in conceiving
Date:7/6/2008

Barcelona, Spain: Pregnancy rates decrease and miscarriages increase when a father is over 35 years of age, a scientist will tell the 24th annual conference of the European Society of Human Reproduction and Embryology tomorrow(Monday 7 July). Dr. Stphanie Belloc, of the Eylau Centre for Assisted Reproduction, Paris, France, will say that this is the first time that such a strong paternal effect on reproductive outcomes has been shown.

Dr. Belloc and colleagues followed up 21239 intrauterine inseminations (IUIs). In IUI the sperm is 'washed', or spun in a centrifuge, in order to separate them from the seminal fluid, and then inserted directly into the uterus. If the sperm are not washed they can cause uterine cramps which can expel the semen because of prostaglandins in the seminal fluid. 12236 couples who had consulted at the Centre between January 2002 and December 2006 were involved, and the husband's semen was used in all cases. In most cases the couples were being treated because of the husband's infertility

The sperm of each partner was examined at the time of the IUI for a number of characteristics, including sperm count, motility and morphology. Clinical pregnancy, miscarriage and delivery rates were also carefully recorded. Detailed analysis of the results allowed the scientists to separate out the male and female factors related to each pregnancy.

Maternal age was closely associated with a decreased pregnancy rate of 8.9% in women over 35 years, compared to 14.5% in younger women. Miscarriage rates were also typically affected by maternal age.

"But we also found that that the age of the father was important in pregnancy rates men over 35 had a negative effect," says Dr. Belloc. "And, perhaps more surprisingly, miscarriage rates increased where the father was over 35."

The effect of maternal age on the ability to conceive and on miscarriage rates is well known, but there is still controversy about the role of the father. Although there are many reports that show an overall decline in sperm counts and quality from decade to decade, up to now there has been no clinical proof that simply being an older man has a direct effect on a couple's fertility.

"We already believed that couples where the man was older took longer to conceive," says Dr. Belloc, "but a number of reasons had been put forward for this. Neither was there any definite evidence that miscarriage rates increased when the man was older. To undertake a complex multivariant statistical analysis of data from a large group of patients was difficult, but we thought it was a question that needed to be answered once and for all. Some recent studies have established a relationship between the results of IUI and DNA damage, which is also correlated to a man's age, suggesting that it might be an important factor, but until now there was no clinical proof."

Even though the numbers in the study are already large, the scientists intend to include more couples in the next few years to confirm their results further. "This research has important implications for couples wanting to start a family," says Dr. Belloc, "and we need to research it in as large a group as possible."

"How DNA damage in older men translates into clinical practice has not been shown up to now," says Dr. Belloc. "Our research proves for the first time that there is a strong paternal age-related effect on IUI outcomes, and this information should be considered by both doctors and patients in assisted reproduction programmes.

"We believe that the use of IVF or ICSI should be suggested to infertile patients where either party is over 35 years of age. In IVF, the zona pellucida (the outer membrane of the egg) seems to be an efficient barrier in preventing the penetration of sperm with DNA damage, and in ICSI, the best sperm can be selected out for use. These methods, although not in themselves a guarantee of success, may help couples where the man is older to achieve a pregnancy more quickly, and also reduce the risk of miscarriage," she says.


'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Infertility Consultancy and Chicago Pharmacy Bring Hope to Infertile Couples
2. When couples face the diagnosis of cancer, women carry a larger emotional burden than men
3. Same-Sex Couples Just as Committed as Heterosexual Counterparts
4. Equal level of commitment and relationship satisfaction found among gay and heterosexual couples
5. Helping Couples Fight Prostate Cancer, This Week on Your Cancer Today(TM)
6. New Survey Reveals That Couples Want Vacation Time Together After the Stressful Holiday Season
7. Updated: National Infertility Awareness Week Nov. 4-10; Infertility Affects Significant Number of Couples
8. Couples attending counseling sessions together better prepared to ease childrens concerns
9. Couples more likely to divorce if spouse develops cervical or testicular cancer
10. New photo op for ovaries may solve some mysteries of infertility
11. Leading Fertility Center Adds New Physician
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... as one of the best small businesses for new dads by Fatherly, the digital ... businesses providing progressive benefits to new parents on the organization’s 2016 Best Places ...
(Date:5/27/2016)... ... ... This campaign aims to provide a path to improved education and awareness ... change. , As nearly 795,000 Americans suffering from a new or recurrent stoke each ... an estimated 129,000 of these people dying from stroke, it’s become our nation’s fifth-leading ...
(Date:5/27/2016)... Texas (PRWEB) , ... May 27, 2016 , ... ... satisfying Army body fat composition regulations. This is the first time that Coolsculpting ... normally screened at least every six months to ensure they meet the prescribed body-fat ...
(Date:5/27/2016)... ... 2016 , ... Each year Standard Process Inc. ... this year’s Life University winner of a $2,500 scholarship from Standard ... Awards ceremony. , Outerbridge is approaching her last quarter at Life University in ...
(Date:5/26/2016)... ... 26, 2016 , ... There are many ways to cook a hot dog, ... that Americans prefer their dogs straight off the grill. Of the 90 percent of ... way to cook a hot dog, far outpacing other cooking methods such as steaming ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... Amarantus BioScience Holdings, Inc. (OTCQX: AMBS), ... and Orphan Diseases, today announced that President & CEO Gerald ... SeeThru Equity MicroCap Conference   Where: ... , NY When: Tuesday, May 31 st , ... Where: Grand Hyatt Hotel, 109 East 42 nd St, ...
(Date:5/26/2016)... 2016   Change Healthcare , a ... solutions and technology-enabled services designed to enable ... a strategic channel partnership with SourceMed, the ... and revenue cycle management services that empower ... clinics to optimize revenue, operational efficiency and ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May ... QGEN ; Frankfurt Prime Standard: QIA) today announced that ... with Therawis Diagnostics GmbH to develop and commercialize predictive assays ... market PITX2 as a marker to predict effectiveness of anthracycline ... "We are pleased to partner with Therawis, which ...
Breaking Medicine Technology: