Navigation Links
Could targeting a virus treat a common pediatric brain tumor?
Date:9/26/2011

Medulloblastomas are the most common cancerous (malignant) brain tumors in children. Although survival rates have improved over the years, medulloblastoma remains associated with substantial mortality, and long-term survivors often suffer debilitating effects from the intensive treatments. A team of researchers, led by Cecilia Sderberg-Nauclr and John Inge Johnsen, at the Karolinska Institutet, Sweden, has now identified a potential target for a more cancer-specific approach to treating medulloblastoma that they hope could improve patient outcome.

Sderberg-Nauclr, Johnsen, and colleagues found that a large proportion of primary medulloblastomas and medulloblastoma cell lines are infected with a virus known as human cytomegalovirus (HCMV). Furthermore, the majority of primary medulloblastomas expressed HCMV proteins. Importantly, the antiviral drug valganciclovir reduced human medulloblastoma tumor cell growth both in vitro and upon xenotransplantation in mice. Targeting a protein (COX-2) in the cancer cells, expression of which was found to be induced by the HCMV, had similar in vitro and in vivo effects. The authors therefore suggest that targeting HCMV and/or COX-2 could provide a new therapeutic approach to treating individuals with medulloblastoma.

In an accompanying commentary, Cynthia Hawkins and Sidney Croul, discuss in detail the concept that it could be possible to exploit the presence of HCMV to target medulloblastomas therapeutically. They also note that this approach might be applicable to other brain tumors, as several viruses have been linked to a range of brain tumors, including medulloblastomas, gliomas, and choroid plexus papillomas.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
3. Tiny fruit fly could offer big clues in fight against obesity, researcher says
4. New Book Reveals How Qigong Could Be The Eastern Answer To Botox
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Charging less for more effective treatments could reduce health care costs while improving health
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
9. Most maternal deaths in sub-Saharan Africa could be avoided
10. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
11. New Technology Could Widen Reach of Vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... 2015 , ... This week Northeast Nebraska Imaging, Norfolk’s leading ... website’s goal is to provide patients with detailed information about the various aspects ... online. , Part of the center’s rebranding efforts, the website was designed specifically ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... two firms have merged to form Camber Collective. Camber Collective provides strategic ... merger combines SwitchPoint’s strategy consulting expertise with Hope Consulting’s deep experience in ...
(Date:7/7/2015)... NY (PRWEB) , ... July 07, 2015 , ... ... email newsletter and website that helps active people find the most fun activities to ... active lifestyle coverage for millennials. It also increases Greatist’s opportunity for events, e-commerce, and ...
(Date:7/7/2015)... ... July 07, 2015 , ... Quadrino Law Group is pleased to ... Melville, New York 11747. The new facility is a state of the art ... , Richard Quadrino, the firm's CEO and founder, said, "We are pleased to service ...
(Date:7/7/2015)... ... July 07, 2015 , ... SC&H Group, a leading audit, tax, and consulting ... to the community through company-wide volunteering efforts. , On an annual basis, in coordination ... assisting those in need throughout Baltimore and Washington D.C. , This year, ...
Breaking Medicine News(10 mins):Health News:Northeast Nebraska Imaging Launches New Patient Friendly Website 2Health News:SwitchPoint and Hope Consulting Have Merged to Form Camber Collective 2Health News:Greatist Acquires Active Lifestyle Brand Blood, Sweat & Cheers 2Health News:SC&H Group Celebrates 9th Annual Day of Service 2
... , PRINCETON, N.J., Aug. 5 Novo ... announced the appointment of Per Falk, M.D., Ph.D., as vice ... Dr. Falk joins the U.S. Executive Team and will report ... Novo Nordisk U.S. affiliate, and senior vice president for Novo ...
... , CARLSBAD, Calif., Aug. 5 GenVault ... is enabling independent groups, from diverse research areas, to recover DNA ... and Illumina iSelect based genotyping. , , Two ... and BMC Genetics 2009, 10 :38 (22 July 2009) ...
... YORK, MONTREAL, and SAN DIEGO, Aug. 5 /PRNewswire-FirstCall/ - ICBS Ltd., (OTCPK: ... on the pharmaceutical market through its subsidiary, Canadian Bio Med Systems Ltd., ... of Quebec. , , , ... High Interest in a New Approach, , ...
... for-profit residences, review finds , WEDNESDAY, Aug. 5 (HealthDay ... for-profit facilities, say Canadian researchers who reviewed the results ... studies found that non-profit nursing homes provided significantly better ... delivered better care. The remaining studies had mixed results. ...
... , , , , ... TrinityCare Senior Living, Inc. (OTC Bulletin Board: TCSR), which develops, manages ... a funding agreement with a national lender for the development of ... Funding for Trinity Woods , an 82-unit, $10 million ...
... NASHVILLE, Tenn., Aug. 5 Emdeon, a leader in revenue ... its first major customer following the recent acquisition of The ... fraud and abuse management services, was acquired by Emdeon on ... Sentinel Group acquisition expanded Emdeon,s portfolio of offerings to help ...
Cached Medicine News:Health News:Novo Nordisk Appoints Per Falk, M.D., Ph.D., as Vice President for Clinical, Medical and Regulatory Affairs for North America 2Health News:GenVault's GenSolve(TM) Reagents Enable State-of-the-Art Genomic Analysis of Dried Blood Spots 2Health News:GenVault's GenSolve(TM) Reagents Enable State-of-the-Art Genomic Analysis of Dried Blood Spots 3Health News:ICBS to focus on pharmaceutical and environmental markets 2Health News:Not-For-Profit Nursing Homes Fare Better in Studies 2Health News:TrinityCare Senior Living Announces Further Expansion in Houston Area 2Health News:TrinityCare Senior Living Announces Further Expansion in Houston Area 3Health News:Emdeon Closes The Sentinel Group Acquisition, Implements First Customer in Less than 30 Days 2Health News:Emdeon Closes The Sentinel Group Acquisition, Implements First Customer in Less than 30 Days 3Health News:Emdeon Closes The Sentinel Group Acquisition, Implements First Customer in Less than 30 Days 4
(Date:7/7/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/rt3mhz/deciphering ... "Deciphering Global Major Pharmaceutical Companies, New Outsourcing Demands ... It has been publicly recognized that global ... series of challenges in the recent years. The ... in small molecule product manufacturing; increasingly challenging process ...
(Date:7/7/2015)... 7, 2015   Decision Resources Group ... dialysis patient management in the U.S. versus the ... U.S. and EU5 nephrologists from approximately 1,870 dialysis ... the most commonly used renal medications in dialysis ... considerably between the two regions.      Other ...
(Date:7/7/2015)... BANGALORE , July 7, 2015 ... innovative clinical trial data management solutions, has been featured ... publication named " EDC and eCOA / ePRO Market ... is one of the leading providers of research and ... 22 EDC and eCOA / ePRO tools in the ...
Breaking Medicine Technology:Deciphering Global Major Pharmaceutical Companies - New Outsourcing Demands and Strategies 2Deciphering Global Major Pharmaceutical Companies - New Outsourcing Demands and Strategies 3Similarities And Differences Exist When Comparing U.S. Versus EU5 Dialysis Patient Management 2Similarities And Differences Exist When Comparing U.S. Versus EU5 Dialysis Patient Management 3Acceliant Ranked Highest in 'Overall Satisfaction' Amongst EDC Providers in ISR Reports' Recent Research 2Acceliant Ranked Highest in 'Overall Satisfaction' Amongst EDC Providers in ISR Reports' Recent Research 3
... Minimally Invasive Surgery Symposium (MISS) will include discussion of ... surgery, single-port bariatric surgery, transoral gastroplasty, and other "frontier" ... by MISS Executive Director Philip R Schauer, MD, on ... , The five-day CME conference, which will be held ...
... Oct. 27 Endologix, Inc. (Nasdaq: ... disorders, today announced financial results for the three and ... McDermott, Endologix President and Chief Executive Officer, said, "Our ... sales of new products by our domestic sales force ...
Cached Medicine Technology:Internationally Renowned Bariatric and Laparoscopic Surgeons To Meet in San Diego 2Endologix Reports 47% Third Quarter 2009 Revenue Growth 2Endologix Reports 47% Third Quarter 2009 Revenue Growth 3Endologix Reports 47% Third Quarter 2009 Revenue Growth 4Endologix Reports 47% Third Quarter 2009 Revenue Growth 5Endologix Reports 47% Third Quarter 2009 Revenue Growth 6Endologix Reports 47% Third Quarter 2009 Revenue Growth 7Endologix Reports 47% Third Quarter 2009 Revenue Growth 8
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: