Navigation Links
Could targeting a virus treat a common pediatric brain tumor?
Date:9/26/2011

Medulloblastomas are the most common cancerous (malignant) brain tumors in children. Although survival rates have improved over the years, medulloblastoma remains associated with substantial mortality, and long-term survivors often suffer debilitating effects from the intensive treatments. A team of researchers, led by Cecilia Sderberg-Nauclr and John Inge Johnsen, at the Karolinska Institutet, Sweden, has now identified a potential target for a more cancer-specific approach to treating medulloblastoma that they hope could improve patient outcome.

Sderberg-Nauclr, Johnsen, and colleagues found that a large proportion of primary medulloblastomas and medulloblastoma cell lines are infected with a virus known as human cytomegalovirus (HCMV). Furthermore, the majority of primary medulloblastomas expressed HCMV proteins. Importantly, the antiviral drug valganciclovir reduced human medulloblastoma tumor cell growth both in vitro and upon xenotransplantation in mice. Targeting a protein (COX-2) in the cancer cells, expression of which was found to be induced by the HCMV, had similar in vitro and in vivo effects. The authors therefore suggest that targeting HCMV and/or COX-2 could provide a new therapeutic approach to treating individuals with medulloblastoma.

In an accompanying commentary, Cynthia Hawkins and Sidney Croul, discuss in detail the concept that it could be possible to exploit the presence of HCMV to target medulloblastomas therapeutically. They also note that this approach might be applicable to other brain tumors, as several viruses have been linked to a range of brain tumors, including medulloblastomas, gliomas, and choroid plexus papillomas.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
3. Tiny fruit fly could offer big clues in fight against obesity, researcher says
4. New Book Reveals How Qigong Could Be The Eastern Answer To Botox
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Charging less for more effective treatments could reduce health care costs while improving health
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
9. Most maternal deaths in sub-Saharan Africa could be avoided
10. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
11. New Technology Could Widen Reach of Vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Water NSW (New South ... manage and distribute imagery, LiDAR, and Elevation Data within ... driest continents on earth, and the need to ensure ... erratic seasonal rainfalls has driven the development of several ... manages raw water supplies for NSW, including high quality ...
(Date:5/6/2015)... May 06, 2015 The GUARDaHEART Foundation ... Community Resource Exchange with the mission of providing basic ... families in need on Thursday, April 30th. , ... advanced blood test for the early-detection and diagnosis of ... changing advanced medical testing to homeless individuals and families. ...
(Date:5/6/2015)... Francisco, CA (PRWEB) May 06, 2015 ... accelerator program - today announced the latest lineup of ... Innovation Summit . The invitation-only event, scheduled for May ... of senior care executives, consumer technology leaders, investors and ... discuss emerging trends, cultivate partnerships and discover new products ...
(Date:5/6/2015)... (PRWEB) May 06, 2015 Established by ... wellness for the estimated 46 million Americans who suffer ... upon monthly medications to alleviate their symptoms. Medicationdiscountcard.com is ... to save patients money on the costs of these ... are used to treat the pain and inflammation in ...
(Date:5/6/2015)... May 06, 2015 Qualidigm ... Conn., has hired healthcare executive Ann Olson, RN, ... Olson will lead Qualidigm’s growing home healthcare services ... to improve the quality, safety, and cost-effectiveness of ... Qualidigm from Interim HealthCare of North Haven, Inc., ...
Breaking Medicine News(10 mins):Health News:Water NSW Unlocks Imagery and Elevation Data Archive Across the Enterprise using Hexagon Geospatial Solutions 2Health News:Water NSW Unlocks Imagery and Elevation Data Archive Across the Enterprise using Hexagon Geospatial Solutions 3Health News:GUARDaHEART and Starbucks® Collaborate for Impactful Event to Help Homeless Families 2Health News:Aging2.0 Global Innovation Summit Provides Unique Forum to Discover New Technologies and Develop Partnerships in the Senior Care Market 2Health News:Aging2.0 Global Innovation Summit Provides Unique Forum to Discover New Technologies and Develop Partnerships in the Senior Care Market 3Health News:Aging2.0 Global Innovation Summit Provides Unique Forum to Discover New Technologies and Develop Partnerships in the Senior Care Market 4Health News:Medicationdiscountcard.com Provides Access to Drug Coupons for Arthritis Awareness Month 2Health News:Medicationdiscountcard.com Provides Access to Drug Coupons for Arthritis Awareness Month 3Health News:Innovative Healthcare Executive Ann Olson Joins Qualidigm as Principal and Vice President 2Health News:Innovative Healthcare Executive Ann Olson Joins Qualidigm as Principal and Vice President 3
... Niedelman, former deputy associate commissioner for regulatory operations for the ... firm Crowell & Moring LLP as senior consultant ... Group. Niedelman is the firm,s second major hire in recent ... gained Cathy L. Burgess, former associate general counsel for the ...
... Jan. 28 The Savvy Self-Funding,Healthcare Conference and Expo ... discuss creative healthcare options during a June 1-3, 2009,conference ... The conference is unique, as it is designed and ... Karrie Andes, SPHR, Director of Human,Resources, created ...
... while 30% are pre-diabetic, study finds , , WEDNESDAY, Jan. 28 ... diabetes in the United States finds that almost 13 percent ... percent of whom have not been diagnosed. , That,s a ... study, although the percentage of undiagnosed individuals has remained the ...
... in a murder case over 5000 years old. New investigations by ... the chronology of the injuries that Oetzi, the glacier man preserved ... out, for example, that he did in fact only survive the ... a few minutes to a number of hours, but no more ...
... CHICAGO Surgeons at Northwestern Memorial Hospital ... a new micro-laser, which uses light energy in place ... spine tumors. The technique offers greater precision and ... and patient recovery period following surgery. , Surgeons ...
... 28 Eliaz Babaev, Ph.D., D.Sc., co-founder and CEO ... wound care, presented on the fundamentals of ultrasound assisted ... Technology at the Palais des Congres in Paris, France ... of the foremost authorities on low frequency, therapeutic ultrasound ...
Cached Medicine News:Health News:Former FDA Official Steven Niedelman Joins Crowell & Moring Health Care Group 2Health News:Former FDA Official Steven Niedelman Joins Crowell & Moring Health Care Group 3Health News:Employer Designed Self-Insured Healthcare Conference Offers Unique Perspective 2Health News:Diabetes Keeps Rising Among U.S. Adults 2Health News:Diabetes Keeps Rising Among U.S. Adults 3Health News:Oetzi's last days 2Health News:New laser for neurosurgery allows greater precision and efficiency for removal of complex tumors 2Health News:Arobella Medical CEO Speaks at International Wound Care Conference in Paris 2
(Date:5/6/2015)... -- Advanced wound care - assess products, developments, and ... hold for the advanced wound care market? ... revenues to 2025, assessing data, trends, opportunities and prospects ... 115 tables, charts, and graphs covering 12 distinct submarket ... and the future market prospects. You will see financial ...
(Date:5/6/2015)... 6, 2015  TriStar Wellness Solutions(R), Inc. (OTCQB: ... opportunities in the advanced wound care marketplace, announced ... based wholly owned independent subsidiary HemCon Medical ... the National Institutes of Health (NIH) to develop ... able to be delivered by a catheter to ...
(Date:5/6/2015)... , May 6, 2015 Medizone ... of the AsepticSure® Hospital Disinfection System, have recently ... confirm medical instrument sterilization in autoclaves, may also ... kill for hospital room disinfection. Biological ... can directly monitor the lethality of a given ...
Breaking Medicine Technology:Advanced Wound Care Market Forecast 2015-2025: Prospects for Leading Companies in Wound Care Biologics, Moist Wound Care and Wound Care Devices 2Advanced Wound Care Market Forecast 2015-2025: Prospects for Leading Companies in Wound Care Biologics, Moist Wound Care and Wound Care Devices 3Advanced Wound Care Market Forecast 2015-2025: Prospects for Leading Companies in Wound Care Biologics, Moist Wound Care and Wound Care Devices 4Advanced Wound Care Market Forecast 2015-2025: Prospects for Leading Companies in Wound Care Biologics, Moist Wound Care and Wound Care Devices 5Advanced Wound Care Market Forecast 2015-2025: Prospects for Leading Companies in Wound Care Biologics, Moist Wound Care and Wound Care Devices 6Collaboration Between HemCon and OHSU is Awarded Additional NIH Grant with Total Value of $1.1M for the Development of a Transurethral Hemostatic Device 2Collaboration Between HemCon and OHSU is Awarded Additional NIH Grant with Total Value of $1.1M for the Development of a Transurethral Hemostatic Device 3Collaboration Between HemCon and OHSU is Awarded Additional NIH Grant with Total Value of $1.1M for the Development of a Transurethral Hemostatic Device 4Collaboration Between HemCon and OHSU is Awarded Additional NIH Grant with Total Value of $1.1M for the Development of a Transurethral Hemostatic Device 5Hospital Rooms Cleaned to Autoclave Standards 2
... Oct. 12 AvMed Health Plans announced that ... its fully insured members. Co-pays, co-insurance and deductibles will not ... have a benefit plan that does not include immunizations. ... our members and we want to ensure that the H1N1 ...
... DALLAS, Oct. 12 Aprima Medical Software ... health record (EHR) and practice management (PM) systems for ... selected Aprima for its 10-provider practice located in Bend, ... the practice made the decision after a positive experience ...
Cached Medicine Technology:AvMed Covers H1N1 Flu Vaccine For Members 2Aprima's EHR Helps Bend Urology Associates Improve Efficiency, Workflow 2Aprima's EHR Helps Bend Urology Associates Improve Efficiency, Workflow 3
Barraquer needle holder, curved, delicate....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Medium weight bone cutter....
Medicine Products: