Navigation Links
Could targeting a virus treat a common pediatric brain tumor?
Date:9/26/2011

Medulloblastomas are the most common cancerous (malignant) brain tumors in children. Although survival rates have improved over the years, medulloblastoma remains associated with substantial mortality, and long-term survivors often suffer debilitating effects from the intensive treatments. A team of researchers, led by Cecilia Sderberg-Nauclr and John Inge Johnsen, at the Karolinska Institutet, Sweden, has now identified a potential target for a more cancer-specific approach to treating medulloblastoma that they hope could improve patient outcome.

Sderberg-Nauclr, Johnsen, and colleagues found that a large proportion of primary medulloblastomas and medulloblastoma cell lines are infected with a virus known as human cytomegalovirus (HCMV). Furthermore, the majority of primary medulloblastomas expressed HCMV proteins. Importantly, the antiviral drug valganciclovir reduced human medulloblastoma tumor cell growth both in vitro and upon xenotransplantation in mice. Targeting a protein (COX-2) in the cancer cells, expression of which was found to be induced by the HCMV, had similar in vitro and in vivo effects. The authors therefore suggest that targeting HCMV and/or COX-2 could provide a new therapeutic approach to treating individuals with medulloblastoma.

In an accompanying commentary, Cynthia Hawkins and Sidney Croul, discuss in detail the concept that it could be possible to exploit the presence of HCMV to target medulloblastomas therapeutically. They also note that this approach might be applicable to other brain tumors, as several viruses have been linked to a range of brain tumors, including medulloblastomas, gliomas, and choroid plexus papillomas.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
3. Tiny fruit fly could offer big clues in fight against obesity, researcher says
4. New Book Reveals How Qigong Could Be The Eastern Answer To Botox
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Charging less for more effective treatments could reduce health care costs while improving health
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
9. Most maternal deaths in sub-Saharan Africa could be avoided
10. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
11. New Technology Could Widen Reach of Vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... Denver, CO. (PRWEB) , ... August 22, 2017 , ... Each of the past six ... to take attractive pictures of these labels and stickers, demonstrating the variety and creativity of ... great group of label images came in. Now, it's time to announce the winners of ...
(Date:8/22/2017)... ... ... “Wilderness Voices”: a collection of poetry inspired by life on a Kentucky farm and ... Martha McKown, an ordained United Methodist minister with graduate degrees in Religious Education and ... sisters studied High School literature. She loved the early English folk ballads, especially ...
(Date:8/22/2017)... KS (PRWEB) , ... August 22, 2017 , ... TopConsumerReviews.com ... products to fight Fatigue . , As the stress of modern life continually ... up the pace. Constant use of artificial stimulants can trap people in vicious high/low ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... Stevens as a 2017-2018 inductee into its VIP Woman of the Year ... is the nation’s leading networking organization exclusively for professional women, boasting more than ...
(Date:8/21/2017)... ... August 21, 2017 , ... Marathon running has surged ... country. , Outdoor running increases exposure to ultraviolet radiation, a carcinogen that promotes ... melanoma, and only half may be adequately protecting themselves with proper clothing and ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... E.I. Medical Imaging (EIMI) has partnered with ... design the worlds first ultrasound system to be used underwater ... habitat. In preparation for a piece produced by Icon ... Dr. Guttridge approached EIMI with the idea of an underwater ... sharks underwater. EIMI ...
(Date:7/26/2017)... , July 26, 2017 Sancilio Pharmaceuticals ... of our clinical trial evaluating Altemia TM , an ... (SCA) and Sickle Cell Disease (SCD). The SCOT Trial, ... the efficacy and safety of Altemia TM in ... conducted under US IND 125274. ...
(Date:7/25/2017)... CAMBRIDGE, Massachusetts , July 25, 2017 The ... treat rare nervous system diseases, has concluded a worldwide license ... the drug SOM0226 against transthyretin amyloidosis (ATTR). Before this licensing ... in a Phase 2 study conducted in Europe ... the United States ...
Breaking Medicine Technology: