Navigation Links
Could statins be used to fight a deadly viral infection?
Date:2/11/2014

inated from human airways with an experimental drug that targets one of the four proteins made the cells less susceptible to infection. The experimental drug also lowers cholesterol levels in cells, so Bates wondered whether statins could be used to fight a hantavirus infection.

The researchers found that pre-treatment of human airway cells with a generic statin called mevastatin, which lowers cholesterol by a mechanism that does not involve the four proteins they identified, made the human airway cells less susceptible to ANDV infection. They tested both the experimental drug, PF-429242, and mevastatin, and both were effective against hantavirus, as measured by how many cells are infected with and without the drugs.

Bates surmises that statins might be given after a known hantavirus infection, or even prophylactically to exposed individuals.

Although the drug inhibition studies initially used the engineered virus, Bates used ANDV itself in high-containment Biosafety Level (BSL)-3 facilities in the Department of Microbiology at Penn to confirm that the results were true for ANDV as well. The next step is to test cholesterol-lowering drugs in an animal model for ANDV infection, working with collaborators to perform the animal studies in a BSL-4 at a national facility.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Credit card-sized device could analyze biopsy, help diagnose pancreatic cancer in minutes
2. Obesity in men could dictate future colon screenings
3. Could you relationship with your mom increase your childs chances of obesity?
4. Automated system could efficiently identify high-risk osteoporosis patients
5. High-tech whole body scan could improve treatment of bone marrow cancer
6. Certain probiotics could help women lose weight
7. Sports medicine physical of the future could help athletes ESCAPE sudden cardiac death
8. Study could lead to liquid biopsy tests for bladder cancer
9. Prion discovery could help keep deadly brain diseases in check
10. Stem Cells Could Prove Effective in Treating Brittle Bone Disease
11. Cell division discovery could offer fresh insight into cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining the main ... , Auto insurance quotes help many drivers find the ... to call an agent or visit an agency for price ... website: http://autocarinsurancebest.com/ . , Every business who relies heavily ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... A study recently published in ... Medicine & Science in Sports & Exercise shows ... reduce gastrointestinal (GI) problems associated with physical strain ... the double-blind, placebo-controlled study took 10 grams of ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
(Date:1/22/2015)... Colorado (PRWEB) January 22, 2015 Four years since ... Queen – which coincided with the marriage of Avasa & Matthew ... THE ROAD, which is scheduled for release through White Swan Records ... message that there is a sacred path available to all of ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... those who take up the habit , , FRIDAY, May 9 ... in their everyday conversations with peers helps reduce smoking rates, ... study included almost 11,000 students, ages 12 to 13, at ... the schools, certain students were selected to receive training about ...
... May 9 Alseres,Pharmaceuticals, Inc. (Nasdaq: ALSE ... call on Thursday, May 15th, 2008 at 9:00am ... 2008 and discuss other matters related to,the Company., ... access the conference call, please dial 877-795-3649 for ...
... 9 Xmark Opportunity Partners,LLC, the investment manager ... and Xmark JV Investment Partners, LLC, announced,today that ... press release,issued by Genaera Corporation (Nasdaq: GENR ... base compensation, cash incentives to executives, workforce,reduction and ...
... standardization, ... and reduces costs, IRVINE, Calif., May 9 ... of Pulse CO-Oximetry and,Measure-Through-Motion-and-Low-Perfusion Pulse Oximetry, have announced ... Masimo SET pulse oximetry. The New Jersey-based hospital ...
... groups to reach,stricken Myanmar, EVANSTON, Ill., May ... to cyclone ravaged Myanmar, among the first,charities actually ... grassroots,disaster relief organization supported by Rotary clubs around ... volunteers was on the ground Thursday (May,8) preparing ...
... fruits and vegetables reduced brain plaques in mouse experiments ... found in many fruits and vegetables, may be able ... study suggests. , In experiments with mice, two flavonoids ... forms the harmful plaques that build up in the ...
Cached Medicine News:Health News:Training Student Leaders Cuts Peers' Smoking Rates 2Health News:Alseres Pharmaceuticals to Host 2008 First Quarter Conference Call 2Health News:Alseres Pharmaceuticals to Host 2008 First Quarter Conference Call 3Health News:Saint Barnabas Medical Center Converts to Masimo SET Technology - Establishing a Foundation for the Future of Pulse Oximetry 2Health News:Saint Barnabas Medical Center Converts to Masimo SET Technology - Establishing a Foundation for the Future of Pulse Oximetry 3Health News:Saint Barnabas Medical Center Converts to Masimo SET Technology - Establishing a Foundation for the Future of Pulse Oximetry 4Health News:Saint Barnabas Medical Center Converts to Masimo SET Technology - Establishing a Foundation for the Future of Pulse Oximetry 5Health News:Rotary Clubs Provide Emergency Shelters, Supplies to Cyclone Victims 2Health News:Flavonoids May Help Treat Alzheimer's 2Health News:Flavonoids May Help Treat Alzheimer's 3
(Date:1/23/2015)...  The Partnership to Fight Chronic Disease (PFCD) released a public opinion ... a new study analyzing the impact of increased cost sharing on ... working to educate policy makers and the public on the costs ... on how the Iowa healthcare exchange could ...
(Date:1/23/2015)... ATLANTA , Jan. 23, 2015 More than a ... a quarter of those with private insurance, filled a prescription ... to a report in this week,s Morbidity and Mortality Weekly ... health care providers to treat moderate to severe pain.  They ...
(Date:1/23/2015)... Inc., a leader in hand hygiene monitoring, today announced ... subsidiary of Ascendis Health Limited, in Johannesburg, ... of millions of patients around the world are affected ... patient to patient via the unwashed hands of healthcare ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... following letter is being released by CEL-SCI Corporation (NYSE Alternext ... Fellow Shareholders: , I am writing today to provide you ... you on our plans for dealing with the current financial ... a year of meaningful accomplishments which put CEL-SCI in a ...
... Pharmacyclics (Nasdaq: PCYC ) announced today the ... by the principals of Pacific Biopharma Group, Ltd. (PBG), ... People,s Republic of China. The transaction was structured as ... at $0.93/share. Robert Duggan, CEO of Pharmacyclics noted, ...
Cached Medicine Technology:CEL-SCI Corporation Releases Letter to Shareholders 2CEL-SCI Corporation Releases Letter to Shareholders 3CEL-SCI Corporation Releases Letter to Shareholders 4CEL-SCI Corporation Releases Letter to Shareholders 5Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd. 2Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd. 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: