Navigation Links
Could dog food additive prevent disabling chemotherapy side effect?
Date:9/20/2013

uld do that.

Ethoxyquin did so, Hke says, apparently by making the cells resistant to the toxic effects of the Taxol.

Once they identified ethoxyquin's effects, they gave intravenous Taxol to mice, and saw nerves in their paws degenerate in a couple of weeks. But when they gave ethoxyquin to the mice at the same time as the Taxol, it prevented two-thirds of the nerve degeneration, which Hke says would have a big impact on quality of life if the same effects were to occur in humans.

Specifically, Hke and his team discovered that molecules of ethoxyquin were binding to Hsp90, one of the so-called heat shock proteins that cells defensively make more of whenever they are stressed. Hsp90 acts as a cell's quality control officer, determining whether a protein is properly formed before sending it out where it is needed. When ethoxyquin binds to Hsp90, two other proteins ataxin-2 and Sf3b2 can't bind to Hsp90. When they can't bind, the cell senses that these two proteins are flawed, so they are degraded and their levels in the cell diminished.

Hke says his team is not certain why too much of those two proteins appears to have a negative effect on nerves, but reducing their levels clearly appears in their studies to make cells more resistant to Taxol toxicity.

Hke and his colleagues are looking into whether this medication could also make nerves more resistant to damage in peripheral neuropathy caused by HIV and diabetes, two other major causes of the pain. A previous study, Hke says, showed that ataxin-2 may cause degeneration in motor neurons in a rare form of ALS, commonly known as Lou Gehrig's disease, suggesting that ethoxyquin or some version of it might also benefit people with this disorder.

Twenty to 30 million Americans suffer from peripheral neuropathy. Hke says it's a "huge public health issue" that doesn't get much attention because it is not fatal.

Hke's team is hoping to conduct safety studies w
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Red wine, fruit compound could help block fat cell formation
2. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
3. Report says new evidence could tip the balance in aspirin cancer prevention care
4. Climate Change Could Be Tough on Seniors Health: Study
5. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
6. Online Tool Could Diagnose Autism Quickly, Developers Say
7. Codeine After Surgery Could Endanger Certain Kids: Study
8. BMC study shows diverting passengers to elevators could help reduce falls at Logan Airport
9. Discovery could help to develop drugs for organ transplant and cancer patients
10. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
11. Saliva test could dramatically increase detection of oral cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Top10BestSEOHosting.com, a leading review website, has recently announced ... most recommended hosting suppliers for the webmasters worldwide ... , “Don’t waste your time on searching ... hosting companies to you,” the IT manager of ... are the most recommended suppliers for everyone. A ...
(Date:9/20/2014)... Las Vegas, NV (PRWEB) September 21, 2014 ... created by Dr. Kenneth Pullman that is helping thousands ... reverse their diabetes symptoms without shots, pills, or prescriptions ... investigative review. , “There are currently tens of ... with both Type 1 and Type 2 diabetes, and ...
(Date:9/20/2014)... GA (PRWEB) September 20, 2014 David ... 20, 2014. The first poster looked at the clinical ... cardiac cycle for calculating diastolic function. In conjunction with ... end-stage renal disease and normal LVEF by echo (>50%). ... stress protocol, and standard SPECT. Emory Toolbox 4.0 ...
(Date:9/20/2014)... Increases in household, construction and ... treatment volumes. However, government regulations and higher landfill ... According to IBISWorld industry analyst Alen Allday, “over ... at reducing the volume of waste generated, and ... Still, a large proportion of waste generated by ...
(Date:9/20/2014)... 20, 2014 On Monday, September 22, ... pediatric cancer research grant from Hyundai Hope on Wheels ... Children’s Hospital located on 11234 Anderson St., in Loma ... Kimberley Payne, Associate Professor at Loma Linda University and ... leukemia in children. , Loma Linda University ...
Breaking Medicine News(10 mins):Health News:Leading Review Website Top10BestSEOHosting.com Unveils The Best Hosting Suppliers In September 2Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 3Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Loma Linda University Medical Center Receives $250,000 Research Grant From Hyundai Hope On Wheels In Honor Of National Childhood Cancer Awareness Month 2Health News:Loma Linda University Medical Center Receives $250,000 Research Grant From Hyundai Hope On Wheels In Honor Of National Childhood Cancer Awareness Month 3
... American College of Physicians, EHR Partners Program to help physicians more ... impacts. , ... Pasadena, California (PRWEB) April 29, 2009 ... 2009 American College of Physicians, (ACP) EHR Partners Program (EPP). The ...
... in on-demand workforce development and productivity, announced today that Emergency ... and management, has switched to the LearnCenter platform to offer ... , ... (PRWEB) April 29, 2009 ...
... April 29 Minnesota, which has long scored well in ... earning mostly solid "A" and "B" grades for air quality ... fared much more poorly in this year,s report. The ... enacted last year.Three counties, Anoka, Mille Lacs and Wright, each ...
... the Stop Smoking London Seminar. Attendees of the Stop ... withdrawal or weight gain. , ... London, UK April 28, 2009 ... the popular Talk 97.1 Free FM in Southern California, is a former ...
... closely monitor the swine flu outbreak both in Mexico where we ... Since Thursday, PCI staff in San Diego, Washington, DC and ... as we determine our organizational priorities and focus our attention and ... number of people. , , "PCI is ...
... virus infecting humans has not been identified in hogs in the ... , The Centers for Disease Control ... this influenza subtype is present in pigs in the United States or anywhere ... The CDC has also said it has found no evidence to ...
Cached Medicine News:Health News:Prime Clinical Systems Participating in American College of Physician's EHR Partners Program 2Health News:Prime Clinical Systems Participating in American College of Physician's EHR Partners Program 3Health News:Emergency Consultants Inc. switches to Learn.com to deliver Continuing Medical Education (CME) courses to physicians 2Health News:Emergency Consultants Inc. switches to Learn.com to deliver Continuing Medical Education (CME) courses to physicians 3Health News:Renowned Smoking Cessation Expert Launches Popular Stop Smoking Seminar in UK 2Health News:PCI's Response to Swine Flu Evolves to Keep Pace with Emerging Health Threat 2Health News:National Pork Board Provides Facts About the Origin of the Flu Outbreak 2
(Date:9/19/2014)... 19, 2014 Research and Markets has ... Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to ... purposes of this report, the human microbiome market is segmented ... microbiome market is expected to be valued as $294 million ... of 22.3% within the forecast period of 2019-2023. The market ...
(Date:9/19/2014)... , Sept. 19, 2014 UBM Medica ... a leading online community to help oncologists and other ... available regarding the use of targeted therapies and immunotherapies, ... research and treatment.  Every September, ... way to raise awareness about blood cancers—helping to increase ...
(Date:9/19/2014)... 19, 2014  Alere Inc. (NYSE: ALR ... following statement today in support of President Barack ... "As the global leader in rapid diagnostics for infectious ... strategy to address the serious threat of antibiotic resistance. ... Administration on initiatives to promote the development of rapid ...
Breaking Medicine Technology:Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 4Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: