Navigation Links
Could deceased heart attack victims expand donor pool?

Researchers from the U.K. suggest that using organs from donors after circulatory death (DCD) who also suffered a previous cardiac arrest out of the hospital environment could expand the pool of available livers for transplant. Results published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, show that using organs from selected DCD donors with pre-hospital cardiac arrest had no significant impact on graft or transplant recipient survival compared to organs from donors experiencing other cardiovascular death.

Similar to the U.S., the U.K. is impacted by a shortage in available livers for transplantation. The number of patients on the waiting list for liver transplant has steadily risen in the U.K., increasing the use of organs or grafts from donors after circulatory death. According to the National Health Service in the U.K. and the Organ Procurement and Transplantation Network in the U.S., the number of candidates on the waiting list for liver transplant is 494 (as of March 31, 2013) and 15,888 (as of November 10, 2013), respectively.

Guidelines from the British Transplant Society and the US-based Institute of Medicine state that organ donation may continue after five minutes of the absence of heartbeat (asystole). Prior research shows that warm ischemic insult linked to donation after circulatory death may increase early and late post-transplant complications compared to donation following brain death.

"A primary concern in using organs from donors who suffered a heart attack is the extra donor warm ischemia timehow long it takes to retrieve an organ from donors with non-beating hearts until blood supply ceases to circulate through the tissues (cold perfusion)," explains lead author Dr. Paolo Muiesan with Queen Elizabeth Hospital in Birmingham, U.K. "Our study examines outcomes in transplant recipients who received livers from DCDs, who also sustained pre-hospital cardiac arrest versus those that had not sustained pre-hospital cardiac arrest."

The research team reviewed data of livers or grafts transplanted between January 2007 and October 2011, identifying 108 donors after circulatory death26 who suffered pre-hospital cardiac arrest and 82 with other types of injury, such as trauma or stroke eventually leading to being identified as potential DCDs. Donors with pre-hospital cardiac arrest had a median age of 51 years, a body mass index (BMI) of 24.9, intensive care unit stay of 2 days, and "downtime" of 20 minutes.

Analyses indicate that short-term outcomes for transplant recipients were more favorable using organs from donors with pre-hospital cardiac arrest than from other deceased donors. Long-term results show no significant different in graft or transplant recipient survival when using organs from pre- and non-pre-hospital cardiac arrest donors. Overall 30-day, 1-year and 2-year graft survival for all recipients of organs from cardiac death donors was 89%, 84% and 79%, respectively.

"Our transplant unit considers deceased heart attack patients who have liver enzyme levels (transaminases) less than four times the normal range to be suitable donors for liver transplant," concludes Dr. Muiesan. "Including selected DCDs with pre-hospital cardiac arrest could boost the donor pool with no adverse outcomes for liver transplant recipients."


Contact: Dawn Peters

Related medicine news :

1. Red wine, fruit compound could help block fat cell formation
2. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
3. Report says new evidence could tip the balance in aspirin cancer prevention care
4. Climate Change Could Be Tough on Seniors Health: Study
5. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
6. Online Tool Could Diagnose Autism Quickly, Developers Say
7. Codeine After Surgery Could Endanger Certain Kids: Study
8. BMC study shows diverting passengers to elevators could help reduce falls at Logan Airport
9. Discovery could help to develop drugs for organ transplant and cancer patients
10. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
11. Saliva test could dramatically increase detection of oral cancer
Post Your Comments:
(Date:12/1/2015)... ... December 02, 2015 , ... ... Gastrointestinal events and association with initiation of treatment for osteoporosis ”. , As ... of pharmacological treatment in patients diagnosed with osteoporosis. Based on a large US ...
(Date:12/1/2015)... , ... December 01, 2015 , ... According to an ... groups has filed a discrimination claim against the U.S. Department of Health and Human ... Affordable Care Act (ACA) plans are breaking the clause in the law prohibiting the ...
(Date:12/1/2015)... Houston, TX (PRWEB) , ... December 01, 2015 , ... ... owner of Vitenas Cosmetic Surgery, has been named by MedEsthetics magazine as the Best ... best of the best among the many elite aesthetic physicians honored by the industry ...
(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015—Since ... improvements in scientific research and discoveries, leading us to better understand the disease’s ... to those affected by HIV/AIDS. Mediaplanet’s cross-platform edition of “World AIDS Day” provides ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... the United States. Podiatrists are well aware that psychology-based patient non-compliance (disobedience of ... often catastrophic contributors to diseases of the diabetic foot. The American Board ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Va. , Dec. 1, 2015  AccuTEC ... unveiled a new corporate logo and brand identity ... the design and engineering of bladed products where ... --> --> Serving manufacturers ... glass, and auto glass equipment, AccuTEC,s product lines ...
(Date:12/1/2015)... NEW BRUNSWICK, N.J. , Dec. 1, 2015 ... the fight against HIV/AIDS, Johnson & Johnson (NYSE: ... partnerships through its Janssen Pharmaceutical Companies to significantly ... adolescent girls, who make up 74 percent of ... 1 . Announced on World AIDS Day, these ...
(Date:12/1/2015)... New York , December 1, 2015 ... Contraceptive Pills, Contraceptive Injectables, Topical Contraceptives, Male ... Implants, Contraceptive Vaginal Rings, Contraceptive Diaphragms, Contraceptive ... Industry Analysis, Size, Share, Growth, Trends and ... released by Transparency Market Research (TMR).The report ...
Breaking Medicine Technology: