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Could deceased heart attack victims expand donor pool?
Date:11/11/2013

Researchers from the U.K. suggest that using organs from donors after circulatory death (DCD) who also suffered a previous cardiac arrest out of the hospital environment could expand the pool of available livers for transplant. Results published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, show that using organs from selected DCD donors with pre-hospital cardiac arrest had no significant impact on graft or transplant recipient survival compared to organs from donors experiencing other cardiovascular death.

Similar to the U.S., the U.K. is impacted by a shortage in available livers for transplantation. The number of patients on the waiting list for liver transplant has steadily risen in the U.K., increasing the use of organs or grafts from donors after circulatory death. According to the National Health Service in the U.K. and the Organ Procurement and Transplantation Network in the U.S., the number of candidates on the waiting list for liver transplant is 494 (as of March 31, 2013) and 15,888 (as of November 10, 2013), respectively.

Guidelines from the British Transplant Society and the US-based Institute of Medicine state that organ donation may continue after five minutes of the absence of heartbeat (asystole). Prior research shows that warm ischemic insult linked to donation after circulatory death may increase early and late post-transplant complications compared to donation following brain death.

"A primary concern in using organs from donors who suffered a heart attack is the extra donor warm ischemia timehow long it takes to retrieve an organ from donors with non-beating hearts until blood supply ceases to circulate through the tissues (cold perfusion)," explains lead author Dr. Paolo Muiesan with Queen Elizabeth Hospital in Birmingham, U.K. "Our study examines outcomes in transplant recipients who received livers f
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Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

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