Navigation Links
Could an old antidepressant treat sickle cell disease?
Date:2/19/2013

p>"This is the first time that fetal hemoglobin synthesis was re-activated both in human blood cells and in mice to such a high level using a drug, and it demonstrates that once you understand the basic biological mechanism underlying a disease, you can develop drugs to treat it," says Doug Engel, Ph.D., senior author of the study and chair of U-M's Department of Cell & Developmental Biology. "This grew out of an effort to discover the details of how hemoglobin is made during development, not with an immediate focus on curing sickle cell anemia, but just toward understanding it."

Engel credits the dedication and persistence of his team, including a former research assistant professor, Osamu Tanabe, M.D., Ph.D., now at Japan's Tohoku University, U-M postdoctoral fellow, Lihong Shi, Ph.D., first author of the study, and research instructor Shuaiying Cui, Ph.D..

Together, they have identified LSD1's crucial role, and its epigenetic interaction with two nuclear receptors in the nuclei of red blood cell precursors called TR2 and TR4. Working in tandem, they repress the expression of the gene that makes fetal hemoglobin an effect called gene silencing. So, interfering with this repression allows the fetal hemoglobin subunits to be made.

Treatment with TCP caused fetal hemoglobin to be produced at such high abundance that it made up 30 percent of all hemoglobin in cultured human blood cells a finding Engel called "startling." TCP is FDA-approved, though patients taking it need to follow strict dietary guidelines to avoid drug interactions with certain naturally occurring chemicals in some foods.

Boosting healthy hemoglobin

Sickle cell disease occurs when a person or animal inherits two defective copies of a gene that governs the production of the "adult" form of hemoglobin. James Neel, the first chair of the U-M Department of Human Genetics, co-discovered the genetic basis for the disease in the late 1940s.

Pe
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Could a computer on the police beat prevent violence?
2. Indian plant could play key role in death of cancer cells
3. Could Duration of Prostate Cancer Hormone Therapy Be Halved?
4. Low-arsenic rice discovered in Bangladesh could have major health benefits
5. Could A Grill, Skillet or Deep Fryer Become the New Valentine's Day Gift?
6. Breakthrough HIV Technology Could Revolutionize Patient Care in Zimbabwe
7. Drinking Imbalance Could Put Marriage on the Rocks
8. Electronic nicotine delivery systems could help reduce smoking
9. Taking insulin for type 2 diabetes could expose patients to greater risk of health complications
10. Group Therapy: New approach to psychosis treatment could target multiple nervous system receptors
11. Electronic health records could help identify which patients most need ICU resources
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Could an old antidepressant treat sickle cell disease?
(Date:8/30/2014)... Insomnia causes disturbances in every aspect of life. ... developed insomnia and the steps often used to return back ... to the show at this link: Dr. Carol Francis ... 30, and will be podcasted at this link (Click ... DrCarolFrancisTalkRadio.com. , "Insomnia causes countless unrecognized complications. Weight ...
(Date:8/30/2014)... HealthDay Reporter FRIDAY, Aug. ... operated on for broken bones or other orthopedic trauma shops ... Less-educated patients and patients who had used narcotic ... shoppers," said study lead author Dr. Brent Morris, a shoulder ... study suggests that doctors aren,t talking to one another about ...
(Date:8/30/2014)... Hastings and Hastings, a qualified team ... Arizona is pleased to report having saved a client ... among many cases where Hastings and Hastings has tailored ... a greater portion of their settlement or recovery. The ... positive solution for Arizona car accident victims is achievable ...
(Date:8/30/2014)... medication commonly used to treat gout, before and ... potential complications from this type of surgery, but ... effects, according to a study published by ... online to coincide with its presentation at the ... after cardiac surgery include postpericardiotomy syndrome (the occurrence ...
(Date:8/30/2014)... "My niece developed a nighttime fever, and ... her fever might get worse," said an inventor from ... of how she was doing, I developed this monitoring ... monitor a child's temperature. The unit instantly alerts parents ... prompt medical care can be given, which is designed ...
Breaking Medicine News(10 mins):Health News:Sleepless Nights, Exhausting Days, Mental Fog – Relief for Insomnia With Clinical Psychologist Dr. Carol Francis 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 3Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $67,100 On A Settlement Of $610,000 2Health News:Medication shows mixed results in reducing complications from cardiac surgery 2
... updated the NCCN Guidelines for Venous Thromboembolic Disease, which ... (PE), and is a common condition in people with ... graduated compression stockings in prophylaxis and treatment, and a ... May 20 The National Comprehensive Cancer Network (NCCN) ...
... Alliance designed to benefit Californians with medical ... Medical Association (CMA), representing 35,000 physicians in ... the MedicAlert Foundation, the leading nonprofit providing ... teamed up to provide patients living with ...
... counseling also proved cost-effective, study finds , , WEDNESDAY, ... program that promoted exercise, healthy eating and quitting ... to moderate chronic obstructive pulmonary disease (COPD) and ... patients in the study were randomly assigned to ...
... Market is Reflected in Burgeoning Pipeline of More than ... from Decision ResourcesWALTHAM, Mass., May 20 Decision Resources, ... for pharmaceutical and healthcare issues, finds that the launch ... over the next 10 years will drive the type ...
... partnership with Axway to provide innovative solutions ... technologists to address the challenges of implementing ... cost-effective manner.BELLEVUE, Wash., May 20 Edifecs, ... simplification and systems interoperability, and Axway, a ...
... Directors of BD (Becton, Dickinson and Company) (NYSE: ... per common share, payable on June 30, 2009 to holders ... rate is $1.32 per share. About BD BD is ... sells medical devices, instrument systems and reagents. The Company is ...
Cached Medicine News:Health News:NCCN Updates Supportive Care Guidelines for VTE 2Health News:NCCN Updates Supportive Care Guidelines for VTE 3Health News:California Medical Association Joins MedicAlert Foundation to Offer Medical Identification for Members and Patients 2Health News:Healthier Lifestyle Can Cut COPD Symptoms 2Health News:The Launch and Uptake of More Than 20 Novel Drugs Over The Next 10 Years Will Drive $12.5 Billion Growth in the Type 2 Diabetes Market 2Health News:Edifecs(TM) and Axway Announce a Partnership Targeting Innovative HIPAA 5010 Migration Solutions. 2Health News:Edifecs(TM) and Axway Announce a Partnership Targeting Innovative HIPAA 5010 Migration Solutions. 3Health News:Edifecs(TM) and Axway Announce a Partnership Targeting Innovative HIPAA 5010 Migration Solutions. 4
(Date:8/29/2014)... 29, 2014  A Boston Scientific Corporation (NYSE: ... stent removability and preliminary long term stricture resolution ... the August issue of the peer-reviewed journal, Gastroenterology. ... is being conducted in 11 countries and five ... metal stents (FCSEMS) after extended indwell (i.e., up ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014 Medina ... as CEO and member of the Board of Directors ... of medical device development and commercialization experience, including over ... Mr. Engelson previously served as a Partner of the ... President and CEO of two Foundry start-ups. Mr. Engelson ...
(Date:8/29/2014)... WEST JORDAN, Utah , Aug. 29, 2014 /PRNewswire/ ... Imaging Solutions, has acquired Polaris Medical Imaging, a leader ... CT scanners. This strategic acquisition allows BC Technical to ... their capabilities, specifically within MR and CT modalities. ... lower cost service," said Mark Alvarez , president ...
Breaking Medicine Technology:Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2BC Technical Acquires Polaris Medical Imaging 2
... 6, 2012 Silence Therapeutics plc ... RNA interference (RNAi) therapeutics company, announces the ... Collaboration and Delivery Collaboration with its partner AstraZeneca and ... and AstraZeneca was initiated in 2007 and was extended ...
... MADISON HEIGHTS, Mich., Jan. 5, 2012  Yesterday, workers at VPH ... voted for representation with the United Food and Commercial ... security and a voice on the job. The vote ... which workers clearly demonstrated they stood unmoved and united ...
Cached Medicine Technology:Research and Development Collaboration Update 2Research and Development Collaboration Update 3Research and Development Collaboration Update 4
Use the Oculus Mesotest II before and after IOL or refractive surgery. Selectable Landolt ring positions. Accurate measurements in four contrast levels, with and without glare, independent of the pup...
... state-of-the-art electronic medical record the development of ... a proven, comprehensive electronic medical record designed ... at the point of care and to ... through the Internet. AmkaiCharts chronicles patient history, ...
... Systems Information Technologies invites ... yourself how it's award-winning ... - Practice Management (formerly ... simplify your office processes ...
... lamp is designed to for use with ... lamp offers the popular horizontal style light ... ReSeeVit family of slit lamps that offers ... capture clear, crisp digital images in the ...
Medicine Products: