Navigation Links
Could an old antidepressant treat sickle cell disease?
Date:2/19/2013

ANN ARBOR, Mich. An antidepressant drug used since the 1960s may also hold promise for treating sickle cell disease, according to a surprising new finding made in mice and human red blood cells by a team from the University of Michigan Medical School.

The discovery that tranylcypromine, or TCP, can essentially reverse the effects of sickle cell disease was made by U-M scientists who have spent more than three decades studying the basic biology of the condition, with funding from the National Institutes of Health.

Their findings, published in Nature Medicine, pave the way for a clinical trial now being planned for adult patients who have the life-threatening condition. The discovery may also lead to other treatments for the disease, which leads misshapen red blood cells to cause vascular damage and premature death.

But the researchers caution it is too soon for the drug to be used in routine treatment of sickle cell anemia, an inherited genetic disease that affects tens of thousands of Americans and millions of others worldwide.

The climax of a decade of discovery

In the new paper, the researchers describe a painstaking effort to test TCP's effect on the body's production of a particular form of hemoglobin the key protein that allows red blood cells to carry oxygen.

The drug acts on a molecule inside red blood cells called LSD1, which is involved in blocking the production of the fetal form of hemoglobin. The U-M team zeroed in on the importance of LSD1 as a drug target after many years of research.

Then, they literally did a Google search to find drugs that act on LSD1. That's how they found TCP, which since 1960 has been used to treat severe depression.

In the new paper, they describe how TCP blocked LSD1 and boosted the production of fetal hemoglobin -- offsetting the devastating impact of the abnormal "adult" form of hemoglobin that sickle cell patients make.

<
'/>"/>
Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Could a computer on the police beat prevent violence?
2. Indian plant could play key role in death of cancer cells
3. Could Duration of Prostate Cancer Hormone Therapy Be Halved?
4. Low-arsenic rice discovered in Bangladesh could have major health benefits
5. Could A Grill, Skillet or Deep Fryer Become the New Valentine's Day Gift?
6. Breakthrough HIV Technology Could Revolutionize Patient Care in Zimbabwe
7. Drinking Imbalance Could Put Marriage on the Rocks
8. Electronic nicotine delivery systems could help reduce smoking
9. Taking insulin for type 2 diabetes could expose patients to greater risk of health complications
10. Group Therapy: New approach to psychosis treatment could target multiple nervous system receptors
11. Electronic health records could help identify which patients most need ICU resources
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Could an old antidepressant treat sickle cell disease?
(Date:8/1/2014)... Summer is here, and with it comes the ... and they can be a pain for dogs. Animal Emergency ... their customers get rid of ticks and prevent them completely. ... the summer, which is why they are so active during ... woodland areas and carry a number of diseases, including lyme ...
(Date:8/1/2014)... The American Telemedicine Association (ATA) ... and Peter Welch (D-VT), for their latest actions ... Act of 2014, which improves telemedicine coverage in ... improve healthcare access and affordability using telecommunications technology," ... "These cost-saving provisions are critical to improve telehealth ...
(Date:8/1/2014)... 01, 2014 The "Antimicrobial Coatings ... as Zinc Oxide, Titanium Dioxide, and Zinc Omadine), ... Construction, Food & Beverages, Textiles, and others), & ... Global Trends and Forecasts to 2018" analyzes the ... opportunities, and trends in the diverse geographical regions. ...
(Date:8/1/2014)... 2014 The North America Endpoint Security ... market in North America with analysis and forecast of ... $3.53 billion in 2014 to $4.77 billion by 2019, ... , Browse through the TOC of the North America ... the in-depth analysis provided. It also provides a glimpse ...
(Date:8/1/2014)... NY (PRWEB) August 01, 2014 ... Generators Market Outlook to 2020", provides key ... Generators market. The report provides value, in ... and average prices (in US dollars) within ... Generators, Ultrasonic Generators and Argon Plasma Coagulation ...
Breaking Medicine News(10 mins):Health News:Tis the Season for Tick Prevention 2Health News:ATA Applauds Bill on Medicare Telemedicine Improvements 2Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 2Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 3Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 4Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 2Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 3Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 4Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 2Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 3
... Julian, had a brain tumor the size of a golf ball. A ... diagnosed with the same rare form of cancer, called medulloblastoma. Before that, ... III Rhabdomyosarcoma, a very aggressive soft muscle tumor. , ... CHICAGO ...
... Nov. 6 /Xinhua-PRNewswire-FirstCall/ -- Tianyin,Pharmaceutical, Co., Inc., (Amex: ... traditional Chinese medicine ("TCM") based in Chengdu, China,today ... to discuss its,2009 fiscal first quarter at 8:30 ... will be released that day before the market ...
... N.J., Nov. 6 At RSNA 2008 ... MEDQ ) is introducing a,powerful integration ... speech recognition application, and RadWorkFlow(R), a,robust workflow ... offers an efficient, simplified, and consolidated view ...
... 6 Continuing its efforts to,educate, inform, and ... a,not-for-profit patient-focused organization, is hosting its 25-minute live,call-in ... on,Monday, November 10, 2008 at 6:00 PM on ... frank discussion with Joy Loverde, a,nationally known expert ...
... 6 Arizona-based Cain and Associates (C&A),( ... alliance with JDA eHealth Systems, Inc. of ... eHealth Systems will now be able to ... and GRIP (Government,Revenue Integrity Program) products to ...
... and CARLSBAD, Calif., Nov. 6, Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ),announces the following webcast:, ... late-stage research candidates, including presentations ... -- Dr. Erik Stroes reporting top line data from an ongoing ... liver imaging study -- Dr. ...
Cached Medicine News:Health News: Three Women in Health Crises Go Online to Form Lifelong Friendships : Mothers of Boys with Cancer Find Support, Encouragement and Each Other at CarePages.com 2Health News: Three Women in Health Crises Go Online to Form Lifelong Friendships : Mothers of Boys with Cancer Find Support, Encouragement and Each Other at CarePages.com 3Health News:Tianyin Pharmaceutical Co., Inc. to Host Fiscal Year 2009 First Quarter Earnings Conference Call on Tuesday, November 11, 2008 at 8:30 a.m. EST 2Health News:MedQuist Introduces SpeechQ for Radiology Integrated with RadWorkFlow 2Health News:MedQuist Introduces SpeechQ for Radiology Integrated with RadWorkFlow 3Health News:Health Caring for the Elderly 2Health News:Cain & Associates Forms Strategic Partnership With JDA eHealth Systems, Inc. 2Health News:Webcast Alert: Isis Pharmaceuticals' Cardiovascular Program Review 2
(Date:8/1/2014)... and NEW YORK , Aug. 1, ... Pershing Square Capital Management, L.P. today responded to the ... AGN ) in California.  The complaint makes ... tender offer rules.  Allergan,s true purpose ... with shareholders, efforts to call a special meeting.  That ...
(Date:8/1/2014)... 1, 2014  VanDeMark Chemical Inc., ... of phosgene and phosgene derivatives in ... has acquired Framochem Kft, a leading European-based manufacturer ... . The purchase unites two ... of the world,s largest, independent manufacturers of products ...
(Date:8/1/2014)... Aspire Technology Partners (Aspire) announced today that it has achieved ... recognizes Aspire for delivering outstanding customer service to customers in ... "Achieving exceptional results for our customers is core to ... CEO of Aspire. "We are pleased Cisco has recognized our ... are proud to be part of the Cisco channel." ...
Breaking Medicine Technology:Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 2Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 3Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 4Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 5Valeant Pharmaceuticals And Pershing Square Respond To Frivolous Allergan Lawsuit 6VanDeMark Chemical Inc. Acquires Framochem 2VanDeMark Chemical Inc. Acquires Framochem 3VanDeMark Chemical Inc. Acquires Framochem 4Aspire Technology Partners Recognized By Cisco For Excellence In Customer Satisfaction 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: