Navigation Links
Could additives in hot dogs affect incidence of colon cancer?
Date:10/24/2011

BOSTON The addition of ascorbate (vitamin C) or its close relative, erythorbate, and the reduced amount of nitrite added in hot dogs, mandated in 1978, have been accompanied by a steep drop in the death rate from colon cancer, according to data presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

However, the incidence rate for colon cancer has apparently not changed much since 1978, according to 2011 data from the SEER Cancer Statistics Review from the National Cancer Institute.

"It was proposed that N-nitroso compounds in hot dogs and other processed meats can cause colon cancer," said Sidney S. Mirvish, Ph.D., professor emeritus at the Eppley Institute for Research in Cancer and Allied Diseases at the University of Nebraska Medical Center in Omaha. "We found that the level of total apparent N-nitroso compounds in hot dog links prepared in our laboratory fell as increasing levels of sodium erythorbate were included in the hot dog links."

Mirvish and colleagues discussed the view that colon cancer was induced by components of the apparent nonvolatile N-nitroso compounds that occur in processed (nitrite-preserved) meat. Hence, Mirvish and colleagues investigated the effect of varying the erythorbate level on the N-nitroso compound content of hot dogs.

They found that the current level of erythorbate (500 milligrams per kilogram) added to hot dogs reduces the N-nitroso compounds to 2 nanomoles per gram compared with 180 nanomoles per gram when erythorbate was not used.

"When erythorbate was not added, 80 percent of the apparent N-nitroso compounds were found to be due to nitrosothiols, which are probably harmless, still leaving 40 nanomoles per gram that were attributed to possibly carcinogenic N-nitroso compounds," Mirvish said.

If the level of N-nitroso compounds was an important cause of colon cancer, "the drop in N-nitroso compound content caused by the mandated changes in processed meat should have been accompanied by a drop in the incidence of colon cancer," Mirvish said.

In fact, since the mandated changes were introduced 33 years ago, the death rate for colon cancer has dropped sharply. "This may have been due mostly to earlier detection and better treatment of this disease," Mirvish said.

Mirvish concluded that the role of hot dog-derived N-nitroso compounds in the causation of colon cancer remains unclear.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Could HPV Raise Womens Risk for Heart Disease?
2. Physical fitness could have a positive effect on eye health
3. Could Airway Abnormality Point to Autism?
4. Lasers precision and simplicity could revolutionize cataract surgery
5. 3 factors could point to your fate after surgery
6. UCSF study finds steroids could help heal some corneal ulcers
7. Expanding HIV treatment for discordant couples could significantly reduce global HIV epidemic
8. MRIs could become powerful tools for monitoring cholesteral therapy
9. Could Discrimination Help Trigger Illness in Blacks?
10. Permanently dismal economy could prompt men to seek more sex partners
11. Stem cells from cord blood could help repair damaged heart muscle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... ... ... Juan Capistrano summer camp team at the Boys and Girls Club of South Coast ... physical activities for all campers. To read the report, click here or see ... specialty camps that focus on what the report terms as “sitting subjects” like coding or ...
(Date:4/21/2017)... ... April 21, 2017 , ... Chicago plastic surgeon, Dr. Anil ... An osteoma is a benign bony lump located on the forehead usually attributed to ... difficulties with sight and pain. Dr. Shah has discovered an approach that is minimally ...
(Date:4/21/2017)... ... ... The adage “Show, don’t tell” applies perfectly to Green Builder Media’s Earth ... House demonstration project series. Manifesting the concept of right-sized living, the Flex House is ... affordably and abundantly without unduly taxing the resources of our beautiful planet. ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... campaign, AWARE: A Week of Addiction and Recovery Education, from April 24 to ... and preventing substance use disorders. , The mission of AWARE is to ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... candidates to serve on its Accreditation and Standards Committees to support the ... is improving image quality and reducing patient radiation dose,” reports Eliot Siegel, ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE ... Bloom Burton & Co. Healthcare Investor Conference 2017 at the Sheraton ... Edward Wright , Chief Executive Officer of the Company is scheduled ... CFO, Richard Bear and the Chairman of the Board, ... ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 The ... anticipated to showcase a healthy CAGR during the forecast period ... product type in the global digital mobile X-Ray devices market, ... 2,000 Mn in 2017, expanding at a CAGR of 7% ... create absolute $ opportunity of more than US$ 100 Mn ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 ... Surgical drainage devices are tubes used to remove excess ... include, blood, serum, pus, urine, bile or lymph. Surgical ... types of surgery such as orthopedics surgery, cardiovascular surgery, ... device is prophylactic post-surgery to prevent accumulation of fluid ...
Breaking Medicine Technology: