Navigation Links
Could a tumor suppressor also fight obesity?
Date:8/25/2011

PHILADELPHIAThe hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest pandemics: obesity.

Reporting in the August 25 online issue of the Journal of Clinical Investigation, Scott Waldman, M.D., Ph.D., chairman of the Department of Pharmacology and Experimental Therapeutics at Jefferson, and colleagues found that silencing GCC affected appetite in mice, disrupting satiation and inducing obesity. Conversely, mice who expressed the hormone receptor knew when to call it quits at mealtime.

Revealing a never-before-shown endocrine axis between the intestine and hypothalamus, the research could provide novel therapeutic targets to control appetite, obesity and the metabolic syndrome, a promising notion, given that one-third of the U.S. population is considered obese.

Until now, the role of GCC outside the gut has remained elusive. Dr. Waldman and his team have previously shown its role as a tumor suppressor and biomarker that reveals occult metastases in lymph nodes. But its role in appetite is new and surprising territory.

"We were working with GCC-deficient mice to look at its role in tumorigenesis in the intestine," said Dr. Waldman. "Then the mice grew up, and we noticed something: They got fatter.

"We couldn't understand why it was happening, because GCC is expressed predominantly in intestine, and there was no indication that it regulated any function that had to do with metabolism and nutrient uptake."

To investigate this, Dr. Waldman, who also leads the Gastrointestinal Malignancies Program at the Kimmel Cancer Center at Jefferson, and his colleagues ra
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
3. Tiny fruit fly could offer big clues in fight against obesity, researcher says
4. New Book Reveals How Qigong Could Be The Eastern Answer To Botox
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Charging less for more effective treatments could reduce health care costs while improving health
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
9. Most maternal deaths in sub-Saharan Africa could be avoided
10. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
11. New Technology Could Widen Reach of Vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Explorys, the leader in big data-driven healthcare ... Greg Yarrington as Vice President of Operations, Adam Wallace ... Vice President of Solutions. These new leaders are part ... 2015 to support client demand for the company’s big ... growth of its partner network. , Since the ...
(Date:12/22/2014)... Pasadena, CA (PRWEB) December 22, 2014 ... is now offering consultations for sleep apnea. Drowsy drivers ... crashes than drivers who are well-rested, and some experts ... on the roads as intoxicated drivers. Unfortunately, millions of ... to the American Academy of Sleep Medicine, about 18 ...
(Date:12/22/2014)... Christmas is days away, and last minute ... easy solution that will please: the Sublime Gift Card ... from $25 up to $350," says Kathy Heshelow, founder of ... a wide array of skin care products and Skin Brushes." ... dates. , Gift delivery past shipping deadlines, or those ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 At ... Conference, next month in San Antonio, esteemed ... address dynamics that often stand in the way ... competition. , This premier faculty development opportunity ... Transformational Leadership, whose mission is to assist nurse ...
(Date:12/21/2014)... December 22, 2014 BellasDress.com offers a ... for women. Today, it announces its BellasDress Christmas ... at its online store. , BellasDress is a famous ... to its fans through a series of promotions. The ... every customer. , “We are proud of offering ...
Breaking Medicine News(10 mins):Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:BellasDress.com Announces its BellasDress Christmas Sale 2
... 17 Shopko Stores Operating Co., LLC announced the launch ... www.shopko.com . Shopko partnered with SpeedFC, a global ... the Company,s online selling initiatives. , The new online "store" ... apparel, home, accessories, gift cards and more. The site features ...
... of Tulane Cancer Center is the first oncologist in ... treatment for late-stage prostate cancer through a multi-center clinical ... across 20 countries worldwide. The Cancer Center is ... to the bones to take part in a phase ...
... engineered beans might help reduce heart attacks, researchers say ... genetically modified soybeans boosts levels of an important omega-3 fatty ... heart attacks, U.S. researchers say. , They created soybeans that ... by the body into an omega-3 fatty acid called eicosapentaenoic ...
... 17 The Northeast Assisted Fertility Group (NAFG), already the ... is pleased to announce the opening of a new office that ... the Washington, DC area. , Ever since it was founded, ... And now, with its newly expanded pool of donors, carriers, and ...
... , Delivering Benefits Faster to Veterans , ... benefits to many injured servicemembers who receive disability compensation ... announced the expansion of a program with the Department ... people retiring or exiting the military due to disabilities. ...
... controversial drug thalidomide reveals that the mechanism through which ... which causes it to damage internal organs and other ... the challenges surrounding thalidomide research and claims that confirmation ... for Leprosy, Crohn,s Disease, AIDS and some forms of ...
Cached Medicine News:Health News:Shopko Announces Launch of e-Commerce Platform 2Health News:Tulane Cancer Center to begin novel clinical trial for late-stage prostate cancer drug 2Health News:Biotech Soybeans Good Source of Omega-3 2Health News:NAFG Expands Surrogacy and Egg Donation Program into Washington, DC 2Health News:VA and DoD Announce Disability Evaluation System Pilot Expansion 2Health News:Solving the 50-year-old puzzle of thalidomide 2
(Date:12/19/2014)... You,re visiting the dentist for what you ... or she says you need a root canal. Though ... have several questions and feel apprehensive about your upcoming ... nothing to worry about. The Pennsylvania Dental Association (PDA) ... anxiety the public may have surrounding this common procedure ...
(Date:12/19/2014)... , Dec. 19, 2014 In ... research and marketing communication tools are essential for ... competitive – consequently consumers, desires, preferences, and unmet ... environment, market research groups across all industries are ... communication tools. However, the adoption of new market ...
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/942kh3/micro_market ) ... Market Monitor: North American Dermatology Diagnostic Devices Market" ... http://photos.prnewswire.com/prnh/20130307/600769 Cosmetic surgeries ... resulted in fueling the overall demand of the ... these dermatology devices is to assist in identifying ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3
... , , NEW YORK, ... ), a medical technology company testing its proprietary treatment method for ... and Safety Monitoring Board ("DSMB") reviewed clinical data on 77 patients ... that the trial continue to enroll patients with the goal of ...
... , LISBON, Portugal, September 11 ... Confirms Superiority of the New Intranasal Treatment,for Breakthrough Cancer Pain ... today further demonstrate the efficacy of Instanyl in,management of breakthrough ... of the European Federation of Chapters of the International,Association for ...
Cached Medicine Technology:Data Safety Monitoring Board Unanimously Recommends Continuation of Delcath's Phase III Clinical Trial 2Data Safety Monitoring Board Unanimously Recommends Continuation of Delcath's Phase III Clinical Trial 3Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 2Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 3Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 4
... potent, naturally secreted estrogen and is the ... In the ovary, estradiol is produced from ... potent estrogen derived from androstenedione. Estrone and ... In men, small amounts of estradiol are ...
... ADV is a Microparticle ... the quantitative determination of ... human serum or plasma ... Troponin-I values are used ...
... most potent, naturally secreted estrogen and is ... [1]. In the ovary, estradiol is produced ... less potent estrogen derived from androstenedione. Estrone ... tissues. In men, small amounts of estradiol ...
The second-generation Dade Behring Acute Care Troponin I (cTnI) method is the first FDA cleared high sensitivity cTnI assay with the low-end precision necessary to meet the ESC/ACC guidelines (CV <10...
Medicine Products: