Navigation Links
Could a birth control pill for men be on the horizon?
Date:6/4/2011

(NEW YORK, NY, June 4, 2011) Researchers at Columbia University Medical Center are honing in on the development of what may be the first non-steroidal, oral contraceptive for men. Tests of low doses of a compound that interferes with retinoic acid receptors (RARs), whose ligands are metabolites of dietary vitamin A, showed that it caused sterility in male mice.

Earlier results of the experiments using this RAR antagonist were published in the June 1st issue of Endocrinology, and an abstract extending the studies to longer drug delivery periods is scheduled for the Late Breaking Oral Session of ENDO 2011: The 93rd Annual Meeting & Expo in Boston, Massachusetts.

(The abstract, titled Meeting Men's Contraceptive NeedsLong-Term Oral-Administered Retinoic Acid Receptor Antagonist Inhibits Spermatogenesis in Mice with a Reversible and Rapid Recovery, will be presented at the session by first author Sanny S. W. Chung, Ph.D., on Saturday, June 4, 11:15 a.m., Room 157ABC, Boston Convention & Exhibition Center).

The researchers found that low doses of the drug stopped sperm production with no apparent side effects. And crucial for a contraceptive, normal fertility was restored soon after drug administration was terminated.

Earlier research had led the investigators to the discovery that manipulating the retinoid receptor pathway could interfere with the process of spermatogenesis, which is necessary for sperm production.

Scientists have known for almost 100 years that depriving an animal of dietary vitamin A causes male sterility. While investigating targeted loss of function of the gene encoding one of the RARs, RARalpha, which results in male infertility, senior author Debra J. Wolgemuth, Ph.D., ran across a paper by Bristol-Myers Squibb on a compound that was being tested for the treatment of skin and inflammatory diseases. The compound seemed to cause changes in the testis similar to the mutation that she an
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Diabetic drug could help prevent the spread of cancer
2. Could Extreme Low-Cal Diets Bring Longer, Healthier Life?
3. Healthy gut flora could prevent obesity
4. Brisk walking could improve prostate cancer outcomes
5. Consortium identifies genome regions that could influence severity of cystic fibrosis
6. New Stanford device could reduce surgical scarring
7. Common test could help predict early death in diabetes, study shows
8. Study identifies novel role for a protein that could lead to new treatments for rheumatoid arthritis
9. New tool to measure outcomes could help improve arm surgery for devastating nerve injury
10. Viagra could reduce multiple sclerosis symptoms
11. Implant jab could solve the misery of back pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... August 30, 2014 Market Research ... 2009-2019 is a professional and in-depth market survey ... report firstly reviews the basic information of Lab ... The report then explores global and China’s top ... capacity, production value, and market share etc. , ...
(Date:8/30/2014)... Serving contented clients since inception, #1 web design ... is now offering discount for Labor Day on all ... putting forward the best of web development technology before ... of professionals and web developers and designers has expertise ... critical issues of web development and can develop websites ...
(Date:8/30/2014)... York (PRWEB) August 30, 2014 ... transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed against ... to sever four cases selected for one of ... issued on August 18, 2014, U.S. District Judge ... West Virginia disagrees with Boston Scientific’s contention that ...
(Date:8/30/2014)... 2014: Transvenous lead extraction (TLE) is clinically successful in ... the European Lead Extraction ConTRolled (ELECTRa) registry presented for ... Dr Maria Grazia Bongiorni, chair of the registry,s executive ... implantable electronic devices (CIED) implant procedures has grown in ... complications has increased and leads are often the cause. ...
(Date:8/30/2014)... In today’s world, a good night’s sleep ... Snoring and sleep apnea (a medical problem where the ... and their bed partners of the rest they need ... the population snores and 20 million people in the ... 10% have been diagnosed and treated; and of those ...
Breaking Medicine News(10 mins):Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Transvenous lead extraction clinically successful in 98 percent of cases 2Health News:Transvenous lead extraction clinically successful in 98 percent of cases 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3
... German . Tafamidis meglumine (trade name: Vyndaqel) ... in adults. This rare disorder ("orphan disease") is caused by a ... that tafamidis is supposed to delay. According to 35a SGB ... if a drug for a rare disease - known as an ...
... Boston, MA New Harvard School of Public Health (HSPH) ... tool in detecting early breast cancersmay in fact lead to ... have proved harmless. Based on a study of women in ... breast cancer cases are overdiagnosed. The study appears in ...
... HealthDay Reporter , WEDNESDAY, April 4 (HealthDay News) ... called flavonoids, such as berries, apples, tea and red wine, ... 40 percent, new research suggests. For women, however, a ... least several servings of berries a week, according to ...
... Dotinga HealthDay Reporter , WEDNESDAY, April 4 (HealthDay ... HIV vaccine failed to protect most people who received it, ... vaccine efforts. Scientists believe an HIV vaccine, designed to ... several years away. Tests of experimental vaccines have largely been ...
... of scientists, engineers and physicians from Brigham and ... Medical School (HMS), Massachusetts Institute of Technology (MIT), ... State University Karmanos Cancer Institute, and Weill Cornell ... first-in-class targeted cancer drug called BIND-014 in treating ...
... , WEDNESDAY, April 4 (HealthDay News) -- Nine physician specialty ... they believe are often overused or unnecessary, to help doctors ... came up with a list with five tests or procedures ... part of the ABIM Foundation,s Choosing Wisely campaign. ...
Cached Medicine News:Health News:Tafamidis: Approval denotes proven added benefit 2Health News:Routine mammograms may result in significant overdiagnosis of invasive breast cancer 2Health News:Berries, Tea May Cut Men's Odds for Parkinson's: Study 2Health News:Berries, Tea May Cut Men's Odds for Parkinson's: Study 3Health News:From a Failed Vaccine, New Insights Into Fighting HIV 2Health News:First targeted nanomedicine to enter human clinical studies 2Health News:First targeted nanomedicine to enter human clinical studies 3Health News:First targeted nanomedicine to enter human clinical studies 4Health News:Physician Groups Call for Fewer Medical Tests 2
(Date:8/29/2014)... /PRNewswire-iReach/ -- ChemImage will present a workshop focused on ... Forensic Science Society,s 22 nd International Symposium ... Australia .  Forensic Scientists will be in ... imaging can bring to examination procedures. ... Product Development at ChemImage, will host a workshop ...
(Date:8/29/2014)... and MENLO PARK, Calif. , ... Inc. (OTCQB: DMPI) ("DelMar" "the Company") today announced ... statements.  The Company recently changed its fiscal year end ... to list its common stock on a national securities ... financial statements as filed with the United States Securities ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com announces that ... its catalogue: North America Aesthetic Lasers ... http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html North ... to 2020 Summary GlobalData,s new report, ... Outlook to 2020", provides key market data on ...
Breaking Medicine Technology:ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16
... , , TROY, Mich., Jan. 8 ... for the fourth quarter and fiscal year ended November 30, 2009 ... In conjunction with releasing its financial results, the Company will ... a.m. (ET) the same day. , On the ...
... , , PRINCETON, N.J., ... management will present at the 28th Annual JPMorgan Healthcare Conference being ... Francis in San Francisco, CA. Schaefer Price, Pharmasset,s President and Chief ... conference on Thursday, January 14, 2010 at 2:00 PM (PT). , ...
Cached Medicine Technology:Somanetics Corporation to Release Fourth Quarter and Fiscal 2009 Financial Results and Host Conference Call January 21, 2010 2Pharmasset to Present at the 28th Annual JPMorgan Healthcare Conference 2Pharmasset to Present at the 28th Annual JPMorgan Healthcare Conference 3
... eNclose Anastomosis Assist Device ... obviate the need for ... aorta. The enclose device ... with a stable, bloodless ...
15mm Open Blades, 30mm Maximum Blade Spread; in Titanium....
7mm Cross Hairs; Available in 4.5mm to 7.0mm in 0.5mm increments; Ring depth available from 2 to 4mm in 0.5mm increments.; in stainless steel....
2.0mm Rounded Tip, 12mm From Tip to Bend Gently Curved, 15mm Shaft; In Titanium...
Medicine Products: