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Could Statins Help Those Hospitalized With Flu?
Date:12/14/2011

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Dec. 14 (HealthDay News) -- Statins, the drugs that can dramatically lower cholesterol levels, may one day also prove useful in combating serious cases of the flu.

A preliminary study in the Journal of Infectious Diseases finds that patients hospitalized with influenza were less likely to die if they were taking a statin, compared with their peers who weren't taking one of the drugs. The effect held even after adjusting for heart disease.

But it's far too soon to consider adding statins to the existing anti-flu armamentarium, the authors stated.

"At this point, statins should not become the standard of care for people hospitalized with the flu," cautioned study co-author Dr. Ann Thomas, a public health physician with the Oregon Public Health Division in Portland. "We would like to see more studies, [and] I think it would be worthwhile to do these studies."

Right now, preventive vaccinations and antiviral medications are the best weapons against this wily foe, but both stop far short of perfection.

Statins have piqued the interest of virologists and others because they may have anti-inflammatory properties that might mitigate the damage from the influenza virus.

"There have been a couple of studies that have found an apparent association between statins and improved mortality in patients who've had sepsis [blood infections], who've had community-acquired pneumonia," said Dr. Bruce Hirsch, an attending physician in infectious diseases at North Shore University Hospital in Manhasset, NY.

This is the first observational study to investigate a possible relationship between statins and deaths from the flu.

The authors reviewed chart records on more than 3,000 patients hospitalized with laboratory-confirmed influenza in 10 states during the 2007-2008 flu season.

Patients on statins were 41 percent less likely to die, the study
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