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Could Hydrogen Sulfide Hold the Key to A Long Life?
Date:12/3/2007

tissues.

Roth hypothesizes that H2S, a chemical normally produced in humans and animals, may help regulate body temperature and metabolic activity. Hydrogen sulfide is similar to oxygen at the molecular level because it binds at many of the same proteins. As a result, H2S competes for and interferes with the body's ability to use oxygen for energy production -- a process within the cell's power-generating machinery called oxidative phosphorylation.

The inhibition of this function, in turn, is what Roth and colleagues believe causes organisms such as mice to shut down metabolically and enter a hibernation-like state pending re-exposure to normal room air, after which they quickly regain normal function and metabolic activity with no long-term negative effects.

The National Institutes of Health, the NIH Center for Research Resources, the Caenorhabditis Genetics Center and a National Research Service Award Fellowship supported this work.

At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit http://www.fhcrc.org.

CONTACT

Kristen Woodward

(206) 667-5095

kwoodwar@fhcrc.org


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SOURCE Fred Hutchinson Cancer Research Center
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