Navigation Links
Could Dogs' DNA Give Clues to Human Lymphoma?
Date:4/12/2011

TUESDAY, April 12 (HealthDay News) -- Scientists are rearranging the genetic information of certain dogs to make the coding human-like as a way to learn more about the genetic causes in people of non-Hodgkin's lymphoma, a cancer that begins in the cells of the immune system.

Humans and dogs have a similar genetic makeup and share the same types of cancers, including lymphoma. In purebred dogs of the same breed, however, there are fewer genetic variations than in humans, making it simpler to locate areas of the canine chromosomes that may be involved with cancer.

In a new study, North Carolina State University researchers gathered genetic information from dogs with non-Hodgkin's lymphoma and then rearranged, or recoded, the genomes of the dogs into human configuration.

The recoded dog genomes were then compared with the genomes of people with non-Hodgkin's lymphoma to identify chromosomes involved in the cancer in both humans and dogs.

"This is the first time that we were able to compare this information from dogs with lymphoma directly with existing data from human patients diagnosed with the equivalent cancer and using the same technique," lead author Rachael Thomas, a research assistant professor of molecular biomedical sciences at N.C. State, said in a university news release.

She and her colleagues found that dogs and humans share only a few genes that are involved with lymphoma. Previous research had suggested that numerous genes in humans may be associated with lymphoma.

The researchers said that the new findings should help narrow the search for the genes most likely to cause lymphoma in people.

"In essence, we stripped the background noise from the human data," Matthew Breen, a professor of genomics, said in the news release. "Lymphoma genomics is a lot more complex in human patients than in dog patients. This study tells us that, while both humans and dogs have comparable disease at the clinical and cellular level, the genetic changes associated with the same cancers are much less complex in the dog. This suggests that maybe there is a lot of genetic noise in the human cancers that is not an essential component of the process.

"While human studies have been looking in numerous places in the genome, the dog data indicate we need to focus on what's shared, and these are very few regions," Breen said.

The study was published online in Leukemia and Lymphoma.

More information

The U.S. National Cancer Institute has more about non-Hodgkin's lymphoma.

-- Robert Preidt

SOURCE: North Carolina State University, news release, April 6, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
3. Tiny fruit fly could offer big clues in fight against obesity, researcher says
4. New Book Reveals How Qigong Could Be The Eastern Answer To Botox
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Charging less for more effective treatments could reduce health care costs while improving health
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
9. Most maternal deaths in sub-Saharan Africa could be avoided
10. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
11. New Technology Could Widen Reach of Vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Could Dogs' DNA Give Clues to Human Lymphoma?
(Date:2/6/2016)... ... February 06, 2016 , ... ... 5000 PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , WHAT: ... world with an estimated 5000 perioperative nurses in attendance to study the ...
(Date:2/5/2016)... ... ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran the Miami Marathon on January ... year, he ran all 26.2 miles with a green 25-pound ShelterBox strapped to his ... This Sunday, while many are watching the Superbowl, Steven Tonkinson will strap on the ...
(Date:2/5/2016)... , ... February 05, 2016 , ... The event is ... Day Block Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 ... owner of Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this ...
(Date:2/5/2016)... Toronto, Ontario (PRWEB) , ... February 05, 2016 , ... ... the Scarborough General Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned ... the Scarborough Hospital. He successfully completed his first three-year term as chief and began ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each January, ... to access the treadmills. It’s a predictable trend. After the excesses of November and ... in shape by joining gyms, starting new walking or running routines, or signing up ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... -- The Senior Care Pharmacy Coalition (SCPC) today commended ... Jason Chaffetz (R-UT) and Ranking Member Elijah ... "Developments in the Prescription Drug Market," to examine ... abusive pharmacy benefit manager (PBM) pricing practices. ... Elijah Cummings (D-MD) are diligent, serious lawmakers committed ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... filed in the United States District Court for the District ... class (the "Class") consisting of all persons or entities who ... "Company") (NASDAQ: INSY ) from March 3, 2015 through ... and certain of its officers with violations of the Securities ...
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
Breaking Medicine Technology: