Navigation Links
Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
Date:11/18/2010

ion and smoking.

Mrs de Graan and her colleagues at Erasmus studied the use of dextromethorphan, the active ingredient in cough suppressant medicine, in 40 breast cancer patients who had been taking tamoxifen for more than three weeks. Dextromethorphan is metabolised in the same way as tamoxifen and is harmless to the patient. "It is a so-called 'probe' drug, a harmless substance that can be used to predict the metabolism of another drug. We used dextromethorphan to evaluate its use as a probe drug for tamoxifen metabolism," she said.

The researchers gave their patients 30mg of dextromethorphan as liquid cough syrup and then asked them to take their oral tamoxifen two hours later. Over the next 24 hours they took different blood samples to measure both dextromethorphan and tamoxifen metabolites, and then calculated how well dextromethorphan metabolism predicted and correlated with tamoxifen metabolism.

"We found that dextromethorphan is a very good way to predict endoxifen concentrations," said Mrs de Graan. One patient was taking the anti-depressant, paroxetine, which is known to inhibit CYP2D6, and the dextromethorphan probe accurately predicted the resulting lower concentrations of endoxifen.

Measuring dextromethorphan is easier than measuring levels of the metabolite endoxifen and, in addition, it can be applied to other compounds that are metabolised by CYP2D6 and CYP3A.

"Tamoxifen is prescribed to women for as much as five years in the adjuvant setting, so it is highly important to know beforehand if the therapy is going to be effective. When it is known that a woman metabolises tamoxifen poorly, a switch in drugs or an increase in dose can be considered. Looking at a patient's genetic make-up (genotyping) is one possible way to predict the metabolism of an individual patient, but it only looks at one gene for one enzyme involved in the metabolism of tamoxifen: CYP2D6. However, tamoxifen is also metabolised by anoth
'/>"/>

Contact: Emma Mason
wordmason@mac.om
ECCO-the European CanCer Organisation
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related medicine news :

1. Too Few Adults Vaccinated Against Whooping Cough: CDC
2. Spread of Whooping Cough Raises Concern
3. Commentary suggests alternatives to routine use of OTC cold/cough meds in children
4. New commentary suggests alternatives to routine use of OTC cold/cough meds in children
5. TechWorld Medicals NasalCare Nasal Cleanse Kit Named “Best New Product” at ECRM Cough & Cold and Allergy Conference
6. Lung cancer patients are the centerpiece for Northwestern medicine quality of care study
7. Personalized medicine: Tumor analysis reveals new opportunities for existing cancer drugs
8. The color of medicine
9. Texas Center for Cancer Nanomedicine targets 2 tough cancers
10. Organic solvent system may improve catalyst recycling and create new nanomedicine uses
11. Neuroimaging leader to receive the 2010 Taylor Prize in Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... 2013 When looking for ways to ... figure out how to lose belly fat and excess fat ... and thighs. Unnecessary and excess fat storage in these areas ... Diet Doc created their hCG diets to specially ... powerful weight loss aids with nutritious meal plans and education ...
(Date:6/19/2013)... 19, 2013 Blueforce Development Corporation, ... machine software, today announced it has been awarded ... Fusion Engine technology. The award coincides with ... of key strategic partnerships. , Blueforce Development ... and machine-to-machine (M2M) software products that support the ...
(Date:6/19/2013)... June 19, 2013 Walkingspree, a specialized ... announced the launch of its new Facebook App. This ... and inspire participants to reach their program fitness goals. ... , Walkingspree clients are given more tools to customize ... profile. , Corporate clients may choose whether or not ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 The reason for ... is because users can place a 4x8 flood tray inside ... space to work around. In addition, Gorilla Grow Tents ... they are the tallest, thickest and strongest grow tents on ... for grow tent standards. , Gorilla Grow Tents ...
(Date:6/19/2013)... The website HealthNewsWires.com has recently published an ... effects and tips to manage and prevent the condition. ... the author defines insulin resistance as a ... process glucose from the bloodstream. Glucose, or blood ... organs and systems of the body for normal function. ...
Breaking Medicine News(10 mins):Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announce A New Four Phase Program that Allows Patients to Lose Belly Fat, Thigh Fat and Underarm Fat Easily 2Health News:Blueforce Awarded Patent for Decentralized Sensor Fusion 2Health News:Walkingspree’s New Facebook Connectivity Boosts Accountability and Engagement 2Health News:Stealth Grow Tent Brand’s Popularity Rises 2Health News:Effects of Insulin Resistance and How to Increase Insulin Sensitivity Published in New Video by Health News Wire 2
... Center New Orleans School of Nursing has been ... Johnson Foundation (RWJF) to provide scholarships to individuals ... an accelerated nursing degree program. The funding will ... Education, or CARE, Program, expanding enrollment and the ...
... CHAPEL HILL Nearly every child who receives an ... or atypical drugs, such as olanzapine and risperidone. However, ... more effective than the older, first-generation medications., ,Now a ... Hill School of Medicine suggests that molindone, a first-generation ...
... identified variations in a single gene that are strongly ... was conducted by researchers at the National Institutes of ... Hopkins University. The findings are published online today in ... be published in the October print issue. , ...
... the UK-based secure publishing specialist, today announced the launch of its ... and extremely flexible incremental pricing plan, Drumlin is set to provide ... ... UK (PRWEB) September 14, 2008 -- Drumlin Security ( ...
... WYNDMOOR, Pa., Sept. 12 Since Vice President hopeful,Governor ... Trig,her baby diagnosed with Down syndrome, a new light ... for the children, their parents, and the,professionals who have ... with Down syndrome often have slower development in,mobility, language, ...
... NAF High School to Demonstrate How Z,Trim Can Improve the Nutritional Profiles ... ... #165, MUNDELEIN, Ill., Sept. 12 Z Trim Holdings,Inc. (Amex: ... and Tourism Academy of Baltimore,s National Academy,Foundation (NAF) High School to demonstrate ...
Cached Medicine News:Health News:LSUHSC awarded grant to address nursing shortage 2Health News:First generation antipsychotic drugs as effective as newer ones in some children 2Health News:First generation antipsychotic drugs as effective as newer ones in some children 3Health News:Newly found gene variants account for kidney diseases among African-Americans 2Health News:Newly found gene variants account for kidney diseases among African-Americans 3Health News:Newly found gene variants account for kidney diseases among African-Americans 4Health News:Drumlin Security Launches Ground-breaking Low Cost PDF Publishing Service 2Health News:How to Help Down Syndrome and Other Special Needs Children - Free Booklet and Parenting Course Available This Month From The Institutes for the Achievement of Human Potential 2Health News:Z Trim Multifunctional Fiber Lightens the Menu Labeling Legislation Issue at Mid-Atlantic Food Expo, September 17 & 18 2Health News:Z Trim Multifunctional Fiber Lightens the Menu Labeling Legislation Issue at Mid-Atlantic Food Expo, September 17 & 18 3Health News:Z Trim Multifunctional Fiber Lightens the Menu Labeling Legislation Issue at Mid-Atlantic Food Expo, September 17 & 18 4Health News:Z Trim Multifunctional Fiber Lightens the Menu Labeling Legislation Issue at Mid-Atlantic Food Expo, September 17 & 18 5
(Date:6/18/2013)... PROSPECT, Ill. , June 18, 2013 /PRNewswire-iReach/ ... of its new X3130 Appliance Inlet Module. The ... circuit breaker , combines a C14 appliance inlet ... one compact package.  This three-in-one device allows design ... their designs - cutting installation time by 66 ...
(Date:6/18/2013)... Mass. , June 18, 2013 ... the company was named Overall Performance Leader in Imaging ... Equipment & Infrastructure report. Philips also received Best in ... its imaging products: Ingenuity Core 128 Computed Tomography ... ultrasound and PageWriter TC70 cardiograph. The annual Best in ...
(Date:6/18/2013)... 18, 2013 Unilife Corporation ("Unilife" or "Company") ... and manufacturer of injectable drug delivery systems, today announced ... www.unilife.com . The new site includes additional products, videos, ... on a regular basis. Mr. Alan ... emerging global leader for injectable drug delivery systems, we ...
Breaking Medicine Technology:Three-in-One X3130 Appliance Inlet Module 2Philips Named 2013 Overall Performance Leader In Imaging Equipment By KLAS 2Unilife Launches New Corporate Website 2
... Inc. (Nasdaq: MSHL ), an oncology company ... cancer metabolism, announced today that it has filed a ... Exchange Commission for a rights offering to existing stockholders ... stock. The Company will announce further details regarding the ...
... Feb. 21, 2012  Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ... will present a company overview at Citi,s 2012 Global Health ... ET at the Waldorf Astoria in New York City. ... available on the "Investors & Media" section of the Company,s ...
Cached Medicine Technology:Marshall Edwards Announces Rights Offering to Stockholders 2Marshall Edwards Announces Rights Offering to Stockholders 3
... USA 2001 Universal Battery Charger is manufactured to ... Versipower Plus and 3M MaxiDriver II Battery Packs. ... six Battery Packs simultaneously in less than 40 ... on 120 volt AC grounded electrical power. If ...
... The Brasseler USA™ Battery Packs contain ... age have a great impact upon battery ... is necessary. Any deviation from these recommendations ... are sensitive to heat. Any exposure of ...
The High Speed Drill handpiece is a well-balanced, high performance drill that provides high speed for,bone sculpting, along with power for difficult osteotomies. Must be used with the 6401-000 foot ...
... Module, with hand throttle. Accepts all 1000 ... 10ft. air hose 9000-000, or existing hose ... hose 9013-000, or existing hose with Linvatec/Hall ... or existing hose with 3M connector (1000-300). ...
Medicine Products: