Navigation Links
Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
Date:11/18/2010

Cough medicine could be used as way of predicting how well individual patients metabolise tamoxifen used in the treatment of their breast cancer, according to new research presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Friday).

The findings suggest that it could be possible to use cough suppressant syrup as a probe, which would enable doctors to identify patients with altered metabolism and use this information to improve individual treatment, making it more effective and reducing the chances of side-effects.

Tamoxifen, which is widely used both to treat and prevent breast cancer, is metabolised by the body into endoxifen, which is responsible for the drug's anti-cancer activity and which can cause tamoxifen-related side-effects. Two enzymes, CYP2D6 and CYP3A, are responsible for metabolising tamoxifen into endoxifen, and the metabolite forms only if there are sufficient quantities of these enzymes.

Mrs Anne-Joy de Graan, a PhD student in the medical oncology department at the Erasmus Medical Centre in Rotterdam (The Netherlands), who presented the study, explained: "At present, all patients treated with tamoxifen in The Netherlands are prescribed a fixed dose of 20 mg or 40 mg. But there is a large difference in the toxicity (for example, hot flushes, endometrial cancer and thrombosis) and efficacy of this agent. This is thought to be the result of variance in endoxifen concentrations between patients. Recently, research has focused on whether this variation in endoxifen levels is caused by patients' individual genetic make-up. We know that there are genetic variations that cause women to be 'poor metabolisers'. This means that these women cannot form enough endoxifen due to absence of CYP2D6 enzymatic activity." In addition, other factors can influence a way a woman metabolises tamoxifen, such as CYP3A enzymatic activity, the use of other medicines, alcohol consumpt
'/>"/>

Contact: Emma Mason
wordmason@mac.om
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Too Few Adults Vaccinated Against Whooping Cough: CDC
2. Spread of Whooping Cough Raises Concern
3. Commentary suggests alternatives to routine use of OTC cold/cough meds in children
4. New commentary suggests alternatives to routine use of OTC cold/cough meds in children
5. TechWorld Medicals NasalCare Nasal Cleanse Kit Named “Best New Product” at ECRM Cough & Cold and Allergy Conference
6. Lung cancer patients are the centerpiece for Northwestern medicine quality of care study
7. Personalized medicine: Tumor analysis reveals new opportunities for existing cancer drugs
8. The color of medicine
9. Texas Center for Cancer Nanomedicine targets 2 tough cancers
10. Organic solvent system may improve catalyst recycling and create new nanomedicine uses
11. Neuroimaging leader to receive the 2010 Taylor Prize in Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... 28, 2015 My Shiney Hiney® LLC., the ... team to Las Vegas, Nevada for the annual ASD Market ... of the leading consumer-goods tradeshows and My Shiney Hiney will ... event. My Shiney Hiney can be found at booth number ... for the at-home personal hygiene brush and cleansing system exclusively ...
(Date:2/27/2015)... Sacramento, Calif. (PRWEB) February 27, 2015 ... of liver-disease death, between four and 12 years earlier ... study from UC Davis Health System. , While previous ... ALD than other populations, the new study -- published ... -- is believed to be the first to pinpoint ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 OnChip ... (IPD), has introduced miniature, wire bondable, silicon ESD (Electrostatic ... LED markets. The ESD88NP and ... away from sensitive LED and IC products. These ... Varistors (MLV). All devices meet the requirements of ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Just a ... air for those suffering from Sjögren’s Syndrome after a ... by researchers at the University of Buffalo and Immco ... of research was to develop a new diagnostic ... the presence of new autoantibodies. Researchers aimed to develop ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Today, February 27th, ... KAJ Brothers , along with LXR Organics and ... END IT Campaign to raise awareness and promote prevention, rescue ... statistics provided by the END IT Coalition, slavery is the ... year and exists in 167 countries around the world. Slavery ...
Breaking Medicine News(10 mins):Health News:My Shiney Hiney® to Participate in ASD Market Week 2015 2Health News:UC Davis Study Finds Hispanics Develop Alcoholic Liver Disease at Younger Ages than Caucasians or African Americans 2Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 2Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 3Health News:Breakthrough Blood Test for Early Detection of Sjögren’s Syndrome Now Available 2Health News:KAJ Brothers Join the Campaign to 'End It - Shine A Light On Slavery' 2
... drink, smoke and use drugs are influenced more by ... increase the risk of substance abuse in teenage girls, ... that risk factors for substance abuse are different in ... professor of human genetics, says in a news release.//, ...
... in soluble fibre and low in saturated fats can lower ... new study found, suggesting medication-free cholesterol control may be viable ... that a diet heavy in okra, eggplant, soy proteins, oatmeal ... LDL cholesterol levels after just one month. ,Participants ...
... week may cut their risk of Alzheimer's by more than ... that diet may affect a person's chances of developing the ... that people 65 and older who had fish once a ... those who never or rarely ate fish. The meals included ...
... has been cloned by scientists at The Scripps Research ... that detect viruses or bacteria on the surfaces of ... and bacteria into immune system responses that fight the ... of Nature, found that Trif is the topmost protein ...
... Common painkillers may lower the risk of developing Alzheimer's ... the benefit, scientists said on Friday. They reviewed 15 ... non-steroidal anti-inflammatory drugs (NSAIDs), and found people who take ... is the leading cause of dementia in the elderly. ...
... Clinic in Rochester, Minn., say they have found a ... is an allergic inflammatory reaction of the esophagus. The ... research shows a topical corticosteroid therapy is effective for ... of high levels of eosinophils. Eosinophils are a type ...
Cached Medicine News:
(Date:2/26/2015)... Feb. 26, 2015  Mail-service and specialty pharmacies ... employers and government health plans $23.3 billion over ... the Pharmaceutical Care Management Association (PCMA). ... one of the easiest ways to reduce health ... Merritt . "Policymakers should resist efforts to restrict ...
(Date:2/26/2015)... Feb. 26, 2015 Every year many millions ... fight heart disease.  Nevertheless, year after year doctors and ... as the first test to determine the status of ... pain or not, even though that technology is over ... fact that doctors know, (while most patients do not ...
(Date:2/26/2015)... DUBLIN , Feb. 26, 2015 Research and ... addition of the "Radiation Therapy Equipment - Global ... This report analyzes the worldwide markets for ... Product Segments: Linear Accelerator, Treatment Planning Systems, and Radiation ... the US, Canada , ...
Breaking Medicine Technology:PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Texas Employers, Consumers and Public Programs by $23.3 Billion 2National Heart Health Month In February 2Radiation Therapy Equipment - Global Strategic Business Report 2015-2020: Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator 2
... 2011 Reportlinker.com announces that a new market research report ... Products http://www.reportlinker.com/p060973/Cosmetic-Surgery-Products.html ... Demand for products used in cosmetic surgery is forecast ... 2014, when 16.1 million cosmetic procedures are expected to be ...
... 2011 Medco Health Solutions, Inc. (NYSE: MHS ... to present at the following healthcare conferences: (Logo: ... CEOs Unscripted conference taking place in New York at the ... 8:45 a.m. ET; The 29th Annual JPMorgan ...
Cached Medicine Technology:Reportlinker Adds Cosmetic Surgery Products 2Reportlinker Adds Cosmetic Surgery Products 3Medco CEO to Present at Upcoming Healthcare Conferences 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: