Navigation Links
Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
Date:11/18/2010

Cough medicine could be used as way of predicting how well individual patients metabolise tamoxifen used in the treatment of their breast cancer, according to new research presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Friday).

The findings suggest that it could be possible to use cough suppressant syrup as a probe, which would enable doctors to identify patients with altered metabolism and use this information to improve individual treatment, making it more effective and reducing the chances of side-effects.

Tamoxifen, which is widely used both to treat and prevent breast cancer, is metabolised by the body into endoxifen, which is responsible for the drug's anti-cancer activity and which can cause tamoxifen-related side-effects. Two enzymes, CYP2D6 and CYP3A, are responsible for metabolising tamoxifen into endoxifen, and the metabolite forms only if there are sufficient quantities of these enzymes.

Mrs Anne-Joy de Graan, a PhD student in the medical oncology department at the Erasmus Medical Centre in Rotterdam (The Netherlands), who presented the study, explained: "At present, all patients treated with tamoxifen in The Netherlands are prescribed a fixed dose of 20 mg or 40 mg. But there is a large difference in the toxicity (for example, hot flushes, endometrial cancer and thrombosis) and efficacy of this agent. This is thought to be the result of variance in endoxifen concentrations between patients. Recently, research has focused on whether this variation in endoxifen levels is caused by patients' individual genetic make-up. We know that there are genetic variations that cause women to be 'poor metabolisers'. This means that these women cannot form enough endoxifen due to absence of CYP2D6 enzymatic activity." In addition, other factors can influence a way a woman metabolises tamoxifen, such as CYP3A enzymatic activity, the use of other medicines, alcohol consumpt
'/>"/>

Contact: Emma Mason
wordmason@mac.om
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Too Few Adults Vaccinated Against Whooping Cough: CDC
2. Spread of Whooping Cough Raises Concern
3. Commentary suggests alternatives to routine use of OTC cold/cough meds in children
4. New commentary suggests alternatives to routine use of OTC cold/cough meds in children
5. TechWorld Medicals NasalCare Nasal Cleanse Kit Named “Best New Product” at ECRM Cough & Cold and Allergy Conference
6. Lung cancer patients are the centerpiece for Northwestern medicine quality of care study
7. Personalized medicine: Tumor analysis reveals new opportunities for existing cancer drugs
8. The color of medicine
9. Texas Center for Cancer Nanomedicine targets 2 tough cancers
10. Organic solvent system may improve catalyst recycling and create new nanomedicine uses
11. Neuroimaging leader to receive the 2010 Taylor Prize in Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Dallas, Texas (PRWEB) August 23, 2014 ... deterioration of the function of the myocardium (the ... heart failure; common symptoms are dyspnea (breathlessness) and ... cardiomyopathy are often at risk of dangerous forms ... The most common form of cardiomyopathy is dilated ...
(Date:8/23/2014)... Peripheral intervention surgeries are part of the ... addressing the root cause of peripheral artery disease. Peripheral ... other part of the arteries where the blood clot ... the use of a catheter, (which is a thin ... are inserted through a thin cut in an artery, ...
(Date:8/23/2014)... York, New York (PRWEB) August 23, 2014 ... http://www.consumerinjurylawyers.com/wright-conserve-hip-replacement.html ) filed on behalf of individuals ... the Conserve hip replacement line continue to move ... of Georgia, Bernstein Liebhard LLP reports. According to ... established a bellwether trial program that would allow ...
(Date:8/23/2014)... 2014 Professional kitchen employees, prospective chefs ... in preparing for Food Safety Certification exams thanks to ... Dynamic Path. , Dynamic Path announced the release of ... than 200 review questions for culinary industry students and ... cover requirements of the ServSafe® Food Safety Certification, National ...
(Date:8/23/2014)... August 23, 2014 Teen drug and ... It’s no different in Wilmington, NC. Substance abuse can ... falling victim to drug and alcohol dependency in higher ... looking to overcome substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
Breaking Medicine News(10 mins):Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 2Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 3Health News:Cardiomyopathy (Heart Muscle Disease) Therapeutics Clinical Trials Market 2014 Analysis in a New Report Available at MarketOptimizer.org 4Health News:Global Peripheral Intervention Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Health News:Global Peripheral Intervention Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Health News:Global Peripheral Intervention Market: Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:Food Handler Safety Certification Made Easy with Dynamic Path 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2
... thermal performance of protective clothing worn by firefighters. A ... the burns received by firefighters when they are not ... burns. Researchers at North Carolina State University have developed ... suits to be evaluated for their ability to prevent ...
... and nutritional benefits; Packaging now more environmentally responsibleNEW YORK, ... to the enhanced water category, PepsiCo (PEP) is re-launching ... water beverage designed to help hydrate and nourish the ... Propel is available in a variety of ...
... In recognition of April as National Autism Awareness Month, LoJack Corporation ... at: http://www.lojack.com/knowledge/Documents/AutismAwarenessMonth.mp3 ) that provided valuable ... The rising incidence of autism in ... challenges of caring for an autistic child , ...
... no problems at 6 months of use , , TUESDAY, ... Cialis (tadalafil) and Viagra (sildenafil) didn,t appear to damage ... six months, according to a drug company study. , ... treat erectile dysfunction by interfering with the action of ...
... marketing exclusivityPITTSBURGH, April 14 Mylan Inc. (Nasdaq: ... its subsidiary Mylan Pharmaceuticals Inc. have been sued by ... an Abbreviated New Drug Application (ANDA) with the U.S. ... mg and 500 mg, the generic version of Xeloda(R) ...
... WILMINGTON, Del., April 14 Patent litigation firm Teuton, ... Therative, Inc. on behalf of inventor Joseph Neev, PhD. ... District Court, District of Delaware, Dr. Neev claims sole ... issued patent that Therative claims protects its ThermaClear Acne ...
Cached Medicine News:Health News:NC State develops new test method to measure stored heat in firefighter suits 2Health News:Propel Unveils New Enhanced Experience 2Health News:Propel Unveils New Enhanced Experience 3Health News:April is National Autism Awareness Month: LoJack Hosts Educational Podcast Featuring Panel of Experts Addressing Autism Issues 2Health News:Impotence Drugs Don't Harm Vision: Study 2Health News:Mylan Confirms First-to-File Patent Challenge Relating to Xeloda(R) Cancer Treatment 2Health News:Inventor Sues Therative, Inc. Over Inventorship of Patent on ThermaClear Device; Separate Invention Theft Case Continues 2
(Date:8/22/2014)... 22, 2014 Research ... addition of the  "Global Operating Room Equipment ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating ... environment in a healthcare facility used to ... technically advanced equipment, which ensures patient care ...
(Date:8/22/2014)... /CNW/ - On Aug. 20, at its annual meeting ... Association (CMA) voted on and approved a delegate resolution ... cannabis. Bedrocan Cannabis Corp., a leading Canadian licensed producer ... The CMA is quite right to point ... any plant material, including medicinal cannabis. While some patients, ...
(Date:8/22/2014)... , Aug. 22, 2014 Research and ... "Global and Chinese Intravenous Catheter Industry Report 2014" ... and Chinese Intravenous Catheter Industry Report 2014 is a ... the global intravenous catheter industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
Breaking Medicine Technology:Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Global and Chinese Intravenous Catheter Industry Report 2014 2
... 2, 2012 CVS Caremark Corporation (NYSE: CVS ) ... months ended March 31, 2012. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO ... , Net revenues increased 19.9% to a record $30.8 ... , Retail Pharmacy segment same stores sales increased ...
... Ill., May 2, 2012  Celebrity chef Spike Mendelsohn knows all ... – especially for a person with acid reflux disease (ARD). ... Spike has also had to learn how to turn down ... awareness and understanding about the importance of managing heartburn symptoms ...
Cached Medicine Technology:CVS Caremark Reports Record First Quarter Results 2CVS Caremark Reports Record First Quarter Results 3CVS Caremark Reports Record First Quarter Results 4CVS Caremark Reports Record First Quarter Results 5CVS Caremark Reports Record First Quarter Results 6CVS Caremark Reports Record First Quarter Results 7CVS Caremark Reports Record First Quarter Results 8CVS Caremark Reports Record First Quarter Results 9CVS Caremark Reports Record First Quarter Results 10CVS Caremark Reports Record First Quarter Results 11CVS Caremark Reports Record First Quarter Results 12CVS Caremark Reports Record First Quarter Results 13CVS Caremark Reports Record First Quarter Results 14CVS Caremark Reports Record First Quarter Results 15CVS Caremark Reports Record First Quarter Results 16Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 2Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 3Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 4Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 5
Used for drainage and retrograde pyelogram. The spiral tip aids in negotiation of a tortuous or partially obstructed ureter. Supplied sterile in peel-open packages. Intended for one-time use....
Used for drainage and retrograde pyelogram. Supplied sterile in peel-open packages. Intended for one-time use....
Used for drainage and navigation of a tortuous ureter. The tapered tip eases placement as there are no edges to interfere with the ureteral orifice. Supplied sterile in peel-open packages. Intended f...
These flexible stone retrieval devices are reusable, 3 Fr in diameter, with a working length of either 60 cm or 115 cm...
Medicine Products: