Navigation Links
Cough Syrup Might Help With Dosing of Breast Cancer Drug
Date:11/19/2010

FRIDAY, Nov. 19 (HealthDay News) -- A new, small study suggests that the main ingredient in cough syrup might help doctors determine the best dose of tamoxifen, a drug commonly used to prevent and treat breast cancer.

The idea is that the body absorbs cough medicine at about the same rate as tamoxifen, allowing doctors to use it to test how patients respond to the breast-cancer drug.

"This study is starting to identify a personalized medicine type of approach that will help identify those patients who should have their tamoxifen doses adjusted," said Dr. Leonidas Koniaris, who's familiar with the study findings. He's an associate professor of surgery at the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine in Florida.

Currently, it can be difficult to set a proper dose of tamoxifen for a patient. If the dose is off, the drug may lose effectiveness or cause a higher number of side effects, the study authors said.

The authors, led by Anne-Joy de Graan, a graduate student at Erasmus Medical Center in Rotterdam, the Netherlands, focused on whether dextromethorphan, the active ingredient in cough medicine, is metabolized by the body at about the same rate as tamoxifen. Dextromethorphan "is a so-called 'probe' drug, a harmless substance that can be used to predict the metabolism of another drug," de Graan said in a news release provided by the European Cancer Organization.

The study authors gave 30 milligrams of dextromethorphan in cough syrup form to 40 breast cancer patients and then gave them tamoxifen two hours later. Over the next 24 hours the researchers determined whether the women's bodies metabolized the drugs at similar rates. They did.

The cough medicine test needs more research and isn't ready to be used in doctors' offices, Koniaris stressed. The next steps will be to validate the research and see if the test results actually lead to better health for patients. For now, he said, "it certainly looks quite promising."

The study findings were to be released Friday at the Symposium on Molecular Targets and Cancer Therapeutics in Berlin, Germany. Research presented at meetings should be viewed as preliminary until it is published in a peer-reviewed journal.

More information

There's more on tamoxifen at the U.S. National Cancer Institute.

-- Randy Dotinga

SOURCES: European Cancer Organization, news release, Nov. 19, 2010; Leonidas Koniaris, M.D., an associate professor of surgery, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
2. Too Few Adults Vaccinated Against Whooping Cough: CDC
3. Spread of Whooping Cough Raises Concern
4. Commentary suggests alternatives to routine use of OTC cold/cough meds in children
5. New commentary suggests alternatives to routine use of OTC cold/cough meds in children
6. TechWorld Medicals NasalCare Nasal Cleanse Kit Named “Best New Product” at ECRM Cough & Cold and Allergy Conference
7. New Simply...Go-Gurt Contains No High Fructose Corn Syrup, Artificial Flavors or Colors
8. Nerve Zap to Kidneys Might Ease Stubborn Hypertension
9. Cholesterol on Eyelids Might Point to Heart Risk
10. Special Infant Formula Might Help Shield Babies from Type 1 Diabetes
11. Diabetes Drugs Might Lower Risk of Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cough Syrup Might Help With Dosing of Breast Cancer Drug
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Coco Libre, ... participation in Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer ... to stay hydrated before the big event. The invitation-only gifting suite, held this year ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Every winter, ... , This winter the West Penn Burn Center, part of the Allegheny ... #1, to bring you the “Space Heaters Need Space” campaign. , ...
(Date:2/12/2016)... ... 2016 , ... Vail knee specialist Robert LaPrade, MD, PhD was ... The list consists of physicians establishing, leading and partnering with ambulatory surgery centers across ... Ambulatory Surgery Center, also known as an ASC, is a modern health care facility ...
(Date:2/12/2016)... FLA (PRWEB) , ... February 12, 2016 , ... Miami ... dental implants to their Miami dental office. Beginning in January, Miami Dental Specialists ... titanium. Miami Dental Specialists are the first office to be chosen by the dental ...
(Date:2/12/2016)... Pass, OR (PRWEB) , ... February 12, 2016 ... ... contains an article about foods choices that promote eye health. These articles generally ... vision health. Water and health advocate Sharon Kleyne endorses every one of these ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016   HeartWare International, Inc . (NASDAQ: ... webcast to discuss its financial results for the three ... February 25, 2016 at 8:00 a.m. ET.  The company ... conference call and webcast.  On the conference call and ... from the fourth quarter and business outlook.   ...
(Date:2/12/2016)... ALISO VIEJO, Calif. , Feb. 12, 2016 /PRNewswire/ ... patient enrollment in a study to evaluate the safety ... specifically for the treatment of ruptured intracranial aneurysms.  Prof ... Bicetre University Hospital, in Paris, France ... the first patient. France ...
(Date:2/12/2016)... 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ARLZ ) ... will ring the Nasdaq Closing Bell at the Nasdaq ... at 4:00 p.m. ET on Tuesday, February 16, ... Adrian Adams , will perform the honorary bell ... p.m. ET.  A live webcast will be available at: ...
Breaking Medicine Technology: