Navigation Links
Cottonseed-based drug shows promise in treating severe brain cancer
Date:5/28/2009

BIRMNGHAM, Ala. An experimental drug derived from cottonseed shows promise in treating the recurrence of glioblastoma multiforme, widely considered the most lethal brain cancer, said researchers at the University of Alabama at Birmingham (UAB).

The new results are from a Phase II clinical trial of AT-101, a pill manufactured from a potent compound in cottonseed that overcomes the abnormal growth patterns of tumor cells. This cottonseed-based agent must be properly dosed and monitored by physicians.

In clinical tests, AT-101 halted the cancer's progression in many of the 56 patients, said John Fiveash, M.D., an associate professor in the UAB Department of Radiation Oncology and the lead researcher on the new study.

Despite undergoing other treatments, including surgery, chemotherapy and radiation, the trial patients' brain cancer had begun to grow again prior to starting AT-101 treatments. The trial-monitored patients took only AT-101 daily for three out of four weeks. Glioblastomas are more common in adults and are considered fast-growing brain tumors that are very difficult to treat, Fiveash said.

"After getting this drug some of these patients went many months without any new growth in their tumors," Fiveash said. "We are able to do that with a well-tolerated oral medication, and that is a major benefit." His initial results will be presented May 30 during the poster discussion of central nervous system tumors at the American Society for Clinical Oncology annual meeting in Orlando, Fla.

Fiveash said the drug would likely work best in combination with radiation and chemotherapy to boost the cancer-fighting properties of those treatments. Also, investigators are trying to learn which patients are most likely to benefit from AT-101.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Page: 1

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. New research shows how chronic stress worsens neurodegenerative disease course
3. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
4. Circulating fats kill transplanted pancreas cells, study shows
5. New Heart Pump Shows Promise in Trial
6. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
7. New Survey Shows Americans are Still Concerned About Food Safety, Yet Still Not Smart About What They Like to Eat
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
10. Avocados may help prevent oral cancer, OSU study shows
11. New Poll Shows Public Distrusts Flawed Healthcare Approach Favored by Governor and Speaker in AB 8
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... University,s Center for Leadership in Disability (CLD) has ... and Child Health Bureau of the Health Resources ... Autism Plan for Georgia, aimed at improving services ... , In preparing for this project, CLD worked ... stakeholders from across Georgia. The resulting plan addresses ...
(Date:8/27/2014)... Los Angeles, CA (PRWEB) August 27, 2014 ... everyone. To do this, Jaha invested in creating the industry’s ... motivation by adding functions that no other apps possess. ... with a tracker that differentiates in three simple steps: locate, ... will launch on Tuesday, Aug 26, 2014 to garner support ...
(Date:8/27/2014)... Ontario (PRWEB) August 27, 2014 Cash ... direct impact on the overall upkeep of the shelter including ... most importantly helping to change the lives of each youth ... a 35 bed emergency shelter for youth ages 16-25. Not ... offers many programs and resources for the youth who come ...
(Date:8/27/2014)... August 27, 2014 The Global and ... study on the current state of the Maleic Anhydride ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 Many ... The reality is that depression has a mortality rate ... with bi-polar disorder is slightly less, though it's offset ... roughly 7%. In order to properly treat and ... and bi-polar, medication must be taken as directed. ...
Breaking Medicine News(10 mins):Health News:Jaha, Inc. The Most Affordable Fitness Band in the Market Released on Kickstarter 2Health News:Cash House a Major Supporter of Horizons for Youth 2Health News:Cash House a Major Supporter of Horizons for Youth 3Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 2Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 3Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 4Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 5Health News:MedicationDiscountCard.com now Makes Brintellix and Mental Illness Medications More Affordable with Discount Cards 2
... rich in meat, cheese and whole milk may be ... and the stomach.The rates of two types of cancer--gastric ... the past 30 years. To investigate potential links between ... cancers and dietary factors, Dr. Susan T. Mayne from ...
... a vacuum device promoted as a breast-enhancer does increase a ... commitment to use the product. The device, known as the ... their breasts for 10 hours a day for 10 weeks ... vacuum device. Skipping even a day adds a week to ...
... amounts of water is very essential for an individual. One ... a day, says a leading physiologist. We've been led to ... a day that's eight glasses// of volume eight ounces ... Heinz Valtin of Dartmouth Medical School, there is no real ...
... techiques. Laser hair removal is a useful remedy for ingrowing ... 'razor bumps' after they shave.// The medical name is pseudofolliculitis ... of a shaved hair grows back into the skin, forming ... painful and it may even leave scars. ,Growing ...
... a new study shows that people with a low potassium ... a stroke. Previous research has suggested that reduced quantities of ... stroke. //The focus on potassium is, perhaps, a new one ... or salt intake low to avoid stroke. But sodium and ...
... is released into the blood after a meal, restrain the ... treating obesity. The reason for feeling full after a meal, ... acts on the brain to produce a feeling of satiety. ... human trial of PYY3-36. ,10 healthy volunteers received ...
Cached Medicine News:Health News:Vacuum device increase breasts 2
(Date:8/27/2014)... 2014 Ambit Biosciences (Nasdaq: AMBI ), a ... unmet needs in oncology, autoimmune and inflammatory disease, today announced ... to be held at The New York Palace Hotel in ... 2014. Alan Fuhrman , Ambit,s CFO, will ... candidate, quizartinib, at 1:10 p.m. ET on Wednesday, September 3, ...
(Date:8/27/2014)... Pa. , Aug. 27, 2014   Auxilium Pharmaceuticals ... integrated specialty biopharmaceutical company, today announced that certain members ... Morgan Stanley Healthcare Conference to be held September 8-10, ... Adrian Adams , Chief Executive Officer and President, is ... its product portfolio at 10:55 a.m. ET on Wednesday, ...
(Date:8/26/2014)... , Aug. 27, 2014 Higher ... insurance are fuelling the demand for medical devices ... rise of medical tourism, the inflow of patients ... The market will continue its steady ascent as ... age-related and non-communicable diseases, compelling significant investments in ...
Breaking Medicine Technology:Ambit Announces Participation At Baird 2014 Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Morgan Stanley Healthcare Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Morgan Stanley Healthcare Conference 3Frost & Sullivan: Change in Demographics and Surge in Domestic Manufacturing Drive Asia-Pacific Medical Devices Market 2Frost & Sullivan: Change in Demographics and Surge in Domestic Manufacturing Drive Asia-Pacific Medical Devices Market 3Frost & Sullivan: Change in Demographics and Surge in Domestic Manufacturing Drive Asia-Pacific Medical Devices Market 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: