Navigation Links
Cost of treating colorectal cancer can vary by thousands per patient

DURHAM, N.C. -- The cost of treating colorectal cancer varies widely, with newer, life-extending therapies sometimes costing tens of thousands of dollars more than older agents, according to a study led by a team of researchers in the Duke Comprehensive Cancer Center.

"The total cost of chemotherapy to treat colorectal cancer may differ by as much as $36,999 per patient, depending on the regimen," said Gary Lyman, M.D., an oncologist and health outcomes researcher at Duke, and senior investigator on this study. "We know that some therapies are more promising and effective, in general, than others, and cost variation raises many questions about what kind of care patients are receiving and whether this economic burden is matched by significant clinical advancements, especially with regard to quality of life."

The findings appeared in the November 2008 issue of the American Journal of Managed Care. The study was funded by the Duke Comprehensive Cancer Center's Health Services and Outcomes Program.

The researchers identified the eight most commonly prescribed treatment regimens within a cohort of more than 400 patients who were treated at 115 ambulatory care centers across the United States. Regimens included supportive agents often needed to combat treatment-related side effects such as nausea, and varied from an older chemotherapy cocktail known as 5-FU/ LV (5-fluoroucil and leucovorin calcium), to newer therapies that include the use of bevacizumab, commonly known as Avastin. Bevacizumab was FDA-approved in 2004 for the treatment of colorectal cancer, and works by choking off a tumor's blood supply.

"The cost of treating colorectal cancer has skyrocketed," Lyman said. "We have seen similar trends in terms of rapidly rising costs of drug development in breast cancer and other malignancies, but nowhere has this been more striking than in the management of colorectal cancer."

The introduction of life-extending therapies for colorectal cancer over the past several years, which can in some cases almost double survival time, has led to a 340-fold increase in the cost of chemotherapy, Lyman said. The burden of this increase is felt by insurers, by patients and their families and ultimately, by taxpayers, he said.

"For many of these colorectal cancer patients, depending on how advanced their disease is, we may be talking about buying a few months," he said. "And these rapidly increasing costs have raised ethical questions about whether such sums of money should be dedicated to treatments that may modestly prolong life but not offer increased cure rate."

Lyman said that these findings may suggest that new strategies should be sought to limit the economic impact of these newer treatment regimens, including appealing to drug companies to reassess their pricing policies and relaxing prohibitions on the federal government negotiating drug prices.

There is also concern, Lyman said, that some patients, especially in smaller, rural areas, may have limited access to care or be receiving older, "out-of-date" therapies because of either the patient's or the practice's inability to pay for the newer agents.

"At the same time, it may be prudent for researchers and clinicians to search for improved prognostic and predictive markers that may permit more selective or targeted application of expensive therapies in patients who stand to derive the most clinical benefit from them," he said. "Such strategies may provide not only the most effective but also the most cost-effective use of these new agents for patients with colorectal cancer."


Contact: Lauren Shaftel Williams
Duke University Medical Center

Related medicine news :

1. K-State Veterinarian Discusses Treating Dogs With Cushings Disease
2. Treating Osteoporosis After Hip Fracture
3. Integrative Medicine Pioneer To Host Free Groundbreaking Web Series on a Natural Approach for Treating Depression
4. New topical approach to treating nail fungus circumvents problems with current therapy
5. Doctors Test Advanced Tool for Treating Prostate Cancer
6. Researcher to provide new insight for treating vascular disease
7. CytoDyn, Inc. Prepares for New Clinical of Its First-In-Class Drug for Treating HIV/AIDS
8. Chemo Alone Effective in Treating Kids Brain Tumors
9. Newer antipsychotics no better than older drug in treating child and adolescent schizophrenia
10. Positive Findings Published on Emergent Technology for Treating Chronic Pain
11. Key to treating cancer may be finding its original cell
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping in mind ... mental health and wellness consultation, has collaborated with a leading web-based marketplace for ... gap experienced by parents and bring advice from parenting experts within their reach. ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... most successful and prominent nonprofit healthcare organizations in the country. They have overseen ... various organizations, and helped advance the healthcare industry as a whole through their ...
(Date:11/27/2015)... Francisco, California (PRWEB) , ... November 27, 2015 , ... ... Janis Joplin Ann Arbor Michigan boxing style concert posters. This is one of Joplin's ... at the Canterbury House at the University of Michigan in Ann Arbor. The According ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... Cambridge, ON (PRWEB) , ... November 26, 2015 ... ... availability of a real-time eReferral system for diagnostic imaging in the Waterloo region. ... mammography, BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/25/2015)... ) ... "Global Brain Monitoring Devices Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:11/25/2015)... AAIPharma Services Corp./Cambridge Major Laboratories, Inc. ... $15.8  Million to expand its laboratories and global ... The expansion will provide additional office space and ... of the pharmaceutical and biotechnology markets. ... up to 40,000 square feet of expanded development ...
Breaking Medicine Technology: