Navigation Links
Cost of treating colorectal cancer can vary by thousands per patient
Date:11/7/2008

DURHAM, N.C. -- The cost of treating colorectal cancer varies widely, with newer, life-extending therapies sometimes costing tens of thousands of dollars more than older agents, according to a study led by a team of researchers in the Duke Comprehensive Cancer Center.

"The total cost of chemotherapy to treat colorectal cancer may differ by as much as $36,999 per patient, depending on the regimen," said Gary Lyman, M.D., an oncologist and health outcomes researcher at Duke, and senior investigator on this study. "We know that some therapies are more promising and effective, in general, than others, and cost variation raises many questions about what kind of care patients are receiving and whether this economic burden is matched by significant clinical advancements, especially with regard to quality of life."

The findings appeared in the November 2008 issue of the American Journal of Managed Care. The study was funded by the Duke Comprehensive Cancer Center's Health Services and Outcomes Program.

The researchers identified the eight most commonly prescribed treatment regimens within a cohort of more than 400 patients who were treated at 115 ambulatory care centers across the United States. Regimens included supportive agents often needed to combat treatment-related side effects such as nausea, and varied from an older chemotherapy cocktail known as 5-FU/ LV (5-fluoroucil and leucovorin calcium), to newer therapies that include the use of bevacizumab, commonly known as Avastin. Bevacizumab was FDA-approved in 2004 for the treatment of colorectal cancer, and works by choking off a tumor's blood supply.

"The cost of treating colorectal cancer has skyrocketed," Lyman said. "We have seen similar trends in terms of rapidly rising costs of drug development in breast cancer and other malignancies, but nowhere has this been more striking than in the management of colorectal cancer."

The introduction of life-extending therapies for colorectal cancer over the past several years, which can in some cases almost double survival time, has led to a 340-fold increase in the cost of chemotherapy, Lyman said. The burden of this increase is felt by insurers, by patients and their families and ultimately, by taxpayers, he said.

"For many of these colorectal cancer patients, depending on how advanced their disease is, we may be talking about buying a few months," he said. "And these rapidly increasing costs have raised ethical questions about whether such sums of money should be dedicated to treatments that may modestly prolong life but not offer increased cure rate."

Lyman said that these findings may suggest that new strategies should be sought to limit the economic impact of these newer treatment regimens, including appealing to drug companies to reassess their pricing policies and relaxing prohibitions on the federal government negotiating drug prices.

There is also concern, Lyman said, that some patients, especially in smaller, rural areas, may have limited access to care or be receiving older, "out-of-date" therapies because of either the patient's or the practice's inability to pay for the newer agents.

"At the same time, it may be prudent for researchers and clinicians to search for improved prognostic and predictive markers that may permit more selective or targeted application of expensive therapies in patients who stand to derive the most clinical benefit from them," he said. "Such strategies may provide not only the most effective but also the most cost-effective use of these new agents for patients with colorectal cancer."


'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. K-State Veterinarian Discusses Treating Dogs With Cushings Disease
2. Treating Osteoporosis After Hip Fracture
3. Integrative Medicine Pioneer To Host Free Groundbreaking Web Series on a Natural Approach for Treating Depression
4. New topical approach to treating nail fungus circumvents problems with current therapy
5. Doctors Test Advanced Tool for Treating Prostate Cancer
6. Researcher to provide new insight for treating vascular disease
7. CytoDyn, Inc. Prepares for New Clinical of Its First-In-Class Drug for Treating HIV/AIDS
8. Chemo Alone Effective in Treating Kids Brain Tumors
9. Newer antipsychotics no better than older drug in treating child and adolescent schizophrenia
10. Positive Findings Published on Emergent Technology for Treating Chronic Pain
11. Key to treating cancer may be finding its original cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... Kenall Manufacturing, a leader in sealed healthcare ... The MPCNGX is a multi-function, sealed, LED luminaire that meets the needs of everyone ... when it’s needed. , A 2’ x 4’ model features four modes: ...
(Date:12/7/2016)... ... December 07, 2016 , ... OC87 Recovery Diaries ... schizophrenic mother in a unique, personal perspective through animation. , That woman ... addictive disorders at her private psychotherapy practice. Sheri’s mother, Pearl, lived with schizophrenia. ...
(Date:12/7/2016)... ... 2016 , ... Castle Dermatology Institute is now offering liquid facelifts with ... appearance to the face. Dr. Peyman Ghasri and Dr. Pedram Ghasri, San Fernando ... to rejuvenate and renew the facial appearance. , Sculptra is a highly effective ...
(Date:12/7/2016)... ... 07, 2016 , ... When it came time to blow out his candles on his 14th ... Pediatric Heart Transplant team at Joe DiMaggio Children’s Hospital surprised his family with ... 30th heart transplant recipient. , “He was playing at home, when we got the ...
(Date:12/7/2016)... TX (PRWEB) , ... December 07, 2016 , ... ... offering insurance and financial planning services to families and business owners in the ... funds on behalf of the Dallas Fallen Officer Foundation. , Established in 2009 ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)...  Licenders is bringing their 100% all-natural lice removal service to ... at 203 13 th Street was specifically chosen to make ... "Our goal is to ease parents, stress and bring their ... children right back to class without skipping a beat. The best ... for the whole family," Licenders President Adie Horowitz states. ...
(Date:12/6/2016)... 6, 2016  "Blood Tests replace Surgical Biopsies. ... The Diagnostic, Monitoring and Screening Test opportunities ... is occurring using in vitro blood testing to ... impressive backing, has announced a single blood test ... faster than the market. New technology that definitively ...
(Date:12/6/2016)... 2016 Diabetes & Obesity Drug Development Pipeline ... disease cluster is currently dominated by therapeutics indicated for ... mellitus (T2DM), and the majority of the pipeline, in ... attributable to these indications. While products indicated for obesity ... are a large number of these products in the ...
Breaking Medicine Technology: