Navigation Links
Cost-effectiveness of cetuximab in metastatic colorectal cancer
Date:8/7/2009

From a health-care system perspective, it may be more efficient to use the drug cetuximab only in colorectal cancer patients whose tumors have a wild-type KRAS gene, according to a study published online August 7 in the Journal of the National Cancer Institute.

Earlier, patients whose tumors harbored wild-type KRAS were found to have a higher survival advantage when treated with cetuximab in a randomized trial by the National Cancer Institute of Canada Clinical Trials Group.

In this study, Nicole Mittmann, of the HOPE Research Centre Sunnybrook Health Sciences Centre, in Toronto, and colleagues used prospectively collected resource utilization and health utility data from that trial to conduct a cost-effectiveness analysis to determine the costs per life-year gained and costs per quality-adjusted life-year gained.

Mean survival times for the study arms were calculated over an 18- to 19-month period for all patients in the study and for patients whose tumors had wild-type KRAS.

For all patients, cetuximab showed very high (i.e., unfavorable) incremental cost-effectiveness ratiosmeaning it was very costly in relation to benefitscompared with best supportive care. The incremental cost-effectiveness ratios were, however, more favorable for patients whose tumors harbored wild-type KRAS.

"Consequentlyit would not be efficient to fund cetuximab treatment for all patients with advanced colorectal cancer," the authors write. "Use of cetuximab may be restricted based on a patient's tumor KRAS status."

In an accompanying editorial, Robin Yabroff, Ph.D., of the Division of Cancer Control and Population Science, National Cancer Institute in Bethesda, Md., and Deborah Schrag, M.D., of the Dana Farber Cancer Institute in Boston, note that these findings help raise important questions about how cost-effectiveness analyses inform coverage decisions.

Ideally, personalization of cancer therapy could save money by avoiding treatment for patients with KRAS mutations who do not respond to cetuximab, according to the editorialists. However, this study shows that even when restricted to metastatic colorectal cancer patients with wild-type KRAS tumors, the cost-per quality adjusted life year gained for cetuximab therapy compared to best supportive care exceeds commonly accepted thresholds of $50,000 to $100,000 per quality adjusted life year that signify "good value" health care interventions.

Given current attention to healthcare costs in the U.S., interest in explicitly comparing the costs and benefits of treatment, as performed by Mittmann et al. in Canada, is likely to increase. "The sustainability of the current approach to decision-making about coverage is unclear, particularly in light of escalating health care costs," the editorialists write.


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Study details cost-effectiveness of rheumatoid arthritis treatments for Medicare recipients
2. MedImmune to present RSV surveillance and cost-effectiveness data at American Academy of Pediatrics
3. Fox Chase finds that lung cancer patients respond to erlotinib following cetuximab therapy
4. Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer
5. Researchers Identify New Method to Selectively Kill Metastatic Melanoma Cells
6. Researchers identify new method to selectively kill metastatic melanoma cells
7. Chicago team uses artificial intelligence to diagnose metastatic cancer
8. Smoking increases potential for metastatic pancreatic cancer
9. Positive CHMP Opinion for JAVLOR(R) in Metastatic Treatment of Bladder Cancer After Failure of a Prior Platinum-Containing Regimen
10. Clinical Studies Validate Cancer Gene Delivery Platform: Landmark Publication Confirms Rexin-G Effectively Targets Metastatic Cancers and Improves Patient Survival
11. 2-drug combination appears safe and active in metastatic kidney cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... ... genetic testing for medications in select Florida and Texas doctors' offices and clinics. ... This new application of genetic testing recognizes the role genes play in determining ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island Quality Institute ... Alerts and Dashboards, an innovative new service enabling healthcare providers to proactively coordinate ... Alerts and Dashboards provide near real-time data about patients admitted to and/or discharged ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association of America ... secretary of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman currently serves ... Bowman brings an intimacy with the issues and challenges veterans face with the VA. ...
(Date:6/23/2017)... CA (PRWEB) , ... June 23, 2017 , ... The ... facelift . Dr. Talei has come up with a proprietary technique that he ... and lifts tissues that have dropped. For all ages, patients can expect to look ...
(Date:6/23/2017)... ... , ... PureLife Dental is pleased to announce that California Dental Association (CDA) ... of the amalgam separator endorsement, all CDA members may purchase an ECO II amalgam ... value. This partnership between PureLife and CDA is especially timely as it coincides with ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), will ... webcast on Friday, July 28, 2017, beginning at 7:30 a.m. ... Only Dial-in information: To participate in the conference call, dial ... the call at least 10 minutes prior to the start ... Webcast: A simultaneous ...
(Date:6/16/2017)... , June 16, 2017 Datascope Corp. is voluntarily ... Datascope Corp. for a potential electrical test failure code.     ... PART NUMBER ... IABP CS300 IABP ... ...
(Date:6/14/2017)... 2017  ivWatch LLC, a medical device company focused ... therapy, is pleased to announce it was the Bronze ... Supplies and Equipment at the 2017 Medical Design Excellence ... industry. The award was presented by Medical Device and ... in New York during MD&M ...
Breaking Medicine Technology: