Navigation Links
Cost-effective method accurately orders DNA sequencing along entire chromosomes
Date:11/7/2013

between regions of the chromosomes in a genome, including contact within a chromosome and with other chromosomes. The results indicate which regions tend to occur near each other within three-dimensional space in a cell's nucleus.

The researchers speculated that this interaction data, because it offers clues about the position of and distances between various regions of the chromosome, might reveal how DNA sequences are grouped and lined up along entire chromosomes. They wondered if the interaction data could show them which regions of the genome are near each other on each chromosome.

Their investigation of this possibility led them to create what they named LACHESIS (an acronym for "ligating adjacent chromatin enables scaffolding in situ"). The map of physical interactions generated by Hi-C was interpreted by the LACHESIS computational program to assign, order and orient genomic sequences into their correct position along chromosomes, including DNA positioned close to the centromere, the "pinch waist" gap in the chromosome shape.

The researchers combined their new approach with other cheap and widely used sequencing methods to generate chromosome-scale assemblies of the human, mouse and fruit fly genomes. The researchers were able to cluster nearly all scaffolds -- collections of short DNA segments whose position relative to each other is unknown -- into groups that corresponded to individual chromosomes.

They then ordered and oriented the scaffolds assigned to each chromosome group, and validated their results by comparing them to the high-quality reference genomes for these species that were generated by the Human Genome Project. In the case of human genomes, they achieved 98 percent accuracy in assigning tens of thousands of sequences of contiguous DNA to chromosome groups and 99 percent accuracy in ordering and orienting these sequences within chromosome groups.

"We think the method may fundamentally change how
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UC Davis study applies timely cost-effectiveness analysis to state breast cancer screening program
2. Screening at-risk adolescents for celiac disease proves cost-effective
3. Stanford study examines cost-effectiveness of helicopter transport of trauma victims
4. Research finds targeted screening for hepatitis C is cost-effective
5. A shortcut to timely, cost-effective interventions for HIV
6. Acucote Inc. Reveals Cost-effective, Clean-release Coupon
7. UCLA study finds heart failure medications highly cost-effective
8. Study: Catheter-based varicose vein treatments more cost-effective
9. Preventing HIV infection with anti-HIV drugs in people at risk is cost-effective
10. Pitt study examines cost-effectiveness of medicare drug plans in schizophrenia and bipolar disorder
11. Telestroke networks can be cost-effective for hospitals, good for patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... Call 866-997-4948 (Us-Canada Toll Free) Tel: +1-518-618-1030 ... on sales(at)researchmoz(dot)us , Researchmoz.us announces a new research ... with deep study of the report on the diabetes ... sugar. The global glucose monitoring market has a growth ... of diabetics in the world. Their numbers have prompted ...
(Date:11/26/2014)... November 26, 2014 For those with a ... LES MILLS BODYPUMP™ classes at the University of ... workout they've been looking for. The 45- 60 minute classes ... Health and Wellness Center fitness club memberships. , LES MILLS ... are fast-paced and are aimed at fast results , ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 Sonoran ... ANP-BC, recently received the Distinguished Preceptorship Award from ... for her role in the advancement of nurse ... of an individual who had made a significant ... NPs. The American Association of Nurse Practitioners (AANP) ...
(Date:11/26/2014)... News) -- Vultures have developed highly specialized ways of ... dead animals, researchers report. The new research investigated ... and in the guts of 50 turkey vultures and ... faces of the vultures had more than 500 different ... the study found. The findings suggest that a ...
(Date:11/26/2014)... Nov. 25, 2014 (HealthDay News) -- Exposure to peanut ... peanut allergy in infants with the skin condition eczema, ... school-aged children in the United States are allergic to ... to food allergies, particularly peanut allergy, the researchers noted. ... months to 15 months. The researchers examined the amount ...
Breaking Medicine News(10 mins):Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 3Health News:LES MILLS BODYPUMP™ classes come to the University of Colorado Anschutz Health and Wellness Center 2Health News:Sonoran Nurse Receives Distinguished Preceptorship Award from The American Association of Nurse Practitioners 2Health News:Infants With Eczema May Be More Prone to Peanut Allergy: Study 2
... ... Noni Fruit , ... (Vocus) May 19, 2010 -- Tahitian Noni International (TNI) has announced the creation ... company leaders have realized that noni is more than just a juice-and they are using ...
... ... Experience, View Their Photos, and Learn What Footwear To Pack for an African Safari , ... Seattle, Wash. (PRWEB) May 17, 2010 -- Good ... online shoe retailer before embarking on her honeymoon, vowing to pack only five pairs of shoes ...
... ... and young adults are ready for plastic surgery. , ... Voohees, NJ (Vocus) May 19, 2010 -- In light of recent media coverage of ... surgeon , Dr. Paul M. Parker, saw a great opportunity to address the right way to ...
... The neXante ... and xMM skin, respectively on Basal Cell Cancer, Squamous Cell Cancer, and Malignant Melanoma of ... only tracks and stores images of the skin, but also allows for recording the diagnosis, ... ...
... ... offers unique source of income for hard pressed primary care physicians. , ... Sacramento, CA (PRWEB) May 19, ... soon overwhelm private practice groups across the country with 31 million new patients. ...
... ... Angel Investors. , ... (PRWEB) May 19, 2010 -- SeniorHomes.com , an online directory and resource for ... it received a $1.1 million of Series A financing led by MentorTech Ventures of ...
Cached Medicine News:Health News:New Bioactive Beverages Available From Tahitian Noni International 2Health News:The Bachelor's Molly Malaney Blogs About Honeymoon at Onlineshoes.com 2Health News:The Bachelor's Molly Malaney Blogs About Honeymoon at Onlineshoes.com 3Health News:With the Right Approach, Plastic Surgery for Teens and Young Adults is Now a Positive Experience 2Health News:With the Right Approach, Plastic Surgery for Teens and Young Adults is Now a Positive Experience 3Health News:With the Right Approach, Plastic Surgery for Teens and Young Adults is Now a Positive Experience 4Health News:With the Right Approach, Plastic Surgery for Teens and Young Adults is Now a Positive Experience 5Health News:neXante Turns Apple's iPhone Into Skin Cancer Surveillance Support Tool And Health Record 2Health News:Physicians Preferred Wellness Group Receives Prestigious MD Preferred Service Award 2Health News:SeniorHomes.com Closes $1.1 Million Series A Round of Investment Financing 2
(Date:11/26/2014)... China, Nov. 26, 2014 China Nepstar Chain ... "Company"), a leading retail drugstore chain in China based ... its unaudited financial results for the third quarter ended September ... 30, 2014: , Same store sales increased by ... , Revenue increased by 8.1% to RMB738.3 million (US$120.3 million) ...
(Date:11/24/2014)...  Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) announced today ... and update at the Piper Jaffray 26 th Annual ... Eastern Time (5:30 a.m. Pacific Time), at The New York ... A live audio webcast of the presentation will be ... www.arenapharm.com . A replay of the presentation will be ...
(Date:11/24/2014)... /PRNewswire/ - Milestone Pharmaceuticals, Inc. today announced data from a ... Melbourne, Australia of MSP-2017, a novel ... paroxysmal supraventricular tachycardia (PSVT).  The results demonstrated that ... at single doses up to and including 140 ... properties including rapid onset, and validating proof of ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 11Arena Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2Arena Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 3Milestone Announces Positive Phase 1 Data for MSP-2017; Supports Advancement into Phase 2 in PSVT Patients 2Milestone Announces Positive Phase 1 Data for MSP-2017; Supports Advancement into Phase 2 in PSVT Patients 3
... Oct. 5, 2011 Reportlinker.com announces ... is available in its catalogue: ... Dermatological Drugs, 7th Edition ... This Kalorama Information report details the ...
... Calif., Oct. 5, 2011 In an independent study ... the University of Texas Health Science Center San Antonio ... to compromised blood flow during reconstructive microsurgery when compared ... study by Dr. Cornejo and colleagues is important as ...
Cached Medicine Technology:The Market for Prescription Dermatological Drugs, 7th Edition 2The Market for Prescription Dermatological Drugs, 7th Edition 3The Market for Prescription Dermatological Drugs, 7th Edition 4The Market for Prescription Dermatological Drugs, 7th Edition 5The Market for Prescription Dermatological Drugs, 7th Edition 6The Market for Prescription Dermatological Drugs, 7th Edition 7The Market for Prescription Dermatological Drugs, 7th Edition 8The Market for Prescription Dermatological Drugs, 7th Edition 9The Market for Prescription Dermatological Drugs, 7th Edition 10The Market for Prescription Dermatological Drugs, 7th Edition 11The Market for Prescription Dermatological Drugs, 7th Edition 12The Market for Prescription Dermatological Drugs, 7th Edition 13The Market for Prescription Dermatological Drugs, 7th Edition 14The Market for Prescription Dermatological Drugs, 7th Edition 15Spectros T-Stat Shown to Be Earliest Available Method for Detection of Surgical Skin Flap Compromise After Surgery 2
The Fathom Guidewire combines a nitinol hypotube distal segment with advanced microfabrication technology, creating a design that revolutionizes access of the most tortuous vasculature....
... for stent delivery. Uses perpendicular applied ... Allows user to adjust stent position ... tactile feel via fine adjustment and ... visualization at any angle. The Cordis ...
Vial with 100 Urine Reagent Test Strips, tests for glucose, protein, pH, blood, ketone, bilirubin, nitrite, urobilinogen, specific gravity. FOR LABORATORY USE BY QUALIFIED TECHNICIANS....
... the latest from Quality Mapping Solutions, ... designed specifically for implementing and managing ... superior design, functionality, security, and versatility ... managing a quality program., ,Based upon ...
Medicine Products: