Navigation Links
Correction: Abatacept found ineffective in treatment of non-life threatening lupus
Date:9/29/2010

steroids have serious side effects, so treatments that are targeted and could control disease activity while allowing steroid tapering would represent an advance in lupus therapy," said lead author of the current study, Joan T. Merrill, M.D. of the Oklahoma Medical Research Foundation.

Dr. Merrill and colleagues conducted the first trial to assess the effects of abatacept on disease flares in patients with non-life threatening SLE. There were 175 patients included in the trial whose primary symptoms included active polyarthritis, chronic discoid skin lesions, pleuritis, and/or pericarditis. Participants were randomized with 118 administered abatacept (10mg/kg of body weight) by intravenous (IV) infusion on days 1, 15, 29 and every 4 weeks throughout the 12-month period. There were 57 patients in the placebo group who received normal saline IV infusion. Prednisone (30 mg/day) was administered to both groups for 1 month and then tapered.

At the completion of the study 68.6% of participants remained in the abatacept group and 61.4% in the placebo group. Researchers found the most frequent reason for discontinuation was lack of efficacy17.8% in the abatacept group and 21.1% in the placebo cohort. Further more, the proportion of patients with a new flare following the steroid taper was 79.7% and 82.5% in the abatacept and placebo groups, respectively. In ad hoc analyses, there were greater differences when severe flares or physician-reported flares were analyzed separately, and in the subset of patients who entered the study with active arthritis, but these findings are considered exploratory and would require confirmation in future studies.

The research team also found that the frequency of patients with serious adverse events (SAEs) was higher in participants receiving abatacept (19.8%) than with those in the placebo group (6.8%). SAEs were single events ranging from nausea to lupus nephritis, and most often occurred during the
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. Highmark Foundation Awards $120,000 to the American Heart Association
4. Stuttering Foundation Hails New Research
5. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
6. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
7. Corbett Accel Healthcare Group Mourns Passing of Founder Frank J. Corbett
8. Reliv Foundation Donates $450,000 In Nutritional Supplements to Haitian Relief Efforts
9. Kaiser Foundation Health Plan and Hospitals Report Fourth Quarter and Fiscal Year 2009 Financial Results
10. Instaflex Announces Proceeds Agreement with Arthritis Foundation
11. AMERICAN IDOL to Benefit the UN Foundation Fund for Haiti Thursday, February 25, on FOX
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 31, 2015 , ... Committed to helping the next generation succeed ... members to contribute to the College’s “My Brother’s Keeper Scholarship.” The President’s signature initiative ... on track. Providing the support they need to think more broadly about their future. ...
(Date:7/30/2015)... ... July 30, 2015 , ... As more hospitals across the ... recruiting patients becomes a serious challenge. Because of growing competition, it is more ... the local community. , The team at Wound Care Advantage has ...
(Date:7/30/2015)... ... 2015 , ... OSF Healthcare System has been recognized as one ... conducted by Hospitals & Health Networks. This marks the fourth consecutive year for this ... Sisters of the Third Order of St. Francis . , Health data security and ...
(Date:7/30/2015)... ... ... The connection between a healthy head of hair and a feeling of confidence is a ... hair can have a devastating impact on the daily life of a person. From ... consequences of hair loss are not to be taken lightly. , The skilled staff at ...
(Date:7/30/2015)... York, NY (PRWEB) , ... July 30, 2015 ... ... Setria®Glutathione and Sustamine® L-Alanyl-L-Glutamine for people on the go. With no water needed, ... Recovery Chewable as a simple way to get the natural ingredients that may ...
Breaking Medicine News(10 mins):Health News:Mercy College a “My Brother’s Keeper” Community 2Health News:Mercy College a “My Brother’s Keeper” Community 3Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 2Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 3Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 4Health News:OSF HealthCare Named One of the Most Wired Systems 2Health News:OSF HealthCare Named One of the Most Wired Systems 3Health News:New Study Shows the Link between Hair Restoration and Healthy Self-Image 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 3Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 4
... with cancer, the side effects of chemotherapy and ... drug-delivery research based on nano- and microtechnology from ... well as more effective cancer treatment. , New ... of Tel Aviv University,s Department of Biochemistry allows ...
... Perot Systems receives top ranking in Revenue Cycle Management ... -- For the second consecutive year, Perot Systems ... has received the #1 ranking in several categories of ... to the 2008 survey results, Perot Systems, Revenue ...
... A new analysis from the JUPITER study presented today ... California describes details of the stroke data according to ... adds to the primary analysis of the JUPITER study ... the risk of stroke by nearly half (48%; p=0.002), ...
... Create National Patient Registry, Increase Public Awareness of ... for Pulmonary Fibrosis (CPF) is excited to announce ... (PF) advocacy program -- the introduction of the ... in the 111th Congress. The PFREA, H.R. 1079, ...
... DALLAS, Feb. 19 Cholesterol-lowering statins, used by ... may falsely indicate thyroid problems, according to researchers ... studies, low serum TSH, and the influence of ... ."These findings could help physicians make quicker, more ...
... of Illinois reveals how a cellular protein recognizes an invading ... The research, described this week in the journal Science ... Medical Institute investigator Taekjip Ha, settles a debate over how ... viral RNA and self (or cellular) RNA. , "RIG-I ...
Cached Medicine News:Health News:New 'bubble' targets only cancer cells 2Health News:Perot Systems Ranked #1 Revenue Cycle Manager by Healthcare Providers 2Health News:Perot Systems Ranked #1 Revenue Cycle Manager by Healthcare Providers 3Health News:CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study 2Health News:CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study 3Health News:CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study 4Health News:Pulmonary Fibrosis Research Enhancement Act of 2009 Introduced in 111th U.S. Congress 2Health News:Pulmonary Fibrosis Research Enhancement Act of 2009 Introduced in 111th U.S. Congress 3Health News:Pulmonary Fibrosis Research Enhancement Act of 2009 Introduced in 111th U.S. Congress 4Health News:Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems 2Health News:Team learns how cellular protein detects viruses and sparks immune response 2
(Date:7/30/2015)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ... the patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded ... the notice it received on May 21, 2015 from ... Company was below certain of the Exchange,s continued listing ... of the NYSE MKT Company Guide, due to the ...
(Date:7/30/2015)... COTTAGE, New York , July 30, 2015 /PRNewswire/ ... release of its latest report titled, "Continuous Glucose Monitoring ... - 2020". According to the report, the global continuous ... Mn in 2014 and is expected to reach US$ ... during the forecast period, 2015 to 2020. ...
(Date:7/30/2015)... MIAMI , July 30, 2015   ... latest update to UNI®, the world,s first operating ... simulators, is now available exclusively to Gaumard users. ... for recently launched Newborn Tory™ S2200, as well ... and monitoring of clinical measures such as EtCO ...
Breaking Medicine Technology:TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4Gaumard's Latest UNI Operating System Update Adds Performance and New Functionality 2Gaumard's Latest UNI Operating System Update Adds Performance and New Functionality 3
... N.J., Jan. 18, 2011 Fenwal, Inc. of Lake ... they have signed an agreement under which Fenwal will ... blood centers, plasma centers and hospitals in the United ... such as Genesis™ blood collection mixers and monitors, RapidSeal ...
... Inc. announced today that the U.S. Food & ... clearance to market the SImmetry™ Sacroiliac Joint Fusion ... intended for treating conditions including degenerative sacroiliitis and ... System consists of a range of threaded, cannulated ...
Cached Medicine Technology:Fenwal, GenesisBPS Enter Agreement for Blood-Specialty Products 2Zyga Technology, Inc. Receives FDA 510(K) Clearance for the SImmetry™ Sacroiliac Joint Fusion System 2
... pacing wire design offers reliable ... in the atrium and ventricle ... in one lead design. The ... ventricle are color-coded for easy ...
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
Medicine Products: