Navigation Links
Correcting sickle cell disease with stem cells
Date:9/28/2011

patient's bone marrow cells. After generating induced pluripotent stem (iPS) cells -- adult cells that have been reprogrammed to behave like embryonic stem cells -- from the bone marrow cells, they put one normal copy of the hemoglobin gene in place of the defective one using genetic engineering techniques.

The researchers sequenced the DNA from 300 different samples of iPS cells to identify those that contained correct copies of the hemoglobin gene and found four. Three of these iPS cell lines didn't pass muster in subsequent tests.

"The beauty of iPS cells is that we can grow a lot of them and then coax them into becoming cells of any kind, including red blood cells," Cheng said.

In their process, his team converted the corrected iPS cells into immature red blood cells by giving them growth factors. Further testing showed that the normal hemoglobin gene was turned on properly in these cells, although at less than half of normal levels. "We think these immature red blood cells still behave like embryonic cells and as a result are unable to turn on high enough levels of the adult hemoglobin gene," explains Cheng. "We next have to learn how to properly convert these cells into mature red blood cells."

Only one drug treatment has been approved by the FDA for treatment of SCD, hydroxyurea, whose use was pioneered by George Dover, MD, the chief of pediatrics at the Johns Hopkins Children's Center. Outside of bone marrow transplants, frequent blood transfusions and narcotics can control acute episodes.


'/>"/>
Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Sickle cell trait is not risk factor for kidney disease
2. Schools failing pupils with sickle cell disease
3. Nitric oxide impacts source of sickle cell pain crisis
4. ENERCA clinical recommendations for sickle cell disease management and prevention in children
5. Young black athletes with sickle cell trait might be susceptible to sudden death
6. Sickle Cell May Be Hidden Danger to Young Athletes
7. 2 studies provide insight into stroke risk and prevention in young sickle cell anemia patients
8. Georgia Tech hosts sickle cell disease symposium
9. Sickle cell treatment developed at LA BioMed enters Phase 3 clinical trial
10. Sickle cell patients should be better monitored for constipation prevention
11. Stroke prevention study in children with sickle cell anemia, iron overload stopped early
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2013)... Michigan-based natural health and wellness coach ... R Hamilton which revealed that performing random acts of ... the release of the feel-good hormone Oxytocin in the ... as the ‘cardio protective’ hormone because it temporarily lowers ... health. , “Being kind is something we can all ...
(Date:6/20/2013)... KS (PRWEB) June 20, 2013 The ... launch of its new, online Master of Science ... Essentials of Master’s Education in Nursing from the American ... eventually become the foundation of most major nursing master’s ... in Nursing program from the University of Saint Mary ...
(Date:6/19/2013)... June 20, 2013 Shreya Rangarajan of ... global youth summit on the future of medicine. ... the Global Youth Summit on the Future of Medicine ... Country School and the state of Maryland at the ... will practice in an environment hard to imagine just ...
(Date:6/19/2013)... NC (PRWEB) June 19, 2013 As ... has partnered with Brookstone Lodge on some summertime packages. ... or locals are looking for a fun staycation, we ... fun for couples and families. Asheville is so beautiful ... enjoy, so having several options that guests can choose ...
(Date:6/19/2013)... Scottsdale, AZ (PRWEB) June 19, 2013 Are ... could be losing clients to the competition. , Social ... sales at your massage practice. , Included in your ... into an effective tool in building awareness and revenue for ... now over 5.5 million Twitter users worldwide. Many of these ...
Breaking Medicine News(10 mins):Health News:Kindness Can Be Good for The Heart Says BioGirl Health Show 2Health News:Kindness Can Be Good for The Heart Says BioGirl Health Show 3Health News:University of Saint Mary Launches New Online Master of Science in Nursing Built on the Latest AACN Essentials 2Health News:University of Saint Mary Launches New Online Master of Science in Nursing Built on the Latest AACN Essentials 3Health News:Global Youth Summit on The Future of Medicine-Shreya Rangarajan selected to represent Roland Park Country School and The State of Maryland 2Health News:Global Youth Summit on The Future of Medicine-Shreya Rangarajan selected to represent Roland Park Country School and The State of Maryland 3Health News:Fun Depot Partners with Brookstone Lodge on Summer Packages 2Health News:If Your Massage Practice Isn’t Tweeting, It Isn’t Generating New Sales: 3 Ways Twitter Helps Grow Massage Practices from Appointment-Plus 2
... 30 Worksite wellness programs are a proven ... cardiovascular disease, according to a policy statement published ... Heart Association . These risk factors include smoking, ... diabetes. , To view the Multimedia News Release, ...
... medical costs and ups productivity, heart experts say , ... are an effective way to reduce major risk factors ... pressure and diabetes, says a new American Heart Association ... the United States about $304.6 billion, the association says. ...
... ON People who suffer from debilitating neuropathic pain ... two commonly-prescribed drugs. A new, federally-funded study ... drugs together is a more effective treatment than taking ... anti-seizure drug (gabapentin) and an antidepressant (nortriptyline), patients suffering ...
... ... hosted a press briefing on this study on September 29 at 1:00 p.m. ET. , ... , , ,Philadelphia, PA ... biology of disease, including breast cancer, and lead to significant differences in health outcome, according ...
... ... Club® is inviting all tailgating aficionados to grab a video camera and show the world ... , ... 30, 2009 -- http://www2.samsclub.com/tailgatechallenge , , , , ,It,s Simple - Upload to win ...
... WASHINGTON, Sept. 30 National leaders are meeting in ... conference Oct. 6-7 to urge Congress to support healthcare ... as two of the nation,s largest populations -- baby ... , Congressional and local decision-makers, experts and academic leaders ...
Cached Medicine News:Health News:Video: Worksite Wellness Programs Lower Healthcare Costs, Make Employees Healthier 2Health News:Video: Worksite Wellness Programs Lower Healthcare Costs, Make Employees Healthier 3Health News:Video: Worksite Wellness Programs Lower Healthcare Costs, Make Employees Healthier 4Health News:Workplace Wellness Seems to Really Work 2Health News:Chronic pain treatments work better together, says anesthesiologist 2Health News:Lack of Social Interaction Affects Health Outcomes of Breast Cancer --Stress from loneliness leads to increased tumor growth, Decrease breast cancer risk by increasing social interaction 2Health News:Lack of Social Interaction Affects Health Outcomes of Breast Cancer --Stress from loneliness leads to increased tumor growth, Decrease breast cancer risk by increasing social interaction 3Health News:Lack of Social Interaction Affects Health Outcomes of Breast Cancer --Stress from loneliness leads to increased tumor growth, Decrease breast cancer risk by increasing social interaction 4Health News:Sam's Club Tailgate Challenge Video Contest: Show Sam's Club Your Best Tailgating Style for a Chance To Win a $1,000 Gift Card 2Health News:Sam's Club Tailgate Challenge Video Contest: Show Sam's Club Your Best Tailgating Style for a Chance To Win a $1,000 Gift Card 3Health News:National Hispanic Council on Aging Urges Healthcare Reform and Geriatrics Training for Health Professionals as Older Americans Reach 20% of Population 2Health News:National Hispanic Council on Aging Urges Healthcare Reform and Geriatrics Training for Health Professionals as Older Americans Reach 20% of Population 3
(Date:6/19/2013)... 2013 /PRNewswire-iReach/ -- Robert M. Bernstein, M.D., ... procedures and founder of Bernstein Medical – Center ... Doctors, issue of New York Magazine for the ... ) Dr. Bernstein earned his ... reputation as world-renowned hair restoration physician, through a ...
(Date:6/19/2013)... -- The American Association for Homecare (AAHomecare), along with a ... announced today the filing of a lawsuit in ... asking that the scheduled July 1 expansion of the Medicare ... stopped because of serious licensing irregularities. The lawsuit ... Secretary Kathleen Sebelius as the defendant. HHS oversees ...
(Date:6/19/2013)... June 19, 2013 ... market research report is available in ... Licensing, Investments and M&A Deals and ... http://www.reportlinker.com/p0925641/Partnerships-Licensing-Investments-and-MA-Deals-and-Trends-for-May-2013-in-Pharmaceuticals.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Investment_Banking ... Deals and Trends for May 2013 ...
Breaking Medicine Technology:Dr. Robert Bernstein in NY Magazine's 'Best Doctors' Issue for 14th Consecutive Year 2Dr. Robert Bernstein in NY Magazine's 'Best Doctors' Issue for 14th Consecutive Year 3AAHomecare and Maryland DME Provider Take Medicare Agency to Court Over Competitive Bidding Program 2AAHomecare and Maryland DME Provider Take Medicare Agency to Court Over Competitive Bidding Program 3AAHomecare and Maryland DME Provider Take Medicare Agency to Court Over Competitive Bidding Program 4AAHomecare and Maryland DME Provider Take Medicare Agency to Court Over Competitive Bidding Program 5Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 2Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 3Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 4Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 5Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 6Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 7Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 8Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 9Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 10Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 11Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 12Partnerships, Licensing, Investments and M&A Deals and Trends for May 2013 in Pharmaceuticals 13
... PORTOLA VALLEY, Calif. , May 3 Spectros ... Koninklijke Philips Electronics N.V. ( PHG). Under this agreement, Philips purchased ... first developed and patented by Spectros. , ... "We are pleased that Philips has recognized ...
... , AMSTERDAM , May 3, ... manufacturer, has expanded its current,agreement with OncoMed Pharmaceuticals, Inc., a company ... in,addition to antibody OMP-21M18, SynCo will fill batches of OncoMed,s,investigational products, ... and II clinical trials. , ...
Cached Medicine Technology:Spectros Corp. Enters Into Optical Biotechnology Patent Sale Agreement With Philips Electronics N.V. 2SynCo Expands Agreement with OncoMed Pharmaceuticals to Manufacture Cancer Stem Cell Antibodies 2SynCo Expands Agreement with OncoMed Pharmaceuticals to Manufacture Cancer Stem Cell Antibodies 3
0.12 mm, 1 x 2 teeth set at 45 degrees with 5 mm tying platform. Serrated handle with polished finish....
Serrated handle with 7 mm tying platform and polished finish. Teeth: 0.25 mm, 2 x 2 set at 45 degrees....
5 mm tying platform, serrated cross action handle with polished finish. Teeth: 0.10 mm, 1 x 2 set at 45 degrees....
0.12 mm, 1 x 2 teeth set at 45 degrees with 6 mm tying platform. Wide serrated handle with polished finish....
Medicine Products: