Navigation Links
Coronary imaging enhances ability to identify plaques likely to cause future heart disease
Date:1/20/2011

NEW YORK, NY JANUARY 20, 2011 Results from the PROSPECT clinical trial shed new light on the types of vulnerable plaque that are most likely to cause sudden, unexpected adverse cardiac events, and on the ability to identify them through imaging techniques before they occur.

The trial, Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT), is the first prospective natural history study of atherosclerosis using multi-modality imaging to characterize the coronary tree. The study findings were published in the January 20, 2011 issue of the New England Journal of Medicine.

"As a result of the PROSPECT trial, we are closer to being able to predictand therefore prevent sudden, unexpected adverse cardiac events," said principal investigator Gregg W. Stone, MD. Dr. Stone is Professor of Medicine at Columbia University College of Physicians and Surgeons, Director of Cardiovascular Research and Education at the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center and Co-Director of the Medical Research and Education Division at the Cardiovascular Research Foundation (CRF).

The multi-center trial studied 700 patients with acute coronary syndromes (ACS) using three-vessel multimodality intra-coronary imaging angiography, grayscale intravascular ultrasound (IVUS), and radiofrequency IVUS to quantify the clinical event rate due to atherosclerotic progression and to identify those lesions that place patients at risk for unexpected adverse cardiovascular events (sudden death, cardiac arrest, heart attacks and unstable or progressive angina).

Among the discoveries of the trial are that most untreated plaques that cause unexpected heart attacks are not mild lesions, as previously thought, but actually have a large plaque burden and/or a small lumen area. These are characteristics that were invisible to the coronary angiogram but easily identifiable by grayscale IVUS.

Moreover, and perhaps most importantly, for the first time it was demonstrated that characterization of the underlying plaque composition (with radiofrequency IVUS, also known as VH-IVUS) was able to significantly improve the ability to predict future adverse events beyond other more standard imaging techniques.

"These results mean that using a combination of imaging modalities, including IVUS to identify lesions with a large plaque burden and/or small lumen area, and VH-IVUS to identify a large necrotic core without a visible cap (a thin cap fibroatheroma) identifies the lesions that are at especially high risk of causing future adverse cardiovascular events," Dr. Stone said.

Results of the trial were first reported at the 2009 Transcatheter Cardiovascular Therapeutics (TCT) annual scientific symposium, sponsored by CRF.


'/>"/>

Contact: Irma Damhuis
idamhuis@crf.org
646-434-4690
Cardiovascular Research Foundation
Source:Eurekalert

Related medicine news :

1. New research shows innovative respiratory stress test can quickly detect significant coronary artery disease in a noninvasive setting
2. Family history is strong predictor of obstructive coronary artery disease using CCTA
3. Mass. General Hospital to create registry for coronary optical coherence tomography
4. Coronary CTA a cost-effective alternative to cardiac catheterization for the evaluation of CAD
5. The Mount Sinai Hospital Earns Highest Ratings in New York State Report on Coronary Angioplasty
6. New research shows cardiologists can quickly detect significant coronary artery disease using a non-invasive simple, short respiratory stress test
7. Link established between erectile dysfunction and calcified coronary arteries
8. Carotid artery ultrasound is an effective alternative to more invasive coronary angiography
9. New tool to rule out coronary heart disease in primary care
10. Dietary Cocoa Flavanols Improve Vascular And Blood Pressure Measures For Coronary Artery Disease Patients
11. Lower-dose heparin use during coronary procedure does not appear to reduce risk of major bleeding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 24, 2017 , ... Accordant Technology, a trusted IT solutions ... an analytics-first approach, layered with machine learning, that provides real-time visibility into the ... cloud to the edge. Through the new partnership, customers get the real-time situational ...
(Date:5/24/2017)... ... May 24, 2017 , ... Fiberstar, Inc., ... the food and beverage industry offers Citri-Fi®, a natural citrus fiber, to improve ... decision process. As a result, labels need to deliver simple, transparent and clear ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Allegheny Health ... open The Alexis Joy D’Achille Center for Women’s Behavioral Health at West Penn ... in western Pennsylvania for women suffering from pregnancy-related depression. Construction of the Center ...
(Date:5/23/2017)... , ... May 23, 2017 , ... ... body for exercise professionals, is pleased to announce the organization’s Certified Strength Coach ... The NCSF Certified Strength Coach (CSC) program validates the competency of qualified candidates ...
(Date:5/23/2017)... York (PRWEB) , ... May 23, 2017 , ... ... LifeLabs, a leading equipment provider in the modern ART laboratory, to provide hands-on ... in Ft. Lauderdale, Florida. , NextGen LifeLabs, a MedTech Group Purchasing vendor ...
Breaking Medicine News(10 mins):
(Date:5/23/2017)...  Leaf Healthcare, recognized for developing one of ... ulcer prevention, will unveil its comprehensive mobility monitoring ... Nurses, National Teaching Institute and Critical Care Exposition ... Patient Monitoring System is the first mobility monitoring ... system seamlessly tracks patient movement throughout the mobility ...
(Date:5/15/2017)... May 15, 2017  Amy Baxter MD, chief executive ... in noninvasive pain relief, was awarded a 2017 Top ... Baxter was recognized at the MM&M Top 40 Healthcare ... City on May 10, 2017. The dinner ... industry go "beyond the pill."  "Innovation goes ...
(Date:5/10/2017)... Global Health Intelligence (GHI), the leading healthcare data analytics ... 2017 ranking of the Best-Equipped Hospitals in Latin America ... GHI,s hospitals database for Latin America , which is ... database covers 86% of the hospitals in Latin ... each institution in key areas such as beds, medical specialties, ...
Breaking Medicine Technology: