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Coronary Artery Calcium May Raise Women's Heart Risk
Date:12/10/2007

New study challenges traditional assessment of risk

MONDAY, Dec. 10 (HealthDay News) -- About 5 percent of women considered at low risk for heart disease still face potential cardiovascular problems because of calcium buildup in their arteries, a new study suggests.

"Previous studies have demonstrated that calcium is predictive of coronary artery disease in other populations," said study lead author Dr. Susan G. Lakoski, a cardiology fellow at the Wake Forest University School of Medicine. "We traditionally have the question of looking at low-risk people."

The standard method of measuring heart risk is the so-called Framingham risk score, which is based on findings of a decades-long study of residents of a Massachusetts town. The score includes such factors as age, cholesterol levels, diabetes, smoking and obesity, but not calcium.

Lakoski and her colleagues used computerized tomography scans of the chest to measure coronary artery calcium in 3,601 women between 45 and 84 years of age. Ninety percent of the women were considered "low risk," because their Framingham scores indicated they had less than a 10 percent chance of a cardiac event in 10 years. (High risk is a test score of 20 percent or higher.)

Over an average of the next 3.75 years, 24 of the low-risk women had heart events -- such as heart pain or a heart attack -- and 34 of the women had a so-called cardiovascular disease event, including heart events, stroke or death, the study found.

Women with the highest calcium scores were especially at risk, Lakoski said. "They had an 8.6 percent risk of a coronary event," she said.

The findings are published in the Dec. 10/24 issue of Archives of Internal Medicine.

Lakoski said it's probably too early to consider routine testing of coronary artery calcium to gauge heart risk for women. The number of study participants was small, and further research is needed, she s
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