Navigation Links
Cooling may prevent trauma-induced epilepsy
Date:2/21/2013

In the weeks, months and years after a severe head injury, patients often experience epileptic seizures that are difficult to control. A new study in rats suggests that gently cooling the brain after injury may prevent these seizures.

"Traumatic head injury is the leading cause of acquired epilepsy in young adults, and in many cases the seizures can't be controlled with medication," says senior author Matthew Smyth, MD, associate professor of neurological surgery and of pediatrics at Washington University School of Medicine in St. Louis. "If we can confirm cooling's effectiveness in human trials, this approach may give us a safe and relatively simple way to prevent epilepsy in these patients."

The researchers reported their findings in Annals of Neurology.

Cooling the brain to protect it from injury is not a new concept. Cooling slows down the metabolic activity of nerve cells, and scientists think this may make it easier for brain cells to survive the stresses of an injury.

Doctors currently cool infants whose brains may have had inadequate access to blood or oxygen during birth. They also cool some heart attack patients to reduce peripheral brain damage when the heart stops beating.

Smyth has been exploring the possibility of using cooling to prevent seizures or reduce their severity.

"Warmer brain cells seem to be more electrically active, and that may increase the likelihood of abnormal electrical discharges that can coalesce to form a seizure," Smyth says. "Cooling should have the opposite effect."

Smyth and colleagues at the University of Washington and the University of Minnesota test potential therapies in a rat model of brain injury. These rats develop chronic seizures weeks after the injury.

Researchers devised a headset that cools the rat brain. They were originally testing its ability to stop seizures when they noticed that cooling seemed to be not only stopping but also preventing seizures.

Scientists redesigned the study to focus on prevention. Under the new protocols, they put headsets on some of the rats that cooled their brains by less than 4 degrees Fahrenheit. Another group of rats wore headsets that did nothing. Scientists who were unaware of which rats they were observing monitored them for seizures during treatment and after the headsets were removed.

Rats that wore the inactive headset had progressively longer and more severe seizures weeks after the injury, but rats whose brains had been cooled only experienced a few very brief seizures as long as four months after injury.

Brain injury also tends to reduce cell activity at the site of the trauma, but the cooling headsets restored the normal activity levels of these cells.

The study is the first to reduce injury-related seizures without drugs, according to Smyth, who is director of the Pediatric Epilepsy Surgery program at St. Louis Children's Hospital.

"Our results show that the brain changes that cause this type of epilepsy happen in the days and weeks after injury, not at the moment of injury or when the symptoms of epilepsy begin," says Smyth. "If clinical trials confirm that cooling has similar effects in humans, it could change the way we treat patients with head injuries, and for the first time reduce the chance of developing epilepsy after brain injury."

Smyth and his colleagues have been testing cooling devices in humans in the operating room, and are planning a multi-institutional trial of an implanted focal brain cooling device to evaluate the efficacy of cooling on established seizures.


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert  

Related medicine news :

1. Cooling Helps Oxygen-Deprived Newborns: Study
2. Heroes of Chemistry: Developed new drugs and technology to cut heating and cooling bills
3. Delta Cooling Towers extends Industry Leading Warranty to 20 Years
4. Study of brain cooling and clot-busting drug therapy for stroke receives FDA OK to expand
5. New drug prevents spread of human prostate cancer cells
6. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
7. To prevent leukemias dreaded return, go for the stem cells
8. Rapid Asthma Treatment in ER May Prevent Admission
9. Report says new evidence could tip the balance in aspirin cancer prevention care
10. Drug May Prevent Pancreatitis After Digestive Procedure
11. Decision guide reduced uncertainty over breast cancer prevention, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cooling may prevent trauma-induced epilepsy
(Date:5/6/2016)... , ... May 06, 2016 , ... ... AsedaSciences® in an upcoming episode, airing third quarter 2016, via Discovery Channel. Dates ... of becoming a leader in optimized drug discovery through innovative cellular analysis. In ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... ... does to reduce fat areas around the body, is the most popular among ... results just released make perfect sense to cosmetic surgeon Dr. Richard Buckley, medical ...
(Date:5/6/2016)... Grants Pass, OR (PRWEB) , ... May 06, 2016 , ... ... the eyes. In other seasons, when the weather is too cold, dry or hot, ... weather, the eyes can actually absorb moisture from the surrounding air. There’s only one ...
(Date:5/6/2016)... ... May 06, 2016 , ... Online HR/benefits platforms offer a range ... game for traditional brokers and health plans. “ The Rapid Emergence of Online Benefits ... Atlantic Information Services, Inc. (AIS), will offer an accurate picture of online benefits today, ...
(Date:5/6/2016)... ... May 06, 2016 , ... From May 4 to 6, ... members the unique opportunity to learn more about Signia’s technology and the successful business ... “It is our priority to see practices succeed in this highly competitive industry,” said ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 6, 2016 ... of liver disorders along with rise in obesity ... drugs in the coming few years. The NASH ... last five years on account of rising number ... is a large, un-tapped market with no FDA ...
(Date:5/5/2016)... -- Replikins Ltd. today reported initial promising results in animal trials of its Zika vaccine ... ... ... ... on Pubmed. The analysis identified the highest gene Replikin Counts in Zika history back ...
(Date:5/5/2016)...  Endo International plc (NASDAQ: ENDP ... Lortie , President, U.S. Branded Pharmaceuticals, has decided ... appointment of a successor. Mr. Lortie joined Endo ... with responsibility for all strategic, commercial and operational ... development, commercial operations, managed markets, manufacturing, supply chain ...
Breaking Medicine Technology: