Navigation Links
'Cooling' Helps Oxygen-Deprived Newborns: Study
Date:5/30/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, May 30 (HealthDay News) -- Children who suffered from a lack of oxygen during birth and who received whole-body cooling fared better than those who weren't given the treatment, a new study shows.

Although rare, the condition can result in brain damage and death. However, putting infants into a state of hypothermia by temporarily lowering their body temperature seems to help the brain repair itself, the researchers report.

"Children [who were] cooled at birth, at 6 to 7 years of age had a lower frequency of death or IQ below 70," said lead researcher Dr. Seetha Shankaran, director of neonatal/perinatal medicine and a distinguished professor of pediatrics at Wayne State University School of Medicine, in Detroit.

The researchers noted that the difference in IQ was not statistically significant, but the survival difference was.

"There was protection of the brain from lack of oxygen and lack of blood flow by hypothermia from the time the infants were born all the way through to 6 to 7," Shankaran said.

The risk of death or disability was greatest among those who had the most initial damage, she added.

"Cooling is not completely protective, but among children who had moderate injury, the incidence of low IQ was only 47 percent, compared to 62 percent of the controls," she said.

"Cooling is now being practiced throughout the United States and we can be reassured that the benefits are seen in infancy are going to persist," Shankaran added.

Oxygen deprivation during birth, also known as neonatal hypoxic-ischemic encephalopathy, occurs in roughly one in every 1,000 births in the United States. It can result when the umbilical cord becomes wrapped around the infant's neck or if it is pinched by the infant's shoulder, among other causes. This cuts off circulation of oxygen and blood to the infant and results in damage to the brain and other organs.

Cooling slows down the metabolic processes of the body and prevents toxins from causing more damage while allowing the body to heal, Shankaran explained.

The report was published in the May 31 issue of the New England Journal of Medicine.

This study is a follow-up to an earlier study that found cooling reduced the rate of deaths and disability in infants when they were 18 to 22 months old.

In the new trial, 208 children with the condition were randomly assigned to cooling or not within six hours after birth.

Those cooled had their body temperature reduced to around 92 F for three days and then slowly rewarmed.

The children were evaluated again when they were 6 and 7 years old. The researchers looked specifically for deaths and IQs below 70.

The researchers found that for the 190 children for whom data were available, 47 percent in the cooling group had IQs below 70, compared with 62 percent among those who were not cooled.

Among those who had been cooled, 28 percent had died, compared with 44 percent of those who hadn't, they found.

Moreover, either death or severe disability occurred in 41 percent of those cooled, but in 60 percent of those not cooled, the researchers noted.

Dr. Howard Heiman, associate chief of the neonatal intensive care unit at Cohen Children's Medical Center of New York, said that "we know that brain cooling offers about a 15 percent improved chance to have a good outcome."

"But, we were worried that a good outcome in the short term, in the long term there would be hidden damage. We have a big sigh of relief that we are not causing more damage," he said.

Cooling is "not a silver bullet, but it gives us an edge without worsening the chances of bad survival," Heiman said.

More information

For more information on birth defects, visit the U.S. National Library of Medicine.

SOURCES:Seetha Shankaran, M.D., director, neonatal/perinatal medicine, distinguished professor, pediatrics, Wayne State University School of Medicine, Detroit;Howard Heiman, M.D., associate chief, neonatal intensive care unit, Cohen Children's Medical Center of New York, New Hyde Park; May 31, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Fever control using external cooling reduces early mortality in septic shock patients
2. Mayo Clinic study guides physicians using therapeutic cooling to treat cardiac arrest patients
3. Coordinated Cooling Effort After Cardiac Arrest Can Improve Outcomes
4. Cooling system may build eggs natural defenses against salmonella
5. Sleeptime Head-Cooling Cap Eases Insomnia, Study Finds
6. Cooling the brain during sleep may be a natural and effective treatment for insomnia
7. Cooling may benefit children after cardiac arrest
8. Colorful brains, cooling lasers, disease-detecting lights and more
9. Cooling inflammation for healthier arteries
10. Breast MRI helps predict chemotherapys effectiveness
11. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Cooling' Helps Oxygen-Deprived Newborns: Study
(Date:6/23/2017)... ... 23, 2017 , ... The Katyl Agency, a locally owned ... business owners in and around Lackawanna County, is joining Meals On Wheels of ... , Meals on Wheels of NEPA provides hand-delivered and nutritious meals to seniors ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, ... area with access to asset protection and financial planning services, is teaming up ... improving the lives of children with cancer and other chronic diseases. , The ...
(Date:6/22/2017)... ... June 22, 2017 , ... Groove Ring is excited to announce they've ... performance silicon wedding bands and all-purpose rings. Whether you’re an athlete, adventurer, professional, or ... just for you. , From the rock face to the auto shop, Groove Ring ...
(Date:6/22/2017)... ... 2017 , ... Vighter, a premier provider of Unconventional Medical ... PSC.1-2012. The company’s work in countries throughout Southwest Asia, South America, and the ... degraded. The PSC.1 standard was created to protect fundamental freedoms and human rights ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... Texas-based health system, will present how predictive analytics drive reimbursement optimization, with a ... in Orlando, June 25-28. , “The traditional approach to denied and underpaid ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... -- In 2016, Embodied Labs took top prize ... came away with $25,000 in seed-fund investment. Embodied Labs ... "entering the life of another" and by the Journal ... medical professionals in an entirely new dimension." Building upon ... for the Department of Education,s EdSimChallenge, where they received ...
(Date:6/10/2017)...  Shane K. Burchfield, DPM, is recognized by Continental Who,s Who ... in Alabama . Dr. Burchfield ... He brings over 20 years of experience, as well as expertise ... his role. "The ... to welcome you to his practice," the company,s website ...
(Date:6/8/2017)... June 8, 2017   Responding to Heath Ledger,s ... the death of singer Chris Cornell in May, ... International offers a free online psychiatric drug ... and families about psychotropic drug risks. The ... died from an accidental overdose, has called for tighter rules ...
Breaking Medicine Technology: