Navigation Links
'Cool' New Treatment for Hot Flashes in Breast Cancer Survivors
Date:5/14/2008

Study shows marked reduction in frequency, severity of hot flashes and

sleep disturbances using neural block

CHICAGO, May 14 /PRNewswire/ -- An anesthetic injection into a collection of nerves in the neck of breast cancer survivors may reduce the severity and frequency of debilitating hot flashes and night awakenings associated with breast cancer treatment, according to a new study published online today by The Lancet Oncology and appearing in its June issue.

Hot flashes and sleep dysfunctions often plague breast cancer survivors, especially those who take anti-estrogen medications. Conventional treatments have been only partially effective and may carry serious risks. Previous research has shown that hot flashes experienced by breast cancer survivors are significantly more frequent, severe, and of greater duration than those in menopausal women.

Eugene G. Lipov, MD, and Jaydeep R. Joshi, MD, of Advanced Pain Centers, Hoffman Estates (Chicago), Ill., and co-authors, conducted a pilot study of the safety and efficacy of the stellate ganglion block in 13 breast cancer survivors. It is called a "stellate" block as it describes the star-shaped collection of nerves in the neck which regulates body temperature and therefore may affect quality of sleep. The block, used by practitioners for over 60 years, is an injection of a numbing solution near the C6 vertebrae that can be performed under either local anesthesia or with "twilight" sedation. The injection is given with the aid of fluoroscopy (guided X-ray) to ensure correct and safe placement of the needle. The procedure takes approximately 10 minutes to perform in an outpatient setting.

"Estrogen-depleting drugs used in the fight against breast cancer often leave women's bodies defenseless against debilitating hot flashes and the sleep disturbances they cause," says Dr. Lipov. "This small pilot study conducted in breast cancer survivors confirms our earlier research on healthy menopausal women that the stellate ganglion block can effectively 'shut off' these troubling symptoms. Since these symptoms are generally more severe in women who have undergone breast cancer treatment, the block is a significant arsenal in helping estrogen-depleted women feel better with few or no side effects."

Women on hormone replacement therapy were excluded from the study. The 13 study patients were 30 to 70 years of age (mean age, 53 years). Four of the 13 patients had been diagnosed with Stage 0 breast cancer (or infiltrating ductal carcinoma in situ, the earliest, and noninvasive, cancer stage), 4 had Stage 1 cancer, 4 had Stage 2, and 1 had Stage 3. Using two standardized measures, each patient recorded the severity and intensity of her hot flashes and the number of night awakenings for 1 week before the procedure and weekly for 12 weeks postprocedure. The investigators applied a statistically-sound estimating equation to analyze the number of hot flashes and night awakenings over time.

If the effect of the stellate ganglion block on hot flashes and night awakenings did not last throughout the 12-week study period, the block was repeated. The decision to repeat the block was made by the patient if she felt her symptoms were returning. (Multiple blocks have been used for decades without increased risk.) Of the 13 women, 5 had only 1 stellate ganglion block and 8 women had 2 blocks. Women who had 2 blocks generally reported more lasting relief of symptoms than after the first procedure.

The total number of hot flashes decreased from a mean of 79.4 per week before the procedure to a mean of 49.9 per week during the first 2 weeks after the treatment. After 2 weeks, the total number of hot flashes continued to decline and stabilized at 8.1 per week from weeks 3 through 12. The severity of the hot flashes similarly decreased, with the most dramatic drop-off in severity occurring within 1 day to 1 week after treatment; the rate of "very severe" flashes remained near zero for the remainder of the follow-up period. The total number of night awakenings decreased by about two-thirds within 2 weeks after treatment, from 19.5 per week before the block to 7.3 per week afterwards. This number continued to decline throughout the follow-up period and stabilized at 1.4 per week. All results were highly statistically significant.

"Hot flashes are a frequent and serious side effect of pharmacological treatments for breast cancer. They may even contribute to cancer recurrence by discouraging compliance with treatment regimens, as 50% of these patients may become noncompliant after 6 months," Dr. Joshi explains. "Long-term relief of symptoms has the potential to improve overall quality of life and increase compliance with anti-estrogen medications for breast cancer."

Disclosure statement: This study was self-funded and no sponsorship is declared.

To contact Dr. Lipov and/or his coauthors please call Patti Davis, MPH, of DAVIS MEDPR, Inc. at 630.920.8042 (CT) or email patti@davismedpr.com. More information on the stellate block is available at http://www.hotflashescure.com. Dr. Lipov is fluent in Russian. Further information on Drs. Lipov and Joshi and Advanced Pain Centers can be found at http://www.painmngt.com.


'/>"/>
SOURCE DAVIS MEDPR, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Cool new treatment for hot flashes in breast cancer survivors
2. Cardium Announces InnerCools Endovascular Cooling to be Featured on Science Channels Series Cool Stuff: How It Works
3. CoolTouch Introduces CoolBlue Duet(TM) Laser Lipolysis Suction Handpiece
4. Studies message to women: Keep your cool
5. Cardiums InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems
6. AtriCures Coolrail(TM) Linear Ablation Pen Receives FDA 510(k) Clearance
7. Troubled Boys Will Abandon Pot When Its Deemed Uncool
8. CoolTouch Inc. Responds to Cynosure Patent Infringement Lawsuit
9. Cynosure Files Patent Infringement Lawsuit Against CoolTouch Inc.
10. Better access to cool caps improves outcomes, lowers cost of treating asphyxia in newborns
11. CoolTouch Introduces CoolLipo(TM) Laser System, Recently FDA Cleared for Laser-Assisted Lipolysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... NY (PRWEB) , ... April 28, 2017 , ... It's ... there are a number of illnesses that are unclear as to whether or not ... their heads. Bronchitis is one of these illnesses. So, FindaTopDoc took a look into ...
(Date:4/28/2017)... ... ... affects much more than energy – it also has mental and physical benefits. According to ... time, which can increase the risk of having a car accident. , This week ... to help you sleep better and feel better:, , Turn off ...
(Date:4/28/2017)... ... , ... The Radiology Business Management Association (RBMA) is pleased to ... election process has been in place since the RBMA was founded in 1968 with ... succeeds Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... America (UCAOA) and College of Urgent Care Medicine will host industry leaders for ... and speakers will help those in the industry adapt to the issues currently ...
(Date:4/28/2017)... ... April 28, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... Creator responds to and which He does not. Yisrayl says with so many titles ... the true name, but he says with a little Scripture, backed with a lot of ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... EAST HANOVER, N.J. , April 19, 2017 ... study conducted by the National Heart, Lung, and ... Health (NIH) demonstrating that 58% of patients with ... at six months when treated with eltrombopag at ... treatment 1 . The study evaluated three sequential ...
(Date:4/18/2017)... April 18, 2017  Cardinal Health (NYSE: ... fiscal 2017 earnings per share (EPS) guidance and providing ... is in conjunction with this morning,s announcement of the ... and Nutritional Insufficiency businesses. Cardinal Health now ... will be at the bottom of its previous guidance ...
(Date:4/18/2017)... Viverae ® , a leader in workplace ... IBM ® Watson Campaign Automation, implementing behavioral messaging ... a personalized experience. Through digital engagement, the platform prompts ... real time. The enhanced experience drives engagement by focusing ... they are in their journey to health. ...
Breaking Medicine Technology: