Navigation Links
Controversial TOFT theory of cancer versus SMT model: Authors do battle in BioEssays
Date:4/14/2011

Writing in BioEssays, cancer scientists Ana Soto and Carlos Sonnenschein pit their controversial Tissue Organization Field Theory (TOFT) of the origin of cancer against the widely accepted Somatic Mutation Theory (SMT) in what is believed to be the first time the two theories have formally opposed each other championed by authors from opposite sides of the debate in a common forum for discussion.

Soto and Sonnenschein, from Tufts University, argue that SMT, which is based on the accumulation of genetic mutations in cells, not only fails to provide an explanation for observable phenomena in cancer biology, but with current technologies it is essentially untestable.

The TOFT theory proposes that cancer is a clonal, cell-based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms.

"SMT is strongly supported by observations of leukemias that bear specific chromosome translocations," writes Dr David Vaux, from La Trobe Institute for Molecular Science, Australia, in defence of SMT. "Perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene."

"This appears to be the first time that the TOFT has formally gone head-to-head with the SMT in a common arena" said BioEssays, Editor-in-Chief Andrew Moore.

"BioEssays believes that science advances through the clear exposition of contrary views, and has created a new forum for vigorous debate which addresses the fundamental basis of cancer: may our readers decide for themselves!" adds David Thomas, BioEssays, Editorial Board Member, and co-editor of the Point<>Counterpoint pair.


'/>"/>

Contact: Ben Norman
Lifesciencenews@wiley.com
44-012-437-70375
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Recommendations issued on controversial Ashley procedure for disabled children
2. K-State receives patent for noncontroversial source of stem cells
3. Review Panel Leaves Controversial Lyme Disease Guidelines Unchanged
4. Controversial urological issues top EAUs Anniversary Congress in Barcelona
5. Project Prevention Brings Controversial Sterilization Program to Honolulu
6. Can chaos theory help predict heart attacks?
7. Study Challenges Key Autism Theory
8. Evidence-based medicine theory can be applied to frequent flying says US professor
9. Theory of single stem cell for blood components challenged
10. Nervous System Imbalance May Cause Fatigue in Breast Cancer Survivors
11. Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... ... CertainTeed Corporation, he knew it was something that contractors should have at their ... as it gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As ...
(Date:5/31/2016)... ... ... The successful implementation of “lean manufacturing” in various fields has inspired many businesses ... compared to manufacturing environments. , In order to provide a way to gain ... Lean Lab Checklist . This checklist will help users gain an overview of ...
(Date:5/31/2016)... ... ... Spectrum Aquatics has launched a brand new ADA pool lift, the Motion Trek ... in mind. , “Over the last two years our key customers and designers plus ... is a necessary requirement for certain facilities with specific needs,” said Nabil Khaled, Spectrum ...
(Date:5/31/2016)... ... ... In a recent interview on The Greenburgh Report radio show hosted by ... (1460 AM), leading medical insurance advocate Adria Goldman Gross discussed several eye-opening issues ... , During the interview with Mr. Feiner that aired on May 7, 2016, ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... enterprise focused on patients with cancer, has added Cancer and Careers ... visitors with more timely content on continuing successful careers while fighting cancer. , ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... ALBANY, New York , May 31, 2016 /PRNewswire/ ... and other biomaterials market is progressing at a CAGR ... 2020. This market was valued at US$0.46 bn in ... market, it is expected to reach US$0.88 bn by ... statistical data is derived from the market,s holistic representation ...
(Date:5/31/2016)... 31, 2016 Aloe vera extracts ... cosmetics and pharmaceuticals, with global volume to surpass 60,720.4 ... Bn. Demand for aloe vera extracts for ... will continue its upward momentum in 2016 as well. ... positive sentiment on aloe vera, with wide-ranging applications in ...
(Date:5/31/2016)... -- The global biomaterials market is driven by ... deaths from chronic diseases. According to research report, "Global Biomaterials ... and Forecasts (2016-2021) - (By Value; By Material Type - ... Care); By Region-North America, Europe , APAC, ... , Italy , Japan ...
Breaking Medicine Technology: