Navigation Links
Controversial TOFT theory of cancer versus SMT model: Authors do battle in BioEssays

Writing in BioEssays, cancer scientists Ana Soto and Carlos Sonnenschein pit their controversial Tissue Organization Field Theory (TOFT) of the origin of cancer against the widely accepted Somatic Mutation Theory (SMT) in what is believed to be the first time the two theories have formally opposed each other championed by authors from opposite sides of the debate in a common forum for discussion.

Soto and Sonnenschein, from Tufts University, argue that SMT, which is based on the accumulation of genetic mutations in cells, not only fails to provide an explanation for observable phenomena in cancer biology, but with current technologies it is essentially untestable.

The TOFT theory proposes that cancer is a clonal, cell-based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms.

"SMT is strongly supported by observations of leukemias that bear specific chromosome translocations," writes Dr David Vaux, from La Trobe Institute for Molecular Science, Australia, in defence of SMT. "Perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene."

"This appears to be the first time that the TOFT has formally gone head-to-head with the SMT in a common arena" said BioEssays, Editor-in-Chief Andrew Moore.

"BioEssays believes that science advances through the clear exposition of contrary views, and has created a new forum for vigorous debate which addresses the fundamental basis of cancer: may our readers decide for themselves!" adds David Thomas, BioEssays, Editorial Board Member, and co-editor of the Point<>Counterpoint pair.


Contact: Ben Norman

Page: 1

Related medicine news :

1. Recommendations issued on controversial Ashley procedure for disabled children
2. K-State receives patent for noncontroversial source of stem cells
3. Review Panel Leaves Controversial Lyme Disease Guidelines Unchanged
4. Controversial urological issues top EAUs Anniversary Congress in Barcelona
5. Project Prevention Brings Controversial Sterilization Program to Honolulu
6. Can chaos theory help predict heart attacks?
7. Study Challenges Key Autism Theory
8. Evidence-based medicine theory can be applied to frequent flying says US professor
9. Theory of single stem cell for blood components challenged
10. Nervous System Imbalance May Cause Fatigue in Breast Cancer Survivors
11. Study suggests enzyme crucial to DNA replication may provide potent anti-cancer drug target
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... ... their Black Friday sale a week early, offering 40% off select bras and ... intimate apparel industry through both mobile fit technology and the latest fashion, quickly ...
(Date:11/24/2015)... N.J. (PRWEB) , ... November 25, 2015 , ... ... delivery technologies and development solutions for drugs, biologics, consumer health and global clinical ... will present at the upcoming Clinical Trial Supply East Asia Conference, to be ...
(Date:11/24/2015)... ... 24, 2015 , ... The hospitals and health systems on ... orthopedic care. They have received recognition for excellence from various reputable organizations in ... Becker's Hospital Review selected hospitals for inclusion based on national rankings and awards ...
(Date:11/24/2015)... UT (PRWEB) , ... November 24, 2015 , ... It ... Magazine. For a business, it is critical that the first impression be positive and ... they are not likely to buy anything or want to return. They will also ...
(Date:11/24/2015)... ... November 24, 2015 , ... Brillouin Energy Corp. Congress ... the developer of renewable energy technologies capable of producing commercially useful amounts of ... that its WET™ and HHT™ Boiler System reactor core modules were presented to ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015 Avery Biomedical Devices (ABD), ... to announce the appointment of Anders Jonzon , ... Dr. Jonzon is a ... Children,s Hospital, Uppsala University, Uppsala and Children,s Hospital, Karolinska, ... was a fellow at the Cardiovascular Institute (UCSF). His ...
(Date:11/24/2015)... DALLAS , Nov. 24, 2015  Ascendant Solutions, Inc. ... announced that its Board of Directors has declared a special ... The stock dividend is payable December 14, 2015, to shareholders ... in the form of additional shares of common stock. ... by the Board is a strong endorsement of our confidence ...
(Date:11/24/2015)... st  Scientific Assembly and Annual Meeting of the Radiological Society of ... Chicago on Nov-29 th through Dec-4 th ... Assembly and Annual Meeting of the Radiological Society of ... on Nov-29 th through Dec-4 th , in ... its revolutionary whole body CZT digital SPECT/CT solution at the upcoming ...
Breaking Medicine Technology: