Navigation Links
Controlling vascular disease may be key to reducing prevalence of Alzheimer's disease
Date:11/5/2012

Amsterdam, NL, November 5, 2012 Over the last 15 years, researchers have found a significant association between vascular diseases such as hypertension, atherosclerosis, diabetes type 2, hyperlipidemia, and heart disease and an increased risk of Alzheimer's disease. In a special issue of the Journal of Alzheimer's Disease, leading experts provide a comprehensive overview of the pathological, biochemical, and physiological processes that contribute to Alzheimer's disease risk and ways that may delay or reverse these age-related abnormalities.

"Vascular risk factors to Alzheimer's disease offer the possibility of markedly reducing incident dementia by early identification and appropriate medical management of these likely precursors of cognitive deterioration and dementia," says Guest Editor Jack C. de la Torre, MD, PhD, of the University of Texas, Austin. "Improved understanding coupled with preventive strategies could be a monumental step forward in reducing worldwide prevalence of Alzheimer's disease, which is doubling every 20 years."

The issue explores how vascular disease can affect cerebral blood flow and impair signaling, contributing to Alzheimer's disease (AD). The diagnostics of cardiovascular risk factors in AD are addressed, as are potential therapeutic approaches.

Paradoxically, the presence of vascular risk factors in middle age is associated with the development of AD more strongly than late-life vascular disease. In fact, some research suggests that vascular symptoms later in life may have a protective effect against the development of the disease. The physiopathological mechanisms that may underlie this phenomenon are discussed.

To date, trials that target major cardiovascular risk factors in the prevention of AD remain inconclusive but have become an important focus of international research as described by contributors of this special volume in their overviews. The multifactorial nature of AD and the need to identify the proper time window for intervention when designing possible interventions, and methodological issues that will have to be addressed to achieve an optimal design of new randomized controlled trials, are discussed. Promising avenues for treatment, such as the potential of low-level light therapy to increase the rate of oxygen consumption in the brain and enhance cortical metabolic capacity, and the possibility that some antihypertensive drug classes reduce the risk and progression of AD more than others, are discussed.

Dr. de la Torre notes that the presence of vascular risk factors is not an absolute pathway to dementia, and it may be as important to study how or why individuals who are cognitively normal but have vascular risk are able to avoid dementia. "Reducing Alzheimer's disease prevalence by focusing right now on vascular risk factors to Alzheimer's disease, even with our limited technology, is not a simple or easy task. But the task must begin somewhere and without delay because time is running out for millions of people whose destiny with dementia may start sooner rather than later," he concludes.


'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Controlling depression is associated with improved health for heart-failure patients
2. A new approach for controlling the skyrocketing cost of health care
3. Controlling superconductors with light
4. Study finds people have difficulty controlling multiple chronic conditions
5. Aggressively controlling glucose levels may not reduce kidney failure in Type 2 diabetes
6. Novel drug candidates offer new route to controlling inflammation
7. Sooner Is Better for Controlling Obese Kids Weight: Study
8. US Hispanics at high risk for cardiovascular disease
9. $1.8 million grant supports investigation of psoriasis link to cardiovascular disease
10. Cardiovascular disease community calls for tougher targets to curb global risk
11. OSA increases cardiovascular mortality in the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... TN (PRWEB) , ... June 24, 2016 , ... ... population health management skills and infrastructure. Most providers, however, are unsure how to ... Population Health Ascend to define a path forward tailored to an organization’s ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, InhaleLabs.com ... ingestion of their medication by matching users with high quality water pipes within an ... with no commitment. , Inhale was founded by two brothers, Nick and Mike Hunter, ...
(Date:6/24/2016)... ... , ... Dr. Seema Daulat, a native Texan and University of Texas at ... of July 13, 2016. , Dr. Daulat earned her Doctorate of Medicine (MD) at ... at the Agape Clinic serving Dallas’ underprivileged community. , Following medical school, Dr. Daulat ...
(Date:6/23/2016)... ... June 23, 2016 , ... An article published June 8 on ... head and neck cancer in individuals with unhealthy oral hygiene habits. The article goes ... whether they had gum disease, brushed their teeth on a daily basis, wore dentures ...
(Date:6/23/2016)... ... June 23, 2016 , ... The Mechille Wilson Agency, a Texas-based insurance ... and the surrounding region, is initiating a charity drive to assist a student to ... for a scholarship fund that will be presented to the chosen student to help ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
(Date:6/23/2016)... 2016 Leading BioSciences Inc., a clinical-stage ... resulting from a breakdown of the mucosal barrier, ... Doyle as chief executive officer. Mr. Doyle, ... team and board of directors, previously served as ... will provide continued leadership and strategic direction to ...
Breaking Medicine Technology: