Navigation Links
Controlling vascular disease may be key to reducing prevalence of Alzheimer's disease
Date:11/5/2012

Amsterdam, NL, November 5, 2012 Over the last 15 years, researchers have found a significant association between vascular diseases such as hypertension, atherosclerosis, diabetes type 2, hyperlipidemia, and heart disease and an increased risk of Alzheimer's disease. In a special issue of the Journal of Alzheimer's Disease, leading experts provide a comprehensive overview of the pathological, biochemical, and physiological processes that contribute to Alzheimer's disease risk and ways that may delay or reverse these age-related abnormalities.

"Vascular risk factors to Alzheimer's disease offer the possibility of markedly reducing incident dementia by early identification and appropriate medical management of these likely precursors of cognitive deterioration and dementia," says Guest Editor Jack C. de la Torre, MD, PhD, of the University of Texas, Austin. "Improved understanding coupled with preventive strategies could be a monumental step forward in reducing worldwide prevalence of Alzheimer's disease, which is doubling every 20 years."

The issue explores how vascular disease can affect cerebral blood flow and impair signaling, contributing to Alzheimer's disease (AD). The diagnostics of cardiovascular risk factors in AD are addressed, as are potential therapeutic approaches.

Paradoxically, the presence of vascular risk factors in middle age is associated with the development of AD more strongly than late-life vascular disease. In fact, some research suggests that vascular symptoms later in life may have a protective effect against the development of the disease. The physiopathological mechanisms that may underlie this phenomenon are discussed.

To date, trials that target major cardiovascular risk factors in the prevention of AD remain inconclusive but have become an important focus of international research as described by contributors of this special volume in their overviews. The multifactorial nature of AD and the need to identify the proper time window for intervention when designing possible interventions, and methodological issues that will have to be addressed to achieve an optimal design of new randomized controlled trials, are discussed. Promising avenues for treatment, such as the potential of low-level light therapy to increase the rate of oxygen consumption in the brain and enhance cortical metabolic capacity, and the possibility that some antihypertensive drug classes reduce the risk and progression of AD more than others, are discussed.

Dr. de la Torre notes that the presence of vascular risk factors is not an absolute pathway to dementia, and it may be as important to study how or why individuals who are cognitively normal but have vascular risk are able to avoid dementia. "Reducing Alzheimer's disease prevalence by focusing right now on vascular risk factors to Alzheimer's disease, even with our limited technology, is not a simple or easy task. But the task must begin somewhere and without delay because time is running out for millions of people whose destiny with dementia may start sooner rather than later," he concludes.


'/>"/>

Contact: Esther Mateike
e.mateike@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Controlling depression is associated with improved health for heart-failure patients
2. A new approach for controlling the skyrocketing cost of health care
3. Controlling superconductors with light
4. Study finds people have difficulty controlling multiple chronic conditions
5. Aggressively controlling glucose levels may not reduce kidney failure in Type 2 diabetes
6. Novel drug candidates offer new route to controlling inflammation
7. Sooner Is Better for Controlling Obese Kids Weight: Study
8. US Hispanics at high risk for cardiovascular disease
9. $1.8 million grant supports investigation of psoriasis link to cardiovascular disease
10. Cardiovascular disease community calls for tougher targets to curb global risk
11. OSA increases cardiovascular mortality in the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... 2016 , ... Trinity Health today launched its inaugural Innovation ... at improving care and reducing readmission rates for patients who are dually eligible ... is to drive innovation that transforms our ministry and our industry to be ...
(Date:5/4/2016)... SCOTTSDALE, AZ (PRWEB) , ... May 04, 2016 ... ... 2016 Annual Technology & Business Conference. The conference opened on Tuesday with Frank ... panel discussion on NCPDP’s PDMP Solution provided a deep dive on NCPDP’s model ...
(Date:5/4/2016)... ... 04, 2016 , ... Level 10 Head Over Heels Athletic Arts’ gymnast Alessandra ... of Arizona for the fall of 2019. , After a handful of college ... the GymCats came from her connection with the coaching staff and the excitement surrounding ...
(Date:5/4/2016)... ... May 04, 2016 , ... IsoComforter, Inc., one of ... the innovative newly improved Iso-Hip Wrap. The newly designed hip wrap has ... comfort and enables the patient to enjoy the benefits of cold therapy while ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nike Rugby Camp's success is ... San Diego. Willis, founder of Elite Rugby Camps and current Nike Camp director, has ... year since 2009. , “I’m excited for our eighth summer here in San ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... May 3, 2016 BioNovus Innovations LLC ... for Advancing Medical Innovation (IAMI) today announced a ... diagnostics and medical devices. An agreement ... rights to license, develop and commercialize medical innovations ... "This partnership represents a significant advance in ...
(Date:5/3/2016)... , May 3, 2016  Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to further expand ... Photo - http://photos.prnewswire.com/prnh/20160503/362921 ... ... ... ...
(Date:5/3/2016)... , May 3, 2016 ACME ... Jack Whelan and Delaware County Councilman ... HCI) Nasal Spray in all ACME pharmacies ... Centers for Disease Control and Prevention (CDC), naloxone has saved 26,463 ... police officers in Delaware County were authorized ...
Breaking Medicine Technology: