Navigation Links
Controlling for size may also prevent cancer
Date:9/21/2007

Scientists at Johns Hopkins recently discovered that a chemical chain reaction that controls organ size in animals ranging from insects to humans could mean the difference between normal growth and cancer. The study, published in the Sept. 21 issue of Cell, describes how organs can grow uncontrollably huge and become cancerous when this chain reaction is perturbed.

This chain reaction, a domino-like chain of events we call the Hippo pathway, adds a single chemical group on a protein nicknamed Yap, says lead author Duojia Pan, Ph.D., associate professor of molecular biology and genetics. The good news is that maybe all organ growth can be reduced to this one chemical event on the Yap protein but the better news is that we potentially have a new target for cancer therapy.

Pan and colleagues previously had discovered in fruit flies that too much Yap supercharges growth-inducing genes and causes organs to overgrow.

In the new study designed to see if the same effect occurred in mammals, the research team genetically altered mice to make high levels of Yap protein, but only in liver cells. These animals livers grew to be five times the size of a normal mouse liver and often were dotted with large tumors.

We were totally amazed, says Pan. Five times is just a huge effect. When the researchers next looked at a variety of human cancer cells, they found that 20 percent to 30 percent contained increased levels of Yap. We think it might be the extra Yap in these cells contributing to their cancerous growth, says Pan.

Yap, like most proteins, exists in more than one form, in this case two, one with and one without a chemical phosphate tag attached. Such tags can dramatically alter what proteins do in the body.

When the Hopkins team engineered the cells to stop or slow growth, Yap in those cells has its phosphate attached and moves from the nucleusthe brain center of the cellinto the main body of cells, or cytopl
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Controlling Asthma during Pregnancy
2. Controlling Allergies Before They Start
3. Controlling Asthma
4. Controlling High Blood Can Reduce Eye Problems In Diabetics
5. Herb Found To Be Effective In Controlling Blood Sugar Levels
6. Topical Quinolone effective in controlling eardrum perforations
7. Diuretics More Effective In Controlling High Blood Pressure
8. Stomach Hormone to Aid in Controlling Appetite
9. Solution For Controlling The Raising Health Costs
10. Research Identifies Osteoporosis Controlling Protein
11. Researchers Make a Major Strategic Breakthrough in Controlling the AIDS Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... On May 26, 2015, My Positive Perspective host ... Dwayne Windfall. At the start of the episode, Deierlein asks ... unique characteristics with it, so could you tell people how ... “I was reading the newspaper looking for a job when ... for a person with hustle. I responded to the ad ...
(Date:5/26/2015)... May 26, 2015 Synthetic cannabinoids ... to an article published by International Business ... (dubbed K2, Spice, and black mamba) causes unpredictable ... these synthetic substances make it nearly impossible for ... use of the substance due to the frequency ...
(Date:5/26/2015)... Mr. Larry Westenberg is a Licensed Clinical ... or NLP. Mr. Westenberg is recently also certified ... RRT®. While many people have learned small portions ... specific areas, Mr. Westenberg has been studying the application ... He works with people suffering the effects of ...
(Date:5/26/2015)... 26, 2015 National Prevention Week , ... It is supported by the Substance Abuse and ... public awareness of, and action about, substance abuse as ... and coalitions are encouraged to join in promoting prevention ... related issues, and in building community partnerships. , The ...
(Date:5/26/2015)... TX (PRWEB) May 26, 2015 Texas ... opening of its newest clinic on May 25, 2015 in ... 1919 Rogers Road, Suite 102 in Westover Hills and offers ... 7 P.M. , “We’re thrilled about opening this new ... more of our neighbors in San Antonio and to show ...
Breaking Medicine News(10 mins):Health News:My Positive Perspective Broadcasts Episode with Oceans 6 to Discuss Their Role in Helping the Community 2Health News:Synthetic Cannabinoids Can Cause Psychotic Episodes; Doctors at a Loss for Treatment 2Health News:Synthetic Cannabinoids Can Cause Psychotic Episodes; Doctors at a Loss for Treatment 3Health News:Narconon Arrowhead Takes Part in National Prevention Week 2Health News:Narconon Arrowhead Takes Part in National Prevention Week 3Health News:TexPTS Announces New Clinic in San Antonio 2
... Nielsen Company , a leading global information and media company ... advertising and design competitions, announced today that the first-ever ... at www.CLIOHealthcare.com . The submission deadline is August ... June 30, 2009. , , "We are looking forward to ...
... psychiatrists and psychologists from The Child Study Center at NYU ... parents face today , , Expert advice and tips ... disorders, depression, anxiety, homosexuality and more explored on marathon of Doctor ... 1 SIRIUS XM Radio (Nasdaq: SIRI ) today ...
... pilot prevention program targeting fifth graders and their younger ... on Drug Abuse as part of the National Institutes ... award is for two years. The program aims ... and thereby decrease risky behavior and use of drugs ...
... determined that movie characters who smoke, regardless of whether they ... smoking. The study, published in the July 2009 issue of ... Matters More, Good Guys or Bad Guys?" "Previous studies ... initiation of smoking by adolescents, and we wanted to dig ...
... for Dedication to Improving Animal Health and Well-Being , ... for the third annual Thank Your Vet for a ... The national short-essay contest honors America,s veterinarians for their ... have with our pets. The nationwide essay contest runs ...
... National Alliance on Mental Illness (NAMI) reminds Americans that July ... a time for public education about serious mental illness in ... House of Representatives designated July as Bebe Moore Campbell National ... African American novelist and journalist, who also was a voice ...
Cached Medicine News:Health News:Nielsen Announces First-Ever CLIO Healthcare Awards Now Accepting Entries 2Health News:Nielsen Announces First-Ever CLIO Healthcare Awards Now Accepting Entries 3Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 2Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 3Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 4Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 5Health News:SIRIUS XM's Doctor Radio to Air July 4th Family Special '24 Hours About Our Kids: Why Kids Behave the Way They Do' 6Health News:Both good/bad movie characters who smoke influence teens to do the same 2Health News:Search for America's Best Veterinarian Continues With Third Annual 'Thank Your Vet for a Healthy Pet(R)' Contest 2Health News:NAMI Observes Minority Mental Health Awareness Month 2
(Date:5/26/2015)... 2015  Juniper Pharmaceuticals, Inc. (Nasdaq: JNP ) ... developing therapeutics that address unmet medical needs in ... Elston will present at the Marcum MicroCap ... , 4:00 PM EDTLocation: , The Grand Hyatt, ... www.juniperpharma.com, under  ,Investor, or  click here ...
(Date:5/26/2015)... 26, 2015  PAREXEL International Corporation (NASDAQ: PRXL ... the Goldman Sachs Healthcare Conference in Palos Verdes, CA.  ... Officer, will be making a presentation on PAREXEL and ... June 9, 2015. A live webcast of ... of PAREXEL,s website at www.PAREXEL.com in the ...
(Date:5/26/2015)... 26, 2015  OrthoAccel ® Technologies, Inc., the leader ... growth accelerating in response to continued demand from orthodontists ... available in 2,500 practice locations in the U.S. and ... AcceleDent ® is the only FDA-cleared Class II ... orthodontic treatment by as much as 50 percent.  ...
Breaking Medicine Technology:Juniper Pharmaceuticals to Present at Investor Conference on May 28, 2015 2PAREXEL International To Present At Goldman Sachs Healthcare Conference 2OrthoAccel Technologies Continues Trajectory of Accelerated Growth with Over 2,500 Practice Locations 2OrthoAccel Technologies Continues Trajectory of Accelerated Growth with Over 2,500 Practice Locations 3
... FARMINGDALE, N.Y., Nov. 2, 2011 Misonix, Inc. ... company that designs, manufactures, and markets innovative therapeutic ... cosmetic surgery, neurosurgery, laparoscopic surgery and other surgical ... Ultrasonic Bone Cutting System and the SonaStar® Ultrasonic ...
... 2011 Perrigo Company (Nasdaq: PRGO ; TASE) ... Drug Administration (FDA) a New Drug Application (NDA) for testosterone ... the owner of the Reference Listed Drug of its filing. ... the United States District Court for the District of New ...
Cached Medicine Technology:Misonix Announces its Exhibition at the European Association of Neurosurgical Societies 2Misonix Announces its Exhibition at the European Association of Neurosurgical Societies 3Perrigo Confirms Filing for Testosterone Gel 1.0% and Announcement of Patent Infringement Lawsuit by Abbott 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: