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Control of gene expression: Histone occupancy in your genome
Date:4/30/2012

ust be loosened to make way for RNA polymerases, enzymes that transcribe DNA," explains Garrett. "After that, the DNA must be re-condensed through the reassembly of nucleosomes." That, rather than H3 methylation, is the primary activity impaired when the protein Chd1 is nonfunctional. Finally, the investigators experimentally manipulated cultured human cells to eliminate expression of the human counterpart of Chd1a molecular trick equivalent to analyzing Chd1-mutant yeastand observed impaired mono-ubiquitination of human H2B, just like in yeast.

"These experiments show that the function of Chd1 that we see in single-celled yeast is conserved in humans," says Shilatifard, praising what he calls the awesome power of yeast biochemistry and genetics. "Basically, we are able to use yeast as a test tube to discover what the function of these proteins is in you and me. Given the fact that histone mono-ubiquitination is associated with processes that can lead to the development of human cancer, the molecular information obtained in yeast are indispensable for better understanding the role these factors play during human development and disease pathogenesis," says Shilatifard.


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Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

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