Navigation Links
Continued treatment for lupus may boost survival of those patients with end-stage kidney disease
Date:9/20/2011

September 20, 2011 (BRONX, NY) Researchers at Albert Einstein College of Medicine of Yeshiva University have shown that close supervision by rheumatologists and the use of immunosuppressant drugs improve the survival of lupus patients with end-stage kidney diseasea finding that could reverse long-standing clinical practice. Their study appeared in the September 1 online edition of the Journal of Rheumatology.

At least 1.5 million Americans (more than 90 percent of them women) have lupus (officially known as lupus erythematosus), a chronic autoimmune disease that can damage many organs of the body. Treatment usually involves using immunosuppressive drugs to blunt the immune system's attack on the body. Kidney disease is a common complication of lupus, and up to 30 percent of patients with lupus-related kidney disease ultimately develop end-stage renal failure.

"The lupus disease process was thought to become inactive once kidney failure develops," said lead author Anna Broder, M.D., assistant professor of medicine at Einstein. "As a result, patients generally haven't been encouraged to continue with immunosuppressant medications or to follow up with their rheumatologists after developing end-stage kidney disease. But recent studies have suggested that lupus can indeed remain active after patients start dialysis or receive a kidney transplant."

"Our research shows for the first time that under-supervising and under-treating these lupus patients was associated with an increased risk of death," said Dr. Broder.

The Einstein researchers reviewed the charts of 80 lupus patients with end-stage renal disease who had been started on renal replacement therapy (i.e., either kidney dialysis or kidney transplant). Twenty-two of the patients had been seen frequently in rheumatology clinics (two or more visits per year), while the other 58 patients had been followed infrequently (fewer than two visits per year).

Four years after beginning renal replacement therapy, patients who continued to be treated with immunosuppressive medications were less likely to have died compared with patients who took only low doses of prednisone or no medication. (In fact, patients receiving no medication were 13 times more likely to have died compared with patients treated with a combination of immunosuppressive therapies.) The study also found that lupus patients who visited their rheumatologist at least twice a year after starting dialysis had significantly higher four-year survival rates compared with patients who went for fewer follow-up visits.

"If these findings are confirmed by future studies," said Dr. Broder, "they may significantly change the way lupus patients with end-stage renal failure are managed while on dialysis or after receiving kidney transplants."


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. JPMA Supports CPSC Chairman Tenenbaum's Continued Safety Efforts
2. SEIU ULTCW Commends CA Legislature for Measures to Narrow States Budget Gap While Calling for Continued Courage When Addressing the 2010/2011 State Budget
3. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
4. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
5. Clear rules facilitate continued Web interaction among general practitioners
6. Health IT Adoption Rates Drive Orion Health Continued Global Growth
7. MRI may predict continued decline in patients with mild cognitive impairment
8. Pollution controls used during China Olympics could save lives if continued
9. Measles outbreak underscores need for continued vigilance in health care settings
10. American Cancer Society report finds continued progress in reducing cancer mortality
11. Number of laparoscopic bariatric procedures continued to rise between 2003-2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... Plastic and Reconstructive Surgeon Dr. Kevin Sadati, is pleased to announce a new ... building collagen and elastin in their face, neck, and body through a virtually ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... availability of video chat as a standard feature on its secure clinical communication ... text to voice to video depending on the type and urgency of a ...
(Date:5/23/2017)... Segundo, CA (PRWEB) , ... May 23, 2017 ... ... braces can now receive treatment using the SPEED Systemâ„¢ Orthodontics, with or without ... respected orthodontist in El Segundo, CA, who is skilled in providing ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... Patients who ... to receive relaxing sedation dentistry in Mt. Kisco, NY from Advanced Endodontics of Westchester. ... for a variety of treatments. One or more sedation methods may be recommended based ...
(Date:5/22/2017)... ... May 22, 2017 , ... “Homeostasis: The Journey of ... to live with Bipolar 1. Donald Rodriguez takes readers on a rollercoaster ride that ... the dead of winter and to a dark place where Donald considers suicide. ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 2017 Radiology has become the number one ... also spiraled to the number one ranking as a ... ever before as the most complete and reliable method ... lower back pain an MRI may confirm a suspected ... resulting in entirely different treatment protocols.  In these circumstances, ...
(Date:5/9/2017)... WASHINGTON , May 9, 2017  Demonstrating ... the board of directors for the Pharmaceutical Research ... criteria for membership. Biopharmaceutical companies will now have ... in order to be eligible to join PhRMA. ... criteria, the board is sending a clear message ...
(Date:5/8/2017)... , May 8, 2017 MACRA replaces ... from fee for service reimbursement. Black Book Research crowdsource-surveyed ... 1.       The Market for MIPS Compliance Technology ... of physician practices with 3 or more clinicians seek ... by Q4. "Given the magnitude of the changes, the ...
Breaking Medicine Technology: