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Consuming soy peptide may reduce colon cancer metastasis
Date:7/8/2013

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The scientists plan to repeat the study again using 30 mg/kg of lunasin as soon as they can obtain funding. "One tumor is still too many. We'd like to see no tumors," she said.

The scientists said that consuming the equivalent of 20 to 30 mg/kg of lunasin in soy foods would be daunting in terms of number of servings per day. "But it would certainly be possible if food companies began to offer lunasin-enriched soy milk or yogurt," she said, noting that lunasin-enriched flour is already on the market.

De Mejia said that chronic daily exposure to lunasin could make an even bigger difference in terms of cancer development and metastasis. "These animals were acutely exposed to the peptide for only 28 days, and we still achieved these results."

There is evidence that lunasin accumulates in the body tissues, most notably the livers, of animals that have experienced chronic exposure to this bioactive component of soy. "Consuming soy protein regularly in the diet could be important not only for nutrition but also for cancer prevention," she said.

The researchers also plan to begin a year-long study that would model lifetime exposure to lunasin in transgenic mice programmed to develop colon cancer in contrast to a group that did not receive any lunasin, she said.

Human studies are needed to validate the pre-clinical studies, de Mejia added.


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Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

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