Navigation Links
Consuming soy peptide may reduce colon cancer metastasis
Date:7/8/2013

URBANA, Ill. After a recent University of Illinois study showed that injection of the soy peptide lunasin dramatically reduced colon cancer metastasis in mice, the researchers were eager to see how making lunasin part of the animals' daily diet would affect the spread of the disease.

"In this new study, we find that giving lunasin orally at 20 mg/kg of body weight reduced the number of metastatic tumors by 94 percentwe went from 18 tumors to only one. And that was done using lunasin alone; no other type of therapy was used," said Elvira de Mejia, a U of I professor of food chemistry and food toxicology.

In the first study, injections of lunasin were used in concert with the chemotherapy drug oxaliplatin, yielding impressive results: a sixfold reduction in metastatic tumors to the liver.

"We learned in that study that lunasin can penetrate the cancer cell, cause cell death, and interact with at least one type of receptor in a cell that is ready to metastasize," said Vermont Dia, a postdoctoral associate in the de Mejia laboratory.

That led the scientists to do this study in which they experimented with oral doses of the peptide. "After all, soy is a food, and we wanted the animals to consume it as a food. Because this lunasin would be digested, we needed to figure out how much should be fed to achieve the desired concentration in the bloodstream," de Mejia said.

Using mice that had been injected with human colon cancer cells, the scientists began by feeding the animals 8 mg/kg of lunasin daily, which reduced the number of new tumors in the liver by 55 percent. They increased the dose five times, at last achieving a 94 percent reduction in tumors at 20 mg/kg of lunasin.

"We were very impressed by the reduction, but the results were short of statistical significance from the control group. More animals are needed to strengthen the power of the analysis. It's a small study but very promising," de Mejia said.

The scientists plan to repeat the study again using 30 mg/kg of lunasin as soon as they can obtain funding. "One tumor is still too many. We'd like to see no tumors," she said.

The scientists said that consuming the equivalent of 20 to 30 mg/kg of lunasin in soy foods would be daunting in terms of number of servings per day. "But it would certainly be possible if food companies began to offer lunasin-enriched soy milk or yogurt," she said, noting that lunasin-enriched flour is already on the market.

De Mejia said that chronic daily exposure to lunasin could make an even bigger difference in terms of cancer development and metastasis. "These animals were acutely exposed to the peptide for only 28 days, and we still achieved these results."

There is evidence that lunasin accumulates in the body tissues, most notably the livers, of animals that have experienced chronic exposure to this bioactive component of soy. "Consuming soy protein regularly in the diet could be important not only for nutrition but also for cancer prevention," she said.

The researchers also plan to begin a year-long study that would model lifetime exposure to lunasin in transgenic mice programmed to develop colon cancer in contrast to a group that did not receive any lunasin, she said.

Human studies are needed to validate the pre-clinical studies, de Mejia added.


'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related medicine news :

1. Americans Already Consuming the Right Amount of Salt
2. Sugar Addict Claims Americans Consuming 150 lbs of Sugar Yearly
3. U.S. Kids Consuming Fewer Calories, Report Finds
4. Consuming coffee linked to lower risk of detrimental liver disease, Mayo Clinic finds
5. Combination peptide therapies might offer more effective, less toxic cancer treatment
6. Synthetic corkscrew peptide kills antibiotic-resistant Gram-negative bacteria
7. Is this peptide a key to happiness?
8. Global Peptide Therapeutics Market - New Market Research Report Published by Transparency Market Research
9. Collagen is a Key Anti-Aging Ingredient and is Featured in the New Collagen Peptide Serum at Sublime Beauty®; Introductory Offer on Now
10. Last Chance for the Sublime Beauty® Serums at 30-Percent Off; Quality Anti-Aging Products Include Retinol Serum, Collagen Peptide Serum and Luxurious Facial Oil
11. Huntingtons Disease Linked to Reduced Cancer Risk in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Lafayette, California (PRWEB) , ... ... ... a pioneer in the patient payment industry today announced its strategic partnership ... and health system workflows. , The two companies’ proven, proprietary technology combine ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
Breaking Medicine Technology: